Novel Imaging Tools to Study Mitochondrial Dynamics in Caenorhabditis elegans.
Valera-Alberni M, Yao P, Romero-Sanz S, Lanjuin A, Mair WB.
bioRxiv. 2024 Jul 16. PMID: 39071403
Primary Faculty
William B Mair
Other Positions
Director of the Harvard Chan School Aging Initiative
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Overview
Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.
In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.
http://www.hsph.harvard.edu/william-mair/
Bibliography
An Intricate Network Involving the Argonaute ALG-1 Modulates Organismal Resistance to Oxidative Stress.
Vergani-Junior CA, Moro RP, Pinto S, De-Souza EA, Camara H, Braga DL, Tonon-da-Silva G, Knittel TL, Ruiz GP, Ludwig RG, Massirer KB, Mair WB, Mori MA.
Nat Commun. 2024 Apr 09. 15(1):3070. PMID: 38594249
Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.
Stojanovski K, Gheorghe I, Lenart P, Lanjuin A, Mair WB, Towbin BD.
Nat Commun. 2023 Nov 20. 14(1):7564. PMID: 37985670
The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans.
Silva-García CG, Láscarez-Lagunas LI, Papsdorf K, Heintz C, Prabhakar A, Morrow CS, Pajuelo Torres L, Sharma A, Liu J, Colaiácovo MP, Brunet A, Mair WB.
Nat Aging. 2023 Nov. 3(11):1358-1371. PMID: 37946042
Author Correction: Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A.
Nat Cell Biol. 2023 Oct. 25(10):1547. PMID: 37567997
Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans.
Smith HJ, Lanjuin A, Sharma A, Prabhakar A, Nowak E, Stine PG, Sehgal R, Stojanovski K, Towbin BD, Mair WB.
PLoS Genet. 2023 Sep. 19(9):e1010938. PMID: 37721956
Fast fragmenting mitochondria by TORC2.
Valera-Alberni M, Mair WB.
Nat Cell Biol. 2023 Jul. 25(7):926-927. PMID: 37386152
Lipid droplets and peroxisomes are co-regulated to drive lifespan extension in response to mono-unsaturated fatty acids.
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A.
Nat Cell Biol. 2023 05. 25(5):672-684. PMID: 37127715
A single-copy knockin translating ribosome immunoprecipitation toolkit for tissue-specific profiling of actively translated mRNAs in C. elegans.
Wester LE, Lanjuin A, Bruckisch EHW, Perez-Matos MC, Stine PG, Heintz C, Denzel MS, Mair WB.
Cell Rep Methods. 2023 03 27. 3(3):100433. PMID: 37056370
Lysosome lipid signalling from the periphery to neurons regulates longevity.
Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC.
Nat Cell Biol. 2022 06. 24(6):906-916. PMID: 35681008
News
Frontlines Fall 2021
Quick updates about the latest public health news from across the School and beyond.
Aging matters
Sneha Dutta, PhD ’21, wants to understand why individuals age differently and if there’s a way to counter old age’s harmful effects.
There’s no single pathway into science, panelists tell teens
Experts from Harvard Chan School's Department of Molecular Metabolism shared information about science careers at a digital panel discussion for teens.
Challenging myths about aging
As populations age around the globe, leading to more chronic disease and human suffering, interest has surged in what causes aging and what might be done to alleviate its effects. But some myths about aging persist even though…
William Mair receives 2019 Armen H. Tashjian Jr. Award
May 15, 2019—William Mair, associate professor of genetics and complex diseases at Harvard T.H. Chan School of Public Health, is the 2019 recipient of the Armen H. Tashjian Jr. Award for Excellence in Endocrine Research. Brendan Manning, professor…
