Tomotaka Ugai

Department Associate

Epidemiology

tugai@hsph.harvard.edu

Other Positions

Instructor in Pathology

Pathology-Brigham and Women's Hospital

Harvard Medical School


Overview

Dr. Ugai is a junior faculty member at Brigham and Women's Hospital/Harvard Medical School and an MD/PhD physician scientist with expertise in pathology, clinical oncology, cancer epidemiology, and molecular epidemiology. His current research focuses on early-onset cancers and tumor biomarkers, including immune and microbial characteristics of cancer. Dr. Ugai is a founder of the Cancer Spectrum Epidemiology Working Group, an interdisciplinary working group with faculty, postdocs, and students from various institutions all over the world. Dr. Ugai's group aims to build up a resource that integrates lifestyles and biomarkers including genetics and tissue molecular markers to (a) develop effective prevention and early-detection strategies, and (b) identify novel biomarkers to guide early-stage clinical decisions.

AACR Scholar-in-Training Award for AACR Annual Meeting 20232023
American Association for Cancer Research

Brigham and Women's Hospital Faculty Career Development Award2023
Brigham and Women's Hospital

MPE Rising Faculty Investigator Award2023
The 6th International MPE Meeting

Rose Traveling Fellowship Program in Chronic Disease Epidemiology and Biostatistics2022
Harvard Th. Chan School of Public Health

AACR Scholar-in-Training Award for AACR Special Conference: Colorectal Cancer2022
American Association for Cancer Research

Harvey V. Fineberg Fellowship in Cancer Prevention2022
Harvard Th. Chan School of Public Health

AACR Scholar-in-Training Award for AACR Annual Meeting 20222022
American Association for Cancer Research

Japanese Cancer Association Young Investigator Award2021
Japanese Cancer Association


Bibliography

Genotoxic colibactin mutational signature in colorectal cancer is associated with clinicopathological features, specific genomic alterations and better survival.

Georgeson P, Steinfelder RS, Harrison TA, Pope BJ, Zaidi SH, Qu C, Lin Y, Joo JE, Mahmood K, Clendenning M, Walker R, Aglago EK, Berndt SI, Brenner H, Campbell PT, Cao Y, Chan AT, Chang-Claude J, Dimou N, Doheny KF, Drew DA, Figueiredo JC, French AJ, Gallinger S, Giannakis M, Giles GG, Goode EL, Gruber SB, Gsur A, Gunter MJ, Harlid S, Hoffmeister M, Hsu L, Huang WY, Huyghe JR, Manson JE, Moreno V, Murphy N, Nassir R, Newton CC, Nowak JA, Obón-Santacana M, Ogino S, Pai RK, Papadimitrou N, Potter JD, Schoen RE, Song M, Sun W, Toland AE, Trinh QM, Tsilidis K, Ugai T, Um CY, Macrae FA, Rosty C, Hudson TJ, Winship IM, Phipps AI, Jenkins MA, Peters U, Buchanan DD.

medRxiv. 2023 Mar 12. PMID: 37090539

Body mass index and molecular subtypes of colorectal cancer.

Murphy N, Newton CC, Song M, Papadimitriou N, Hoffmeister M, Phipps AI, Harrison TA, Newcomb PA, Aglago EK, Berndt SI, Brenner H, Buchanan DD, Cao Y, Chan AT, Chen X, Cheng I, Chang-Claude J, Dimou N, Drew D, Farris AB, French AJ, Gallinger S, Georgeson P, Giannakis M, Giles GG, Gruber SB, Harlid S, Hsu L, Huang WY, Jenkins MA, Laskar RS, Le Marchand L, Limburg P, Lin Y, Mandic M, Nowak JA, Obón-Santacana M, Ogino S, Qu C, Sakoda LC, Schoen RE, Southey MC, Stadler ZK, Steinfelder RS, Sun W, Thibodeau SN, Toland AE, Trinh QM, Tsilidis KK, Ugai T, Van Guelpen B, Wang X, Woods MO, Zaidi SH, Gunter MJ, Peters U, Campbell PT.

J Natl Cancer Inst. 2023 02 08. 115(2):165-173. PMID: 36445035

Prognostic role of detailed colorectal location and tumor molecular features: analyses of 13,101 colorectal cancer patients including 2994 early-onset cases.

Ugai T, Akimoto N, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, Campbell PT, Berndt SI, Buchanan DD, Cross AJ, Diergaarde B, Gallinger SJ, Gunter MJ, Harlid S, Hidaka A, Hoffmeister M, Brenner H, Chang-Claude J, Hsu L, Jenkins MA, Lin Y, Milne RL, Moreno V, Newcomb PA, Nishihara R, Obon-Santacana M, Pai RK, Sakoda LC, Schoen RE, Slattery ML, Sun W, Amitay EL, Alwers E, Thibodeau SN, Toland AE, Van Guelpen B, Zaidi SH, Potter JD, Meyerhardt JA, Giannakis M, Song M, Nowak JA, Peters U, Phipps AI, Ogino S.

J Gastroenterol. 2023 03. 58(3):229-245. PMID: 36648535

Molecular Characteristics of Early-Onset Colorectal Cancer According to Detailed Anatomical Locations: Comparison With Later-Onset Cases.

Ugai T, Haruki K, Harrison TA, Cao Y, Qu C, Chan AT, Campbell PT, Akimoto N, Berndt S, Brenner H, Buchanan DD, Chang-Claude J, Fujiyoshi K, Gallinger SJ, Gunter MJ, Hidaka A, Hoffmeister M, Hsu L, Jenkins MA, Milne RL, Moreno V, Newcomb PA, Nishihara R, Pai RK, Sakoda LC, Slattery ML, Sun W, Amitay EL, Alwers E, Thibodeau SN, Toland AE, Van Guelpen B, Woods MO, Zaidi SH, Potter JD, Giannakis M, Song M, Nowak JA, Phipps AI, Peters U, Ogino S.

Am J Gastroenterol. 2023 04 01. 118(4):712-726. PMID: 36707929


News

Cancer rising in people under 50  

Incidence of early onset cancers—including breast, colon, esophagus, kidney, liver, and pancreas—has been dramatically increasing around the world since 1990.