The microbiome and rise of early-onset cancers: knowledge gaps and research opportunities.
Mima K, Hamada T, Inamura K, Baba H, Ugai T, Ogino S.
Gut Microbes. 2023 12. 15(2):2269623. PMID: 37902043
Other Positions
Instructor in Pathology
Pathology-Brigham and Women's Hospital
Harvard Medical School
Links
Overview
Dr. Ugai is a junior faculty member at Brigham and Women's Hospital/Harvard Medical School and an MD/PhD physician scientist with expertise in pathology, clinical oncology, cancer epidemiology, and molecular epidemiology. His current research focuses on early-onset cancers and tumor biomarkers, including immune and microbial characteristics of cancer. Dr. Ugai is a founder of the Cancer Spectrum Epidemiology Working Group, an interdisciplinary working group with faculty, postdocs, and students from various institutions all over the world. Dr. Ugai's group aims to build up a resource that integrates lifestyles and biomarkers including genetics and tissue molecular markers to (a) develop effective prevention and early-detection strategies, and (b) identify novel biomarkers to guide early-stage clinical decisions.
AACR Scholar-in-Training Award for AACR Annual Meeting 2023
American Association for Cancer Research
Brigham and Women's Hospital Faculty Career Development Award
Brigham and Women's Hospital
MPE Rising Faculty Investigator Award
The 6th International MPE Meeting
Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics
Harvard Th. Chan School of Public Health
AACR Scholar-in-Training Award for AACR Special Conference: Colorectal Cancer
American Association for Cancer Research
Harvey V. Fineberg Fellowship in Cancer Prevention
Harvard Th. Chan School of Public Health
AACR Scholar-in-Training Award for AACR Annual Meeting 2022
American Association for Cancer Research
Japanese Cancer Association Young Investigator Award
Japanese Cancer Association
Bibliography
Mumps vaccine hesitancy: Current evidence and an evidence-based campaign in Japan.
Ugai S, Ugai T, Kanayama T, Kamiya H, Saitoh A, Slopen N.
Vaccine. 2023 09 22. 41(41):6036-6041. PMID: 37640569
Inverse relationship between Fusobacterium nucleatum amount and tumor CD274 (PD-L1) expression in colorectal carcinoma.
Ugai T, Shimizu T, Kawamura H, Ugai S, Takashima Y, Usui G, Väyrynen JP, Okadome K, Haruki K, Akimoto N, Masugi Y, da Silva A, Mima K, Zhang X, Chan AT, Wang M, Garrett WS, Freeman GJ, Meyerhardt JA, Nowak JA, Song M, Giannakis M, Ogino S.
Clin Transl Immunology. 2023. 12(8):e1453. PMID: 37538192
Bayesian risk prediction model for colorectal cancer mortality through integration of clinicopathologic and genomic data.
Zhao M, Lau MC, Haruki K, Väyrynen JP, Gurjao C, Väyrynen SA, Dias Costa A, Borowsky J, Fujiyoshi K, Arima K, Hamada T, Lennerz JK, Fuchs CS, Nishihara R, Chan AT, Ng K, Zhang X, Meyerhardt JA, Song M, Wang M, Giannakis M, Nowak JA, Yu KH, Ugai T, Ogino S.
NPJ Precis Oncol. 2023 Jun 10. 7(1):57. PMID: 37301916
Histopathology images predict multi-omics aberrations and prognoses in colorectal cancer patients.
Tsai PC, Lee TH, Kuo KC, Su FY, Lee TM, Marostica E, Ugai T, Zhao M, Lau MC, Väyrynen JP, Giannakis M, Takashima Y, Kahaki SM, Wu K, Song M, Meyerhardt JA, Chan AT, Chiang JH, Nowak J, Ogino S, Yu KH.
Nat Commun. 2023 04 13. 14(1):2102. PMID: 37055393
Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.
Georgeson P, Steinfelder RS, Harrison TA, Pope BJ, Zaidi SH, Qu C, Lin Y, Joo JE, Mahmood K, Clendenning M, Walker R, Aglago EK, Berndt SI, Brenner H, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Dimou N, Doheny KF, Drew DA, Figueiredo JC, French AJ, Gallinger S, Giannakis M, Giles GG, Goode EL, Gruber SB, Gsur A, Gunter MJ, Harlid S, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Manson JE, Moreno V, Murphy N, Nassir R, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pai RK, Papadimitrou N, Potter JD, Schoen RE, Song M, Sun W, Toland AE, Trinh QM, Tsilidis K, Ugai T, Um CY, Macrae FA, Rosty C, Hudson TJ, Winship IM, Phipps AI, Jenkins MA, Peters U, Buchanan DD.
medRxiv. 2023 Mar 12. PMID: 37090539
Body mass index and molecular subtypes of colorectal cancer.
Murphy N, Newton CC, Song M, Papadimitriou N, Hoffmeister M, Phipps AI, Harrison TA, Newcomb PA, Aglago EK, Berndt SI, Brenner H, Buchanan DD, Cao Y, Chan AT, Chen X, Cheng I, Chang-Claude J, Dimou N, Drew D, Farris AB, French AJ, Gallinger S, Georgeson P, Giannakis M, Giles GG, Gruber SB, Harlid S, Hsu L, Huang WY, Jenkins MA, Laskar RS, Le Marchand L, Limburg P, Lin Y, Mandic M, Nowak JA, Obón-Santacana M, Ogino S, Qu C, Sakoda LC, Schoen RE, Southey MC, Stadler ZK, Steinfelder RS, Sun W, Thibodeau SN, Toland AE, Trinh QM, Tsilidis KK, Ugai T, Van Guelpen B, Wang X, Woods MO, Zaidi SH, Gunter MJ, Peters U, Campbell PT.
J Natl Cancer Inst. 2023 02 08. 115(2):165-173. PMID: 36445035
Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.
Ugai T, Akimoto N, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, Campbell PT, Berndt SI, Buchanan DD, Cross AJ, Diergaarde B, Gallinger SJ, Gunter MJ, Harlid S, Hidaka A, Hoffmeister M, Brenner H, Chang-Claude J, Hsu L, Jenkins MA, Lin Y, Milne RL, Moreno V, Newcomb PA, Nishihara R, Obon-Santacana M, Pai RK, Sakoda LC, Schoen RE, Slattery ML, Sun W, Amitay EL, Alwers E, Thibodeau SN, Toland AE, Van Guelpen B, Zaidi SH, Potter JD, Meyerhardt JA, Giannakis M, Song M, Nowak JA, Peters U, Phipps AI, Ogino S.
J Gastroenterol. 2023 03. 58(3):229-245. PMID: 36648535
Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.
Ugai T, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, Campbell PT, Akimoto N, Berndt S, Brenner H, Buchanan DD, Chang-Claude J, Fujiyoshi K, Gallinger SJ, Gunter MJ, Hidaka A, Hoffmeister M, Hsu L, Jenkins MA, Milne RL, Moreno V, Newcomb PA, Nishihara R, Pai RK, Sakoda LC, Slattery ML, Sun W, Amitay EL, Alwers E, Thibodeau SN, Toland AE, Van Guelpen B, Woods MO, Zaidi SH, Potter JD, Giannakis M, Song M, Nowak JA, Phipps AI, Peters U, Ogino S.
Am J Gastroenterol. 2023 04 01. 118(4):712-726. PMID: 36707929
Prognostic role of inflammatory diets in colorectal cancer overall and in strata of tumor-infiltrating lymphocyte levels.
Ugai T, Liu L, Tabung FK, Hamada T, Langworthy BW, Akimoto N, Haruki K, Takashima Y, Okadome K, Kawamura H, Zhao M, Kahaki SMM, Glickman JN, Lennerz JK, Zhang X, Chan AT, Fuchs CS, Song M, Wang M, Yu KH, Giannakis M, Nowak JA, Meyerhardt JA, Wu K, Ogino S, Giovannucci EL.
Clin Transl Med. 2022 11. 12(11):e1114. PMID: 36437503
News
Lifestyle changes may be driving higher cancer rates in people under 50
Cancers are on the rise among people younger than 50, and experts think that lifestyle changes may have something to do with it—although data is not firm.
Cancer rising in people under 50
Incidence of early onset cancers—including breast, colon, esophagus, kidney, liver, and pancreas—has been dramatically increasing around the world since 1990.
