Our laboratory seeks to discover physical laws governing the abilities of the cytoskeleton to deform, contract, and remodel. These basic mechanical processes underlie a range of higher level phenomena in health and disease including many aspects of cancer, cardiovascular disease, malaria, and morphogenesis, but our major research emphasis is the role of these processes in airway narrowing in asthma. Trainees with backgrounds in engineering sciences, cell biology, or physics of soft condensed matter learn how to work side-by-side to pose new questions, invent new nanotechnologies, apply these technologies in novel experimental investigations, and analyze resulting data in terms of evolving mechanistic understanding of the physical properties of the living cell.
BSME, 1968
Tufts University, Medford, Massachusetts
PhD, 1973
Massachusetts Institute of Technology, Cambridge, Massachusetts
He S, Lei P, Kang W, Cheung P, Xu T, Mana M, Park CY, Wang H, Imada S, Russell JO, Wang J, Wang R, Zhou Z, Chetal K, Stas E, Mohad V, Bruun-Rasmussen P, Sadreyev RI, Hodin RA, Zhang Y, Breault DT, Camargo FD, Yilmaz ÖH, Fredberg JJ, Saeidi N.
Gastroenterology. 2023 Mar 03. PMID: 36871599
Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q.
Nat Commun. 2023 01 04. 14(1):47. PMID: 36599824
Vahabikashi A, Sivagurunathan S, Nicdao FAS, Han YL, Park CY, Kittisopikul M, Wong X, Tran JR, Gundersen GG, Reddy KL, Luxton GWG, Guo M, Fredberg JJ, Zheng Y, Adam SA, Goldman RD.
Proc Natl Acad Sci U S A. 2022 04 26. 119(17):e2121816119. PMID: 35439057
Wu H, Shen Y, Sivagurunathan S, Weber MS, Adam SA, Shin JH, Fredberg JJ, Medalia O, Goldman R, Weitz DA.
Proc Natl Acad Sci U S A. 2022 03 08. 119(10):e2115217119. PMID: 35235449
Mwase C, Phung TN, O'Sullivan MJ, Mitchel JA, De Marzio M, Kiliç A, Weiss ST, Fredberg JJ, Park JA.
Cells. 2022 01 13. 11(2). PMID: 35053372
Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ.
iScience. 2021 Nov 19. 24(11):103252. PMID: 34755092
Mohammed D, Park CY, Fredberg JJ, Weitz DA.
Sci Rep. 2021 08 11. 11(1):16279. PMID: 34381087
Atia L, Fredberg JJ, Gov NS, Pegoraro AF.
Cells Dev. 2021 Dec. 168:203727. PMID: 34363993
De Marzio M, Kiliç A, Maiorino E, Mitchel JA, Mwase C, O'Sullivan MJ, McGill M, Chase R, Fredberg JJ, Park JA, Glass K, Weiss ST.
Sci Adv. 2021 07. 7(30). PMID: 34301595
Finding links physics of granular systems to biology of asthma and embryonic development For immediate release: April 2, 2018 Boston, MA – Cells comprising a tissue can pack into disorderly geometries much as do grains of sand in…
December 13, 2016 – Christalyn Rhodes has been named a 2017 Harvard University Horizons Scholar. Rhodes is a Ph.D. student in Biological Sciences in Public Health at Harvard T.H. Chan School of Public Health, and her thesis research focuses…
Biologists and physicists are becoming increasingly convinced that clusters of tumor cells that can move through the body like a phalanx may be responsible for some of the deadliest metastatic cancers. An August 16, 2016 article in Quanta…
Finding offers insight into mechanisms of asthma, other diseases August 11, 2015 -- An unexpected new discovery—that, in people with asthma, the cells that line the airways in the lungs are unusually shaped and “scramble around like there’s…
For immediate release: Sunday, June 23, 2013 Boston, MA – A new discovery about how cells move inside the body may provide scientists with crucial information about disease mechanisms such as the spread of cancer or the constriction of…
