ATM phosphorylates the FATC domain of DNA-PK cs at threonine 4102 to promote non-homologous end joining.
Lu H, Zhang Q, Laverty DJ, Puncheon AC, Williams GJ, Nagel ZD, Chen BP, Davis AJ.
bioRxiv. 2023 Feb 02. PMID: 36778257
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Daniel J Laverty
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Correction to "Selective Inhibition of DNA Polymerase ß by a Covalent Inhibitor".
Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM.
J Am Chem Soc. 2022 Feb 16. 144(6):2825. PMID: 35113563
Kinase Inhibitor Library Screening Identifies the Cancer Therapeutic Sorafenib and Structurally Similar Compounds as Strong Inhibitors of the Fungal Pathogen Histoplasma capsulatum.
Berkes C, Franco J, Lawson M, Brann K, Mermelstein J, Laverty D, Connors A.
Antibiotics (Basel). 2021 Oct 08. 10(10). PMID: 34680804
Selective Inhibition of DNA Polymerase ß by a Covalent Inhibitor.
Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM.
J Am Chem Soc. 2021 06 02. 143(21):8099-8107. PMID: 34014094
An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation.
Nguyen MT, Moiani D, Ahmed Z, Arvai AS, Namjoshi S, Shin DS, Fedorov Y, Selvik EJ, Jones DE, Pink J, Yan Y, Laverty DJ, Nagel ZD, Tainer JA, Gerson SL.
Prog Biophys Mol Biol. 2021 08. 163:143-159. PMID: 33675849
Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.
Alvarado-Cruz I, Mahmoud M, Khan M, Zhao S, Oeck S, Meas R, Clairmont K, Quintana V, Zhu Y, Porciuncula A, Wyatt H, Ma S, Shyr Y, Kong Y, LoRusso PM, Laverty D, Nagel ZD, Schalper KA, Krauthammer M, Sweasy JB.
Biochem Pharmacol. 2021 02. 184:114359. PMID: 33285109
Expanded Substrate Scope of DNA Polymerase ? and DNA Polymerase ß: Lyase Activity on 5'-Overhangs and Clustered Lesions.
Laverty DJ, Greenberg MM.
Biochemistry. 2018 10 23. 57(42):6119-6127. PMID: 30299084
Mechanistic Insight through Irreversible Inhibition: DNA Polymerase ? Uses a Common Active Site for Polymerase and Lyase Activities.
Laverty DJ, Mortimer IP, Greenberg MM.
J Am Chem Soc. 2018 07 25. 140(29):9034-9037. PMID: 29998737
In Vitro Bypass of Thymidine Glycol by DNA Polymerase ? Forms Sequence-Dependent Frameshift Mutations.
Laverty DJ, Greenberg MM.
Biochemistry. 2017 12 26. 56(51):6726-6733. PMID: 29243925
The A-Rule and Deletion Formation During Abasic and Oxidized Abasic Site Bypass by DNA Polymerase ?.
Laverty DJ, Averill AM, Doublié S, Greenberg MM.
ACS Chem Biol. 2017 06 16. 12(6):1584-1592. PMID: 28459528