Epithelial layer fluidization by curvature-induced unjamming.
Marzio M, Das A, Fredberg JJ, Bi D.
ArXiv. 2023 May 22. PMID: 37292460
Primary Faculty
Jeffrey J. Fredberg
Overview
Our laboratory seeks to discover physical laws governing the abilities of the cytoskeleton to deform, contract, and remodel. These basic mechanical processes underlie a range of higher level phenomena in health and disease including many aspects of cancer, cardiovascular disease, malaria, and morphogenesis, but our major research emphasis is the role of these processes in airway narrowing in asthma. Trainees with backgrounds in engineering sciences, cell biology, or physics of soft condensed matter learn how to work side-by-side to pose new questions, invent new nanotechnologies, apply these technologies in novel experimental investigations, and analyze resulting data in terms of evolving mechanistic understanding of the physical properties of the living cell.
BSME, 1968
Tufts University, Medford, Massachusetts
PhD, 1973
Massachusetts Institute of Technology, Cambridge, Massachusetts
Bibliography
Stiffness Restricts the Stemness of the Intestinal Stem Cells and Skews Their Differentiation Toward Goblet Cells.
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Gastroenterology. 2023 06. 164(7):1137-1151.e15. PMID: 36871599
Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness.
Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q.
Nat Commun. 2023 01 04. 14(1):47. PMID: 36599824
Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics.
Vahabikashi A, Sivagurunathan S, Nicdao FAS, Han YL, Park CY, Kittisopikul M, Wong X, Tran JR, Gundersen GG, Reddy KL, Luxton GWG, Guo M, Fredberg JJ, Zheng Y, Adam SA, Goldman RD.
Proc Natl Acad Sci U S A. 2022 04 26. 119(17):e2121816119. PMID: 35439057
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex.
Wu H, Shen Y, Sivagurunathan S, Weber MS, Adam SA, Shin JH, Fredberg JJ, Medalia O, Goldman R, Weitz DA.
Proc Natl Acad Sci U S A. 2022 03 08. 119(10):e2115217119. PMID: 35235449
Mechanical Compression of Human Airway Epithelial Cells Induces Release of Extracellular Vesicles Containing Tenascin C.
Mwase C, Phung TN, O'Sullivan MJ, Mitchel JA, De Marzio M, Kiliç A, Weiss ST, Fredberg JJ, Park JA.
Cells. 2022 01 13. 11(2). PMID: 35053372
A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation.
Kang W, Ferruzzi J, Spatarelu CP, Han YL, Sharma Y, Koehler SA, Mitchel JA, Khan A, Butler JP, Roblyer D, Zaman MH, Park JA, Guo M, Chen Z, Pegoraro AF, Fredberg JJ.
iScience. 2021 Nov 19. 24(11):103252. PMID: 34755092
Tumorigenic mesenchymal clusters are less sensitive to moderate osmotic stresses due to low amounts of junctional E-cadherin.
Mohammed D, Park CY, Fredberg JJ, Weitz DA.
Sci Rep. 2021 08 11. 11(1):16279. PMID: 34381087
Are cell jamming and unjamming essential in tissue development?
Atia L, Fredberg JJ, Gov NS, Pegoraro AF.
Cells Dev. 2021 Dec. 168:203727. PMID: 34363993
News
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Unexpected discovery of the ways cells move could boost understanding of complex diseases
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