Associations of Dietary Sugar Types with Coronary Heart Disease Risk: A Prospective Cohort Study.
Dennis KK, Wang F, Li Y, Manson JE, Rimm EB, Hu FB, Willett WC, Stampfer MJ, Wang DD.
Am J Clin Nutr. 2023 Aug 31. PMID: 37659725
Assistant Professor of Medicine
Medicine-Brigham and Women's Hospital
Harvard Medical School
My research is situated where nutrition, the human microbiome, and chronic disease epidemiology intersect. My research program has several key objectives: understanding the interindividual variability in response to diet, discovering novel biomarkers predictive of aging-related chronic diseases, and informing personalized dietary approaches for more effective prevention of cardiometabolic disease and Alzheimer's dementia. To achieve these aims, our ongoing research initiatives integrate epidemiological methods, bioinformatic tools, and emerging 'omics technologies. Furthermore, we employ a multi'omics approach, encompassing metagenomics, metatranscriptomics, and metabolomics, to decode the functional role of the microbial community in human health.
I currently serve as the PI of an R01 project (R01AG077489) that investigates the interactions between healthy dietary patterns and the gut microbiome to enhance the dietary prevention of Alzheimer's dementia. In this NIA-funded project, we have identified dysbiosis-related markers, such as Veillonella spp. and the opportunistic pathogen Erysipelatoclostridium ramosum, as indicators of cognitive decline in the Nurses' Health Study II (NHSII). I am also the PI of another R01 project (R01NR019992), which aims to identify gut microbial features, fecal and plasma metabolites, and their role in explaining interindividual variations in metabolic risk changes following dietary interventions in two randomized controlled dietary trials. This project also investigates the combined effects of Mediterranean diet interventions and autologous fecal microbiota transplantation. Furthermore, I serve as the PI of an R00 project (R00DK119412) that examines the associations between the Mediterranean diet, dietary polyphenols, the gut microbiome, body adiposity, and biomarkers of type 2 diabetes in the DIRECT-PLUS Trial, the Study of Latinos, NHSII, and the Health Professionals Follow-Up Study. In this R00 project, we found, for the first time, that the associations of a Mediterranean dietary pattern with blood biomarkers and prevalence of type 2 diabetes varied in individuals with different gut microbial profiles in white and Hispanic populations.
ScD, 05/2016, Nutrition and Epidemiology
Harvard T.H. Chan School of Public Health, Boston, MA
MD, 06/2004, Preventive Medicine
Anhui Medical University, Hefei, China
MS, 06/2007, Nutrition
National Institute for Nutrition and Health, Beijing, China
Postdoctoral Fellowship, 08/2018, Metabolomics
Harvard T.H. Chan School of Public Health, Boston, MA
Postdoctoral Fellowship, 08/2020, Human Microbiome and Computational Biology
Harvard T.H. Chan School of Public Health, Boston, MA
Dennis KK, Wang F, Li Y, Manson JE, Rimm EB, Hu FB, Willett WC, Stampfer MJ, Wang DD.
Am J Clin Nutr. 2023 Aug 31. PMID: 37659725
Gu X, Wang DD, Sampson L, Barnett JB, Rimm EB, Stampfer MJ, Djousse L, Rosner B, Willett WC.
Am J Epidemiol. 2023 Aug 08. PMID: 37552965
Wang K, Mehta RS, Ma W, Nguyen LH, Wang DD, Ghazi AR, Yan Y, Al-Shaar L, Wang Y, Hang D, Fu BC, Ogino S, Rimm EB, Hu FB, Carmody RN, Garrett WS, Sun Q, Chan AT, Huttenhower C, Song M.
Microbiome. 2023 05 30. 11(1):121. PMID: 37254152
Shan Z, Wang F, Li Y, Baden MY, Bhupathiraju SN, Wang DD, Sun Q, Rexrode KM, Rimm EB, Qi L, Tabung FK, Giovannucci EL, Willett WC, Manson JE, Qi Q, Hu FB.
JAMA Intern Med. 2023 02 01. 183(2):142-153. PMID: 36622660
Musicus AA, Wang DD, Janiszewski M, Eshel G, Blondin SA, Willett W, Stampfer MJ.
Lancet Planet Health. 2022 11. 6(11):e892-e900. PMID: 36370727
Gu X, Wang DD, Fung TT, Mozaffarian D, Djoussé L, Rosner B, Sacks FM, Willett WC.
Am J Clin Nutr. 2022 08 04. 116(2):378-385. PMID: 35511594
Li Y, Wang F, Li J, Ivey KL, Wilkinson JE, Wang DD, Li R, Liu G, Eliassen HA, Chan AT, Clish CB, Huttenhower C, Hu FB, Sun Q, Rimm EB.
BMC Microbiol. 2022 03 29. 22(1):82. PMID: 35350985
Wang DD, Li Y, Nguyen XT, Song RJ, Ho YL, Hu FB, Willett WC, Wilson PWF, Cho K, Gaziano JM, Djoussé L.
Public Health Nutr. 2022 Mar 21. 1-38. PMID: 35307047
Rinott E, Meir AY, Tsaban G, Zelicha H, Kaplan A, Knights D, Tuohy K, Scholz MU, Koren O, Stampfer MJ, Wang DD, Shai I, Youngster I.
Genome Med. 2022 03 10. 14(1):29. PMID: 35264213
Wang DD, Li Y, Nguyen XT, Song RJ, Ho YL, Hu FB, Willett WC, Wilson PWF, Cho K, Gaziano JM, Djoussé L.
Nutrients. 2022 Mar 07. 14(5). PMID: 35268096