Longitudinal Analysis of Contrasts in Gene Expression Data.
Hahn G, Novak T, Crawford JC, Randolph AG, Lange C.
Genes (Basel). 2023 05 24. 14(6). PMID: 37372314
Assistant Professor of Medicine
Medicine-Brigham and Women's Hospital
Harvard Medical School
Research
Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.
Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.
Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.
Education
Ph.D., 2000, University of Reading, United Kingdom
Hahn G, Novak T, Crawford JC, Randolph AG, Lange C.
Genes (Basel). 2023 05 24. 14(6). PMID: 37372314
Hayden LP, Hobbs BD, Busch R, Cho MH, Liu M, Lopes-Ramos CM, Lomas DA, Bakke P, Gulsvik A, Silverman EK, Crapo JD, Beaty TH, Laird NM, Lange C, DeMeo DL.
Respir Res. 2023 Feb 01. 24(1):38. PMID: 36726148
Hecker J, Chun S, Samiei A, Liu C, Laurie C, Kachroo P, Lutz SM, Lee S, Smith AV, Lasky-Su J, Cho MH, Sharma S, Soto Quirós ME, Avila L, Celedón JC, Raby B, Zhou X, Silverman EK, DeMeo DL, Lange C, Weiss ST.
Hum Mol Genet. 2023 01 27. 32(4):696-707. PMID: 36255742
Lee S, Hahn G, Hecker J, Lutz SM, Mullin K, Hide W, Bertram L, DeMeo DL, Tanzi RE, Lange C, Prokopenko D.
Brief Bioinform. 2023 01 19. 24(1). PMID: 36585781
Lee S, Prokopenko D, Kelly RS, Lutz S, Ann Lasky-Su J, Cho MH, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J, DeMeo DL.
Eur Respir J. 2023 01. 61(1). PMID: 35953101
Hahn G, Lee S, Prokopenko D, Abraham J, Novak T, Hecker J, Cho M, Khurana S, Baden LR, Randolph AG, Weiss ST, Lange C.
BMC Bioinformatics. 2022 Dec 19. 23(1):547. PMID: 36536276
Lee S, Zhang Y, Newhams M, Novak T, Thomas PG, Mourani PM, Hall MW, Loftis LL, Cvijanovich NZ, Tarquinio KM, Schwarz AJ, Weiss SL, Thomas NJ, Markovitz B, Cullimore ML, Sanders RC, Zinter MS, Sullivan JE, Halasa NB, Bembea MM, Giuliano JS, Typpo KV, Nofziger RA, Shein SL, Kong M, Coates BM, Weiss ST, Lange C, Su HC, Randolph AG.
J Infect Dis. 2022 11 28. 226(11):2030-2036. PMID: 35986912
Hecker J, Prokopenko D, Moll M, Lee S, Kim W, Qiao D, Voorhies K, Kim W, Vansteelandt S, Hobbs BD, Cho MH, Silverman EK, Lutz SM, DeMeo DL, Weiss ST, Lange C.
PLoS Genet. 2022 11. 18(11):e1010464. PMID: 36383614
Kim W, Hecker J, Barr RG, Boerwinkle E, Cade B, Correa A, Dupuis J, Gharib SA, Lange L, London SJ, Morrison AC, O'Connor GT, Oelsner EC, Psaty BM, Vasan RS, Redline S, Rich SS, Rotter JI, Yu B, Lange C, Manichaikul A, Zhou JJ, Sofer T, Silverman EK, Qiao D, Cho MH.
Hum Mol Genet. 2022 11 10. 31(22):3873-3885. PMID: 35766891
Ge T, Irvin MR, Patki A, Srinivasasainagendra V, Lin YF, Tiwari HK, Armstrong ND, Benoit B, Chen CY, Choi KW, Cimino JJ, Davis BH, Dikilitas O, Etheridge B, Feng YA, Gainer V, Huang H, Jarvik GP, Kachulis C, Kenny EE, Khan A, Kiryluk K, Kottyan L, Kullo IJ, Lange C, Lennon N, Leong A, Malolepsza E, Miles AD, Murphy S, Namjou B, Narayan R, O'Connor MJ, Pacheco JA, Perez E, Rasmussen-Torvik LJ, Rosenthal EA, Schaid D, Stamou M, Udler MS, Wei WQ, Weiss ST, Ng MCY, Smoller JW, Lebo MS, Meigs JB, Limdi NA, Karlson EW.
Genome Med. 2022 06 29. 14(1):70. PMID: 35765100
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