Daniel J Laverty

ATM inhibition exploits checkpoint defects and ATM-dependent double strand break repair in TP53-mutant glioblastoma.

Laverty DJ, Gupta SK, Bradshaw GA, Hunter AS, Carlson BL, Calmo NM, Chen J, Tian S, Sarkaria JN, Nagel ZD.

Nat Commun. 2024 Jun 21. 15(1):5294. PMID: 38906885

CDK-independent role of D-type cyclins in regulating DNA mismatch repair.

Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M.

Mol Cell. 2024 Apr 04. 84(7):1224-1242.e13. PMID: 38458201

Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization.

Chen J, Laverty DJ, Talele S, Bale A, Carlson BL, Porath KA, Bakken KK, Burgenske DM, Decker PA, Vaubel RA, Eckel-Passow JE, Bhargava R, Lou Z, Hamerlik P, Harley B, Elmquist WF, Nagel ZD, Gupta SK, Sarkaria JN.

Sci Transl Med. 2024 Feb 14. 16(734):eadj5962. PMID: 38354228

D-type cyclins regulate DNA mismatch repair in the G1 and S phases of the cell cycle, maintaining genome stability.

Rona G, Miwatani-Minter B, Zhang Q, Goldberg HV, Kerzhnerman MA, Howard JB, Simoneschi D, Lane E, Hobbs JW, Sassani E, Wang AA, Keegan S, Laverty DJ, Piett CG, Pongor LS, Xu ML, Andrade J, Thomas A, Sicinski P, Askenazi M, Ueberheide B, Fenyö D, Nagel ZD, Pagano M.

bioRxiv. 2024 Jan 13. PMID: 38260436

REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors.

Vassel FM, Laverty DJ, Bian K, Piett CG, Hemann MT, Walker GC, Nagel ZD.

Int J Mol Sci. 2023 Oct 31. 24(21). PMID: 37958783

ATM phosphorylates the FATC domain of DNA-PKcs at threonine 4102 to promote non-homologous end joining.

Lu H, Zhang Q, Laverty DJ, Puncheon AC, Augustine MM, Williams GJ, Nagel ZD, Chen BPC, Davis AJ.

Nucleic Acids Res. 2023 07 21. 51(13):6770-6783. PMID: 37309889

ATM phosphorylates the FATC domain of DNA-PK cs at threonine 4102 to promote non-homologous end joining.

Lu H, Zhang Q, Laverty DJ, Puncheon AC, Williams GJ, Nagel ZD, Chen BP, Davis AJ.

bioRxiv. 2023 Feb 02. PMID: 36778257

Correction to "Selective Inhibition of DNA Polymerase ß by a Covalent Inhibitor".

Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM.

J Am Chem Soc. 2022 Feb 16. 144(6):2825. PMID: 35113563

Kinase Inhibitor Library Screening Identifies the Cancer Therapeutic Sorafenib and Structurally Similar Compounds as Strong Inhibitors of the Fungal Pathogen Histoplasma capsulatum.

Berkes C, Franco J, Lawson M, Brann K, Mermelstein J, Laverty D, Connors A.

Antibiotics (Basel). 2021 Oct 08. 10(10). PMID: 34680804

Selective Inhibition of DNA Polymerase ß by a Covalent Inhibitor.

Yuhas SC, Laverty DJ, Lee H, Majumdar A, Greenberg MM.

J Am Chem Soc. 2021 06 02. 143(21):8099-8107. PMID: 34014094