Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1.
Stojanovski K, Gheorghe I, Lenart P, Lanjuin A, Mair WB, Towbin BD.
Nat Commun. 2023 Nov 20. 14(1):7564. PMID: 37985670
Aging is a universal trait that is observed across the evolutionary spectrum. From a public health perspective, aging is also the critical risk factor for a variety of human pathologies, including neurodegenerative diseases, many forms of cancer and metabolic disease. Our lab is interested in understanding the molecular pathways underpinning the aging process, with the goal of using this knowledge to develop novel therapeutic strategies to treat age-onset disorders.
In particular, we study the mechanisms by which animals can modulate the rate at which they age in response to changes in nutrition and the environment. The profound ability to slow aging when energy availability is low is seen in organisms ranging from yeast to primates and is coupled to a striking protection against a suite of age-related pathologies. By elucidating the genetic and molecular pathways that dictate this response, we aim to recapitulate the positive effects of dietary restriction on lifespan and health without the need for changes in dietary intake and its associated detrimental side effects.
http://www.hsph.harvard.edu/william-mair/
Stojanovski K, Gheorghe I, Lenart P, Lanjuin A, Mair WB, Towbin BD.
Nat Commun. 2023 Nov 20. 14(1):7564. PMID: 37985670
Silva-García CG, Láscarez-Lagunas LI, Papsdorf K, Heintz C, Prabhakar A, Morrow CS, Pajuelo Torres L, Sharma A, Liu J, Colaiácovo MP, Brunet A, Mair WB.
Nat Aging. 2023 Nov. 3(11):1358-1371. PMID: 37946042
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A.
Nat Cell Biol. 2023 Oct. 25(10):1547. PMID: 37567997
Smith HJ, Lanjuin A, Sharma A, Prabhakar A, Nowak E, Stine PG, Sehgal R, Stojanovski K, Towbin BD, Mair WB.
PLoS Genet. 2023 Sep. 19(9):e1010938. PMID: 37721956
Valera-Alberni M, Mair WB.
Nat Cell Biol. 2023 Jul. 25(7):926-927. PMID: 37386152
Papsdorf K, Miklas JW, Hosseini A, Cabruja M, Morrow CS, Savini M, Yu Y, Silva-García CG, Haseley NR, Murphy LM, Yao P, de Launoit E, Dixon SJ, Snyder MP, Wang MC, Mair WB, Brunet A.
Nat Cell Biol. 2023 05. 25(5):672-684. PMID: 37127715
Wester LE, Lanjuin A, Bruckisch EHW, Perez-Matos MC, Stine PG, Heintz C, Denzel MS, Mair WB.
Cell Rep Methods. 2023 03 27. 3(3):100433. PMID: 37056370
Savini M, Folick A, Lee YT, Jin F, Cuevas A, Tillman MC, Duffy JD, Zhao Q, Neve IA, Hu PW, Yu Y, Zhang Q, Ye Y, Mair WB, Wang J, Han L, Ortlund EA, Wang MC.
Nat Cell Biol. 2022 06. 24(6):906-916. PMID: 35681008
Nwanaji-Enwerem JC, Mair WB.
Lancet Healthy Longev. 2022 Jun. 3(6):e376-e377. PMID: 36034882
Statzer C, Meng J, Venz R, Bland M, Robida-Stubbs S, Patel K, Petrovic D, Emsley R, Liu P, Morantte I, Haynes C, Mair WB, Longchamp A, Filipovic MR, Blackwell TK, Ewald CY.
Nat Commun. 2022 02 18. 13(1):967. PMID: 35181679
Quick updates about the latest public health news from across the School and beyond.
Sneha Dutta, PhD ’21, wants to understand why individuals age differently and if there’s a way to counter old age’s harmful effects May 18, 2021–As a master’s student studying biology at the Tata Institute of Fundamental Research in…
February 11, 2021–Ask loads of questions, follow your interests, and embrace failure. Those are just a few of the career tips members of the Department of Molecular Metabolism (MET) shared during a February 3, 2020 “Meet the Scientists”…
As populations age around the globe, leading to more chronic disease and human suffering, interest has surged in what causes aging and what might be done to alleviate its effects. But some myths about aging persist even though…
May 15, 2019—William Mair, associate professor of genetics and complex diseases at Harvard T.H. Chan School of Public Health, is the 2019 recipient of the Armen H. Tashjian Jr. Award for Excellence in Endocrine Research. Brendan Manning, professor…