Secondary Faculty

Susan Redline

Professor in the Department of Epidemiology


Other Positions

Peter C. Farrell Professor of Sleep Medicine

Medicine-Brigham and Women's Hospital

Harvard Medical School


I direct the Program in Sleep Medicine Epidemiology at BWH. Our goals are to conduct rigorous and population-based research to: elucidate the role of genetics, early life developmental factors, and environmental exposures on sleep health; identify how social and environmental factors shape sleep health disparities which in turn drive chronic health disparities; and identify the role of sleep interventions in improving health, including cardiovascular, metabolic, and cognitive disorders.

Within the Program, we support the following Resources:

The BWH Sleep Reading Center (, an international core laboratory that provides leadership in the design and implementation of sleep data collection for numerous clinical trials and cohort studies. It spearheaded efforts at establishing rigorous quality control procedures for multi-site sleep research and for integrating advanced signal processing analytics into large scale-epidemiological datasets to provide quantitative biomarkers of sleep and sleep disorders.

The National Sleep Research Resource (NSRR;, a NHLBI-data and tool repository and community engagement resource that shares large quantities of polysomnography, actigraphy and other data coupled with tools to structure, harmonize, visualize and analyze sleep data.

The Sleep Apnea Patient-Centered Outcomes Network (MyApnea;, a web-based portal to promote sleep apnea patient support and patient engagement in research.

I am the recipient of a NHLBI Outstanding Investigator Award (R35) that supports a research and training program, Phenotypic and Genomic Signatures For Sleep Apnea. This program brings together trainees and experts in epidemiology, genetic and sleep/respiratory physiology to identify biomarkers and molecular mechanisms for sleep apnea risk, models interactions between sleep disorders and genetic risk factors (G*E), and attempts to resolve the heterogeneity in sleep apnea that predicts differences in outcomes and treatment response.

I co-direct the following multi-center clinical trials:
Pediatric Adenotonsillectomy Trial (PATS;
Impact of Low Flow Oxygen on Hospital Admissions and Mortality in Heart Failure and Central Sleep Apnea (LOFT-HF;

I co-lead a cohort study examining the impact of the home environment on sleep disorders among children in low income urban neighborhoods. (Environmental Assessment of Sleep in Youth).

BA, 05/1979, Six Year Medical Honors Program
Boston University, Boston

MD, 05/1979, Medicine
Boston University School of Medicine, Boston

MPH, 05/1986, Respiratory Epidemiology
Harvard School Of Public Health, Boston

William C Dement Scientific Achievement Award2017
American Academy of Sleep Medicine

Scientific Recognition Award2012
American Thoracic Society

Association of American Physicians2008

Sleep In Infancy and Childhood Award2008

Spotlight on Women's Scholarship2007
Case Western Reserve University


Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing.

Jakubek YA, Zhou Y, Stilp A, Bacon J, Wong JW, Ozcan Z, Arnett D, Barnes K, Bis JC, Boerwinkle E, Brody JA, Carson AP, Chasman DI, Chen J, Cho M, Conomos MP, Cox N, Doyle MF, Fornage M, Guo X, Kardia SLR, Lewis JP, Loos RJF, Ma X, Machiela MJ, Mack TM, Mathias RA, Mitchell BD, Mychaleckyj JC, North K, Pankratz N, Peyser PA, Preuss MH, Psaty B, Raffield LM, Vasan RS, Redline S, Rich SS, Rotter JI, Silverman EK, Smith JA, Smith AP, Taub M, Taylor KD, Yun J, Li Y, Desai P, Bick AG, Reiner AP, Scheet P, Auer PL.

Nat Genet. 2023 Nov. 55(11):1912-1919. PMID: 37904051

Determinants of mosaic chromosomal alteration fitness.

Pershad Y, Mack T, Poisner H, Jakubek YA, Stilp AM, Mitchell BD, Lewis JP, Boerwinkle E, Loos RJ, Chami N, Wang Z, Barnes K, Pankratz N, Fornage M, Redline S, Psaty BM, Bis JC, Shojaie A, Silverman EK, Cho MH, Yun J, DeMeo D, Levy D, Johnson A, Mathias R, Taub M, Arnett D, North K, Raffield LM, Carson A, Doyle MF, Rich SS, Rotter JI, Guo X, Cox N, Roden DM, Franceschini N, Desai P, Reiner A, Auer PL, Scheet P, Jaiswal S, Weinstock JS, Bick AG.

medRxiv. 2023 Oct 21. PMID: 37905118

Rare variants in long non-coding RNAs are associated with blood lipid levels in the TOPMed whole-genome sequencing study.

Wang Y, Selvaraj MS, Li X, Li Z, Holdcraft JA, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Cade BE, Carlson JC, Carson AP, Chen YI, Curran JE, de Vries PS, Dutcher SK, Ellinor PT, Floyd JS, Fornage M, Freedman BI, Gabriel S, Germer S, Gibbs RA, Guo X, He J, Heard-Costa N, Hildalgo B, Hou L, Irvin MR, Joehanes R, Kaplan RC, Kardia SL, Kelly TN, Kim R, Kooperberg C, Kral BG, Levy D, Li C, Liu C, Lloyd-Jone D, Loos RJ, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Murabito JM, Naseri T, O'Connell JR, Palmer ND, Preuss MH, Psaty BM, Raffield LM, Rao DC, Redline S, Reiner AP, Rich SS, Ruepena MS, Sheu WH, Smith JA, Smith A, Tiwari HK, Tsai MY, Viaud-Martinez KA, Wang Z, Yanek LR, Zhao W, Rotter JI, Lin X, Natarajan P, Peloso GM.

Am J Hum Genet. 2023 Oct 05. 110(10):1704-1717. PMID: 37802043


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