Research Fellows

Jie Hu

Postdoctoral Research Fellow

Epidemiology

jhu13@bwh.harvard.edu

Other Positions

Research Fellow in Anaesthesia

Anaesthesia-Massachusetts General Hospital

Harvard Medical School


Overview

I am a Research Fellow in the Saxena Lab in the Center for Genomic Medicine and Department of Anaesthesia at Massachusetts General Hospital and Harvard Medical School, and the Liang Lab in the Department of Epidemiology at Harvard T.H. Chan School of Public Health. I am an epidemiologist with rich research experience in maternal and child health, women’s health, and environmental health. My long-term career goal is to become an independent researcher in the area of women’s and children’s health and cardiometabolic disease epidemiology, focusing on identifying novel risk factors, investigating the intergenerational link in disease susceptibility and the influencing factors, and examining health disparities and the underlying mechanisms to promote personalized treatment and prevention.

I am interested the etiology of adverse pregnancy outcomes and their long-term impact on cardiometabolic health in women and their children. My current research utilizes large-scale, multi-omics data, under the framework of systems epidemiology, to identify novel risk factors and the underlying mechanisms of adverse pregnancy outcomes and cardiometabolic diseases in women, as well as to examine the (epi)genetic and metabolic bases of the intergenerational link in cardiometabolic disease risk. My research also extends to examining the origin and mechanisms of sex and race differences in cardiometabolic disease risk. I am also leading or participating in multiple consortium metabolomics and (epi)genetics projects in the Trans-Omics for Precision Medicine (TOPMed), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE), and COnsortium of METabolomics Studies (COMETS).

MD, 06/2011, Preventive Medicine
Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

PhD, 06/2016, Environmental Epidemiology
School of Public Health, Huazhong University of Science and Technology, Wuhan, China

Visiting Scholar, 06/2018, Epidemiology
Department of Epidemiology, Brown University School of Public Health, Providence, RI

Research Fellow, 06/2022, Medicine/Women's Health
Division of Women's Health, Brigham and Women's Hospital, Boston, MA

Trudy Bush Fellowship for Cardiovascular Disease Research in Women’s Health
American Heart Association

Semifinalist, Charles J. Epstein Trainee Award for Excellence in Human Genetics Research
American Society of Human Genetics

Early Investigator Travel Award
American Heart Association

Connors-BRI Research Recognition Award
Brigham and Women's Hospital

Reviewers’ Choice Abstract
American Society of Human Genetics


Bibliography

Differences in Metabolomic Profiles Between Black and White Women and Risk of Coronary Heart Disease: an Observational Study of Women From Four US Cohorts.

Hu J, Yao J, Deng S, Balasubramanian R, Jiménez MC, Li J, Guo X, Cruz DE, Gao Y, Huang T, Zeleznik OA, Ngo D, Liu S, Rosal MC, Nassir R, Paynter NP, Albert CM, Tracy RP, Durda P, Liu Y, Taylor KD, Johnson WC, Sun Q, Rimm EB, Eliassen AH, Rich SS, Rotter JI, Gerszten RE, Clish CB, Rexrode KM.

Circ Res. 2022 Sep 16. 131(7):601-615. PMID: 36052690

Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.

Qi Q, Li J, Yu B, Moon JY, Chai JC, Merino J, Hu J, Ruiz-Canela M, Rebholz C, Wang Z, Usyk M, Chen GC, Porneala BC, Wang W, Nguyen NQ, Feofanova EV, Grove ML, Wang TJ, Gerszten RE, Dupuis J, Salas-Salvadó J, Bao W, Perkins DL, Daviglus ML, Thyagarajan B, Cai J, Wang T, Manson JE, Martínez-González MA, Selvin E, Rexrode KM, Clish CB, Hu FB, Meigs JB, Knight R, Burk RD, Boerwinkle E, Kaplan RC.

Gut. 2022 06. 71(6):1095-1105. PMID: 34127525

The Mediterranean diet, plasma metabolome, and cardiovascular disease risk.

Li J, Guasch-Ferré M, Chung W, Ruiz-Canela M, Toledo E, Corella D, Bhupathiraju SN, Tobias DK, Tabung FK, Hu J, Zhao T, Turman C, Feng YA, Clish CB, Mucci L, Eliassen AH, Costenbader KH, Karlson EW, Wolpin BM, Ascherio A, Rimm EB, Manson JE, Qi L, Martínez-González MÁ, Salas-Salvadó J, Hu FB, Liang L.

Eur Heart J. 2020 07 21. 41(28):2645-2656. PMID: 32406924