Quantitative Fluxomics of Circulating Metabolites.
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD.
Cell Metab. 2020 10 06. 32(4):676-688.e4. PMID: 32791100
Faculty Director, Harvard Chan Advanced Multi-omics Platform
Molecular Metabolism
Harvard T.H. Chan School of Public Health
The Hui laboratory aims to answer fundamental questions of energy metabolism and the related diseases: How do individual tissues coordinate their metabolism to achieve overall energy balance of the body? Why can this balance be disrupted by certain perturbations, exhibiting as metabolic diseases (e.g., high-fat diet induces obesity and cancer causes cachexia)? What manipulations can we do to restore the energy balance thus reversing and preventing these diseases?
To answer these questions, we take the approach of in vivo flux quantification by integrating animal experiments, mass spectrometry, and quantitative modeling. Fluxes are the most fundamental functional property of metabolism. Their systematic quantitation holds the potential to transform the field of mammalian physiology. This approach, however, poses two key challenges: (i) need for diverse expertise: animal experiments, analytical chemistry, and mathematical modeling; and (ii) multiple time and length scales involved, from enzymes and their reaction kinetics up to the level of tissue and animal physiology. The lab is unique in having the combination of mathematical and biological skills to successfully tackle these challenges.
BSc, 2002, Physics
Hong Kong Baptist University
MPhil, 2005, Physics
Hong Kong Baptist University
PhD, 2014, Biophysics
University of California San Diego
Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD.
Cell Metab. 2020 10 06. 32(4):676-688.e4. PMID: 32791100
Jang C, Hui S, Zeng X, Cowan AJ, Wang L, Chen L, Morscher RJ, Reyes J, Frezza C, Hwang HY, Imai A, Saito Y, Okamoto K, Vaspoli C, Kasprenski L, Zsido GA, Gorman JH, Gorman RC, Rabinowitz JD.
Cell Metab. 2019 09 03. 30(3):594-606.e3. PMID: 31257152
Neinast MD, Jang C, Hui S, Murashige DS, Chu Q, Morscher RJ, Li X, Zhan L, White E, Anthony TG, Rabinowitz JD, Arany Z.
Cell Metab. 2019 02 05. 29(2):417-429.e4. PMID: 30449684
Jang C, Hui S, Lu W, Cowan AJ, Morscher RJ, Lee G, Liu W, Tesz GJ, Birnbaum MJ, Rabinowitz JD.
Cell Metab. 2018 02 06. 27(2):351-361.e3. PMID: 29414685
Hui S, Ghergurovich JM, Morscher RJ, Jang C, Teng X, Lu W, Esparza LA, Reya T, Yanxiang Guo J, White E, Rabinowitz JD.
Nature. 2017 11 02. 551(7678):115-118. PMID: 29045397
Basan M, Hui S, Okano H, Zhang Z, Shen Y, Williamson JR, Hwa T.
Nature. 2015 Dec 03. 528(7580):99-104. PMID: 26632588
Hui S, Silverman JM, Chen SS, Erickson DW, Basan M, Wang J, Hwa T, Williamson JR.
Mol Syst Biol. 2015 Feb 12. 11(1):784. PMID: 25678603