A novel locus for exertional dyspnoea in childhood asthma.
Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J.
Eur Respir J. 2021 Feb. 57(2). PMID: 32855217
Assistant Professor of Medicine
Medicine
Brigham and Women's Hospital
Research
Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.
Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.
Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.
Education
Ph.D., 2000, University of Reading, United Kingdom
Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J.
Eur Respir J. 2021 Feb. 57(2). PMID: 32855217
Hahn G, Lee S, Weiss ST, Lange C.
Genet Epidemiol. 2021 Jan 08. PMID: 33415739
Hecker J, William Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C.
Bioinformatics. 2020 Dec 26. PMID: 33367522
Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J.
Pediatr Allergy Immunol. 2021 Feb. 32(2):373-376. PMID: 32946604
Hahn G, Lutz SM, Hecker J, Prokopenko D, Cho MH, Silverman EK, Weiss ST, Lange C.
Genet Epidemiol. 2021 Feb. 45(1):82-98. PMID: 32929743
Hahn G, Lee S, Weiss ST, Lange C.
bioRxiv. 2020 Jun 30. PMID: 32637949
Hahn G, Cho MH, Weiss ST, Silverman EK, Lange C.
bioRxiv. 2020 Jun 30. PMID: 32637951
Prokopenko D, Hecker J, Kirchner R, Chapman BA, Hoffman O, Mullin K, Hide W, Bertram L, Laird N, DeMeo DL, Lange C, Tanzi RE.
Sci Rep. 2020 03 19. 10(1):5029. PMID: 32193444
Lutz SM, Sordillo JE, Hokanson JE, Chen Wu A, Lange C.
Genet Epidemiol. 2020 06. 44(4):400-403. PMID: 32166765
Hecker J, Ruczinski I, Cho MH, Silverman EK, Coull B, Lange C.
Genet Epidemiol. 2020 03. 44(2):139-147. PMID: 31713269