Secondary Faculty

Shuji Ogino

Professor in the Department of Epidemiology

Epidemiology

sogino@bwh.harvard.edu

Other Positions

Professor of Pathology

Pathology-Brigham and Women's Hospital

Harvard Medical School


Overview

Dr. Ogino is Chief, Program in MPE Molecular Pathological Epidemiology of Department of Pathology, Brigham and Women's Hospital, developing the integrative interdisciplinary science of "Molecular Pathological Epidemiology (MPE)". He is an associate member of Broad Institute of MIT and Harvard. He has been serving as Chairperson for The International MPE Meeting Series since 2013. The 4th International Molecular Pathological Epidemiology (MPE) Meeting is planned to be held on May 31 to June 1, 2018 in Boston, MA, USA.

Dr. Ogino's research has a broad theme: Integration of Molecular Pathology, Omics (Genomics), ​Epidemiology, Bioinformatics, and Population Health Science. Dr. Ogino's focus is to develop new scientific disciplines, and develop new data analysis framework and methodologies. The Ogino Lab uses gastrointestinal cancers as model human diseases (including colorectal carcinoma, colorectal polyp, colorectal adenoma, pancreatic adenocarcinoma, neuroendocrine tumor, pancreatic endocrine tumor, carcinoid tumour). We have been analyzing germline and somatic genomics, transcriptomics, epigenomics, and immunomics in human tumors. Using massively parallel sequencing (next generation sequencing) technologies, the Ogino Lab has sequenced whole exome of over 1,000 colorectal carcinomas with high dimensional annotations, and calculated tumor neoantigen load. In addition, the Ogino Lab has obtained data on transcriptome of over 250 colorectal carcinomas (by RNA sequencing).

Dr. Ogino has created a number of new research frameworks, concepts, paradigms, and models, including molecular pathological epidemiology (MPE), the GWAS-MPE approach, the colorectal continuum model, the etiologic field effect model, the causal inference-MPE integration, lifecourse-MPE approach, social MPE, immuno-MPE (immunology-MPE integration), pharmaco-MPE, microbiology-MPE integration, MPE-comparative effectiveness research integration, and nutritional MPE.

AMP Executive Officer's Award
Association for Molecular Pathology (AMP)

USCAP Ramzi Cotran Young Investigator Award
United States and Canadian Academy of Pathology (USCAP)

AMP Meritorious Service Award
Association for Molecular Pathology (AMP)

Most Influential Scientific Minds
Thomson Reuters

ASCI Elected Member2014-pres
American Society for Clinical Investigation (ASCI)

Member, FASEB Excellence in Science Award Committee2014-pres
Federation of American Societies of Experimental Biology (FASEB)

Most Influential Scientific Minds
Thomson Reuters

NCI R35 Outstanding Investigator Award (OIA)2015-pres
National Institute of Health (NIH)

Highly Cited Researcher
Thomson Reuters

Highly Cited Researcher
Clarivate Analytics

ASIP Outstanding Investigator Award
American Society for Investigative Pathology (ASIP)

Highly Cited Researcher
Clarivate Analytics

Runner-up for the Mentor-of-the-Year Award
Dana-Farber Cancer Institute

Invited Nominator for Nobel Prize in Physiology or Medicine 2019, 2020, 20212019-2021
Nobel Committee

Highly Cited Researcher 2019, 2020, 20212019-2021
Clarivate Analytics


Bibliography

Genome-Wide Interaction Analysis of Genetic Variants With Menopausal Hormone Therapy for Colorectal Cancer Risk.

Tian Y, Kim AE, Bien SA, Lin Y, Qu C, Harrison TA, Carreras-Torres R, Díez-Obrero V, Dimou N, Drew DA, Hidaka A, Huyghe JR, Jordahl KM, Morrison J, Murphy N, Obón-Santacana M, Ulrich CM, Ose J, Peoples AR, Ruiz-Narvaez EA, Shcherbina A, Stern MC, Su YR, van Duijnhoven FJB, Arndt V, Baurley JW, Berndt SI, Bishop DT, Brenner H, Buchanan DD, Chan AT, Figueiredo JC, Gallinger S, Gruber SB, Harlid S, Hoffmeister M, Jenkins MA, Joshi AD, Keku TO, Larsson SC, Le Marchand L, Li L, Giles GG, Milne RL, Nan H, Nassir R, Ogino S, Budiarto A, Platz EA, Potter JD, Prentice RL, Rennert G, Sakoda LC, Schoen RE, Slattery ML, Thibodeau SN, Van Guelpen B, Visvanathan K, White E, Wolk A, Woods MO, Wu AH, Campbell PT, Casey G, Conti DV, Gunter MJ, Kundaje A, Lewinger JP, Moreno V, Newcomb PA, Pardamean B, Thomas DC, Tsilidis KK, Peters U, Gauderman WJ, Hsu L, Chang-Claude J.

J Natl Cancer Inst. 2022 Aug 08. 114(8):1135-1148. PMID: 35512400

Western-Style Diet, Polyketide Synthase (pks) Island-Carrying Escherichia coli, and Colorectal Cancer: Analyses From Two Large Prospective Cohort Studies.

Arima K, Zhong R, Ugai T, Zhao M, Haruki K, Akimoto N, Chan Lau M, Okadome K, Mehta RS, Väyrynen JP, Kishikawa J, Twombly TS, Shi S, Fujiyoshi K, Kosumi K, Ogata Y, Baba H, Wang F, Wu K, Song M, Zhang X, Fuchs CS, Sears CL, Willett WC, Giovannucci EL, Meyerhardt JA, Garrett WS, Huttenhower C, Chan AT, Nowak JA, Giannakis M, Ogino S.

Gastroenterology. 2022 Jun 24. PMID: 35760086

Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures.

Georgeson P, Harrison TA, Pope BJ, Zaidi SH, Qu C, Steinfelder RS, Lin Y, Joo JE, Mahmood K, Clendenning M, Walker R, Amitay EL, Berndt SI, Brenner H, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Doheny KF, Drew DA, Figueiredo JC, French AJ, Gallinger S, Giannakis M, Giles GG, Gsur A, Gunter MJ, Hoffmeister M, Hsu L, Huang WY, Limburg P, Manson JE, Moreno V, Nassir R, Nowak JA, Obón-Santacana M, Ogino S, Phipps AI, Potter JD, Schoen RE, Sun W, Toland AE, Trinh QM, Ugai T, Macrae FA, Rosty C, Hudson TJ, Jenkins MA, Thibodeau SN, Winship IM, Peters U, Buchanan DD.

Nat Commun. 2022 06 06. 13(1):3254. PMID: 35668106


News

Cancer rising in people under 50  

Incidence of early onset cancers—including breast, colon, esophagus, kidney, liver, and pancreas—has been dramatically increasing around the world since 1990.