Shuji Ogino

Professor in the Department of Epidemiology


Other Positions

Professor of Pathology


Brigham and Women's Hospital


Dr. Ogino is Chief, Program in MPE Molecular Pathological Epidemiology of Department of Pathology, Brigham and Women's Hospital, developing the integrative interdisciplinary science of "Molecular Pathological Epidemiology (MPE)". He is an associate member of Broad Institute of MIT and Harvard. He has been serving as Chairperson for The International MPE Meeting Series since 2013. The 4th International Molecular Pathological Epidemiology (MPE) Meeting is planned to be held on May 31 to June 1, 2018 in Boston, MA, USA.

Dr. Ogino's research has a broad theme: Integration of Molecular Pathology, Omics (Genomics), ​Epidemiology, Bioinformatics, and Population Health Science. Dr. Ogino's focus is to develop new scientific disciplines, and develop new data analysis framework and methodologies. The Ogino Lab uses gastrointestinal cancers as model human diseases (including colorectal carcinoma, colorectal polyp, colorectal adenoma, pancreatic adenocarcinoma, neuroendocrine tumor, pancreatic endocrine tumor, carcinoid tumour). We have been analyzing germline and somatic genomics, transcriptomics, epigenomics, and immunomics in human tumors. Using massively parallel sequencing (next generation sequencing) technologies, the Ogino Lab has sequenced whole exome of over 1,000 colorectal carcinomas with high dimensional annotations, and calculated tumor neoantigen load. In addition, the Ogino Lab has obtained data on transcriptome of over 250 colorectal carcinomas (by RNA sequencing).

Dr. Ogino has created a number of new research frameworks, concepts, paradigms, and models, including molecular pathological epidemiology (MPE), the GWAS-MPE approach, the colorectal continuum model, the etiologic field effect model, the causal inference-MPE integration, lifecourse-MPE approach, social MPE, immuno-MPE (immunology-MPE integration), pharmaco-MPE, microbiology-MPE integration, MPE-comparative effectiveness research integration, and nutritional MPE.

AMP Executive Officer's Award
Association for Molecular Pathology (AMP)

USCAP Ramzi Cotran Young Investigator Award
United States and Canadian Academy of Pathology (USCAP)

AMP Meritorious Service Award
Association for Molecular Pathology (AMP)

Most Influential Scientific Minds
Thomson Reuters

ASCI Elected Member2014-pres
American Society for Clinical Investigation (ASCI)

Member, FASEB Excellence in Science Award Committee2014-pres
Federation of American Societies of Experimental Biology (FASEB)

Most Influential Scientific Minds
Thomson Reuters

NCI R35 Outstanding Investigator Award (OIA)2015-pres
National Institute of Health (NIH)

Highly Cited Researcher
Thomson Reuters

Highly Cited Researcher
Clarivate Analytics

ASIP Outstanding Investigator Award
American Society for Investigative Pathology (ASIP)

Highly Cited Researcher
Clarivate Analytics

Runner-up for the Mentor-of-the-Year Award
Dana-Farber Cancer Institute

Invited Nominator for Nobel Prize in Physiology or Medicine 2019, 2020, 20212019-2021
Nobel Committee

Highly Cited Researcher 2019, 20202019-2020
Clarivate Analytics


Spatially organized multicellular immune hubs in human colorectal cancer.

Pelka K, Hofree M, Chen JH, Sarkizova S, Pirl JD, Jorgji V, Bejnood A, Dionne D, Ge WH, Xu KH, Chao SX, Zollinger DR, Lieb DJ, Reeves JW, Fuhrman CA, Hoang ML, Delorey T, Nguyen LT, Waldman J, Klapholz M, Wakiro I, Cohen O, Albers J, Smillie CS, Cuoco MS, Wu J, Su MJ, Yeung J, Vijaykumar B, Magnuson AM, Asinovski N, Moll T, Goder-Reiser MN, Applebaum AS, Brais LK, DelloStritto LK, Denning SL, Phillips ST, Hill EK, Meehan JK, Frederick DT, Sharova T, Kanodia A, Todres EZ, Jané-Valbuena J, Biton M, Izar B, Lambden CD, Clancy TE, Bleday R, Melnitchouk N, Irani J, Kunitake H, Berger DL, Srivastava A, Hornick JL, Ogino S, Rotem A, Vigneau S, Johnson BE, Corcoran RB, Sharpe AH, Kuchroo VK, Ng K, Giannakis M, Nieman LT, Boland GM, Aguirre AJ, Anderson AC, Rozenblatt-Rosen O, Regev A, Hacohen N.

Cell. 2021 Sep 02. 184(18):4734-4752.e20. PMID: 34450029