Obstructive sleep apnoea heterogeneity and cardiovascular disease.
Redline S, Azarbarzin A, Peker Y.
Nat Rev Cardiol. 2023 Mar 10. PMID: 36899115
I direct the Program in Sleep Medicine Epidemiology at BWH. Our goals are to conduct rigorous and population-based research to: elucidate the role of genetics, early life developmental factors, and environmental exposures on sleep health; identify how social and environmental factors shape sleep health disparities which in turn drive chronic health disparities; and identify the role of sleep interventions in improving health, including cardiovascular, metabolic, and cognitive disorders.
Within the Program, we support the following Resources:
The BWH Sleep Reading Center (www.bostonsleep.org), an international core laboratory that provides leadership in the design and implementation of sleep data collection for numerous clinical trials and cohort studies. It spearheaded efforts at establishing rigorous quality control procedures for multi-site sleep research and for integrating advanced signal processing analytics into large scale-epidemiological datasets to provide quantitative biomarkers of sleep and sleep disorders.
The National Sleep Research Resource (NSRR; www.sleepdata.org), a NHLBI-data and tool repository and community engagement resource that shares large quantities of polysomnography, actigraphy and other data coupled with tools to structure, harmonize, visualize and analyze sleep data.
The Sleep Apnea Patient-Centered Outcomes Network (MyApnea; www.myapnea.org), a web-based portal to promote sleep apnea patient support and patient engagement in research.
I am the recipient of a NHLBI Outstanding Investigator Award (R35) that supports a research and training program, Phenotypic and Genomic Signatures For Sleep Apnea. This program brings together trainees and experts in epidemiology, genetic and sleep/respiratory physiology to identify biomarkers and molecular mechanisms for sleep apnea risk, models interactions between sleep disorders and genetic risk factors (G*E), and attempts to resolve the heterogeneity in sleep apnea that predicts differences in outcomes and treatment response.
I co-direct the following multi-center clinical trials:
Pediatric Adenotonsillectomy Trial (PATS; patstrial.org)
Impact of Low Flow Oxygen on Hospital Admissions and Mortality in Heart Failure and Central Sleep Apnea (LOFT-HF; lofthf.study).
I co-lead a cohort study examining the impact of the home environment on sleep disorders among children in low income urban neighborhoods. (Environmental Assessment of Sleep in Youth).
BA, 05/1979, Six Year Medical Honors Program
Boston University, Boston
MD, 05/1979, Medicine
Boston University School of Medicine, Boston
MPH, 05/1986, Respiratory Epidemiology
Harvard School Of Public Health, Boston
Spotlight on Women's Scholarship
Case Western Reserve University
Association of American Physicians
Sleep In Infancy and Childhood Award
Annenberg
Scientific Recognition Award
American Thoracic Society
William C Dement Scientific Achievement Award
American Academy of Sleep Medicine
Redline S, Azarbarzin A, Peker Y.
Nat Rev Cardiol. 2023 Mar 10. PMID: 36899115
Hartmann S, Parrino L, Ensrud K, Stone KL, Redline S, Clark SR, Baumert M.
J Clin Sleep Med. 2023 Mar 01. 19(3):581-589. PMID: 36546402
Sands SA, Alex RM, Mann D, Vena D, Terrill PI, Gell LK, Zinchuk A, Sofer T, Patel SR, Taranto-Montemurro L, Azarbarzin A, Rueschman M, White DP, Wellman A, Redline S.
Ann Am Thorac Soc. 2023 03. 20(3):440-449. PMID: 36287615
Ryu S, Morey BN, Lee GE, Kawachi I, Redline S, Lee S.
Am J Epidemiol. 2023 02 24. 192(3):420-429. PMID: 36516987
Cade BE, Hassan SM, Mullington JM, Karlson EW, Redline S.
medRxiv. 2023 Feb 23. PMID: 36865276
Eulenburg C, Celik Y, Redline S, Thunström E, Glantz H, Strollo PJ, Peker Y.
Ann Am Thorac Soc. 2023 Feb 17. PMID: 36800433
Full KM, Huang T, Shah NA, Allison MA, Michos ED, Duprez DA, Redline S, Lutsey PL.
J Am Heart Assoc. 2023 Feb 21. 12(4):e027361. PMID: 36789869
Kim JS, Azarbarzin A, Podolanczuk AJ, Anderson MR, Cade BE, Kawut SM, Wysoczanski A, Laine AF, Hoffman EA, Gottlieb DJ, Garcia CK, Barr RG, Redline S.
Ann Am Thorac Soc. 2023 Feb 15. PMID: 36790913
Haghayegh S, Hu K, Stone K, Redline S, Schernhammer E.
J Med Internet Res. 2023 02 10. 25:e40211. PMID: 36763454
Kurniansyah N, Wallace DA, Zhang Y, Yu B, Cade B, Wang H, Ochs-Balcom HM, Reiner AP, Ramos AR, Smith JD, Cai J, Daviglus M, Zee PC, Kaplan R, Kooperberg C, Rich SS, Rotter JI, Gharib SA, Redline S, Sofer T.
Commun Biol. 2023 01 31. 6(1):125. PMID: 36721044
Insomnia, sleep apnea, snoring, and other sleep difficulties common among older adults are more common among blacks, Chinese, and Hispanics in America than in whites and may contribute to health disparities, according to a study led by Harvard…
Harvard Catalyst fosters relationships across the University June 26, 2014 — Fathers tend not to be included in research on how kids are fed at home, despite increasing evidence that men are contributing more time to the daily…