Assistant Professor of Medicine
Medicine
Brigham and Women's Hospital
Research
Christoph's research interests are at the intersection of biostatistical methodology, numerical analysis, and computer science. Formally trained in all 3 areas, Christoph headed the analysis of the first genome-wide association study for complex diseases, the longitudinal analysis of BMI in the Framingham Heart Study. To address the challenges of this first wave of "big data" in genetics, Christoph's group developed statistical methodology to maximize power in such studies that minimize the effects of the multiple testing problem in GWAS and developed massively parallel software implementations for the analysis that also efficiently scale with the study size (PBAT software package). Christoph's group then successfully commercialized
the package in collaboration with GoldenHelix.
Currently, Christoph's group focuses on the statistical and computational challenges posed by whole-genome sequencing studies, e.g. powerful analysis methodology, clustering approaches of the genome, approaches to permutation testing, storage algorithm, etc.
Christoph is also involved in collaborative research in Asthma Genetics, COPD Genetics, and Alzheimer's Genetics.
Education
Ph.D., 2000, University of Reading, United Kingdom
Hahn G, Wu CM, Lee S, Lutz SM, Khurana S, Baden LR, Haneuse S, Qiao D, Hecker J, DeMeo DL, Tanzi RE, Choudhary MC, Etemad B, Mohammadi A, Esmaeilzadeh E, Cho MH, Li JZ, Randolph AG, Laird NM, Weiss ST, Silverman EK, Ribbeck K, Lange C.
Genet Epidemiol. 2021 10. 45(7):685-693. PMID: 34159627
Lutz SM, Wu AC, Hokanson JE, Vansteelandt S, Lange C.
Genet Epidemiol. 2021 Jul. 45(5):445-454. PMID: 34008876
Lee S, Lasky-Su J, Won S, Laurie C, Celedón JC, Lange C, Weiss S, Hecker J.
Thorax. 2021 Apr 22. PMID: 33888571
Lee S, Lasky-Su JA, Lange C, Kim W, Kumar PL, McDonald MN, Vaz Fragoso CA, Laurie C, Raby BA, Celedón JC, Cho MH, Won S, Weiss ST, Hecker J.
Eur Respir J. 2021 02. 57(2). PMID: 32855217
Hahn G, Lee S, Weiss ST, Lange C.
Genet Epidemiol. 2021 04. 45(3):316-323. PMID: 33415739
Hecker J, William Townes F, Kachroo P, Laurie C, Lasky-Su J, Ziniti J, Cho MH, Weiss ST, Laird NM, Lange C.
Bioinformatics. 2020 Dec 26. PMID: 33367522
Hahn G, Lee S, Weiss ST, Lange C.
bioRxiv. 2020 Nov 20. PMID: 32637949
Lee S, Lasky-Su J, Kim W, Won S, Laurie C, Celedón JC, Lange C, Weiss ST, Hecker J.
Pediatr Allergy Immunol. 2021 02. 32(2):373-376. PMID: 32946604
Hahn G, Lutz SM, Hecker J, Prokopenko D, Cho MH, Silverman EK, Weiss ST, Lange C.
Genet Epidemiol. 2021 02. 45(1):82-98. PMID: 32929743
Hahn G, Cho MH, Weiss ST, Silverman EK, Lange C.
bioRxiv. 2020 Jun 30. PMID: 32637951
Compares mutations to mortality in order to identify variants that should be monitored and contained For immediate release: Wednesday, June 23, 2021 Boston, MA – Using genome-wide association studies (GWAS) methodology to analyze whole-genome sequencing data of SARS-CoV-2 mutations…
For immediate release: Thursday, April 3, 2008 Boston, MA - A team of researchers from Harvard School of Public Health (HSPH), Brigham and Women's Hospital (BWH), and elsewhere have described a possible reason why some studies have been…