A scalable and robust variance components method reveals insights into the architecture of gene-environment interactions underlying complex traits.
Pazokitoroudi A, Dahl A, Zaitlen N, Rosset S, Sankararaman S.
bioRxiv. 2023 Dec 13. PMID: 38168200
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Ali Pazokitoroudi
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Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries.
An U, Pazokitoroudi A, Alvarez M, Huang L, Bacanu S, Schork AJ, Kendler K, Pajukanta P, Flint J, Zaitlen N, Cai N, Dahl A, Sankararaman S.
Nat Genet. 2023 Dec. 55(12):2269-2276. PMID: 37985819
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic epistasis.
Fu B, Pazokitoroudi A, Xue A, Anand A, Anand P, Zaitlen N, Sankararaman S.
bioRxiv. 2023 Sep 12. PMID: 37745394
Fast kernel-based association testing of non-linear genetic effects for biobank-scale data.
Fu B, Pazokitoroudi A, Sudarshan M, Liu Z, Subramanian L, Sankararaman S.
Nat Commun. 2023 08 15. 14(1):4936. PMID: 37582955
The lingering effects of Neanderthal introgression on human complex traits.
Wei X, Robles CR, Pazokitoroudi A, Ganna A, Gusev A, Durvasula A, Gazal S, Loh PR, Reich D, Sankararaman S.
Elife. 2023 03 20. 12. PMID: 36939312
Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions.
Findley AS, Monziani A, Richards AL, Rhodes K, Ward MC, Kalita CA, Alazizi A, Pazokitoroudi A, Sankararaman S, Wen X, Lanfear DE, Pique-Regi R, Gilad Y, Luca F.
Elife. 2021 05 14. 10. PMID: 33988505
Quantifying the contribution of dominance deviation effects to complex trait variation in biobank-scale data.
Pazokitoroudi A, Chiu AM, Burch KS, Pasaniuc B, Sankararaman S.
Am J Hum Genet. 2021 05 06. 108(5):799-808. PMID: 33811807
Efficient variance components analysis across millions of genomes.
Pazokitoroudi A, Wu Y, Burch KS, Hou K, Zhou A, Pasaniuc B, Sankararaman S.
Nat Commun. 2020 08 11. 11(1):4020. PMID: 32782262