William P. Hanage
Associate Professor

William P. Hanage

Associate Professor of Epidemiology

Epidemiology

whanage@hsph.harvard.edu


Overview

I am an Associate Professor of Epidemiology in the department of Epidemiology, and a faculty member in the Center for Communicable Disease Dynamics. I employ a mix of theoretical and laboratory work to research the evolution and epidemiology of infectious disease. After my PhD, I did post doctoral study at the University of Oxford and Imperial College London, before being awarded a Royal Society University Research Fellowship. Prior to joining the Center for Communicable Disease Dynamics, I was a Reader in the department of Infectious Disease Epidemiology at Imperial College London. There I worked extensively developing multilocus sequence typing (MLST; www.mlst.net) and analysis (MLSA) for the study of bacterial pathogens and species, as well as means of analyzing data developed using this method. I am particularly interested in using an evolutionary framework such as methods derived from population genetics to inform epidemiology. In 2012 I received the Fleming Prize for research in Microbiology and was the recipient of a 2012 ICAAC Young Investigator Award from the American Society for Microbiology.


Bibliography

Phylogenetic analysis of SARS-CoV-2 in Boston highlights the impact of superspreading events.

Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda JA, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, MacInnis BL.

Science. 2020 Dec 10. PMID: 33303686

Persistence and Evolution of SARS-CoV-2 in an Immunocompromised Host.

Choi B, Choudhary MC, Regan J, Sparks JA, Padera RF, Qiu X, Solomon IH, Kuo HH, Boucau J, Bowman K, Adhikari UD, Winkler ML, Mueller AA, Hsu TY, Desjardins M, Baden LR, Chan BT, Walker BD, Lichterfeld M, Brigl M, Kwon DS, Kanjilal S, Richardson ET, Jonsson AH, Alter G, Barczak AK, Hanage WP, Yu XG, Gaiha GD, Seaman MS, Cernadas M, Li JZ.

N Engl J Med. 2020 12 03. 383(23):2291-2293. PMID: 33176080

Scientific consensus on the COVID-19 pandemic: we need to act now.

Alwan NA, Burgess RA, Ashworth S, Beale R, Bhadelia N, Bogaert D, Dowd J, Eckerle I, Goldman LR, Greenhalgh T, Gurdasani D, Hamdy A, Hanage WP, Hodcroft EB, Hyde Z, Kellam P, Kelly-Irving M, Krammer F, Lipsitch M, McNally A, McKee M, Nouri A, Pimenta D, Priesemann V, Rutter H, Silver J, Sridhar D, Swanton C, Walensky RP, Yamey G, Ziauddeen H.

Lancet. 2020 10 31. 396(10260):e71-e72. PMID: 33069277

Phylogenetic analysis of SARS-CoV-2 in the Boston area highlights the role of recurrent importation and superspreading events.

Lemieux JE, Siddle KJ, Shaw BM, Loreth C, Schaffner SF, Gladden-Young A, Adams G, Fink T, Tomkins-Tinch CH, Krasilnikova LA, DeRuff KC, Rudy M, Bauer MR, Lagerborg KA, Normandin E, Chapman SB, Reilly SK, Anahtar MN, Lin AE, Carter A, Myhrvold C, Kemball ME, Chaluvadi S, Cusick C, Flowers K, Neumann A, Cerrato F, Farhat M, Slater D, Harris JB, Branda J, Hooper D, Gaeta JM, Baggett TP, O'Connell J, Gnirke A, Lieberman TD, Philippakis A, Burns M, Brown CM, Luban J, Ryan ET, Turbett SE, LaRocque RC, Hanage WP, Gallagher GR, Madoff LC, Smole S, Pierce VM, Rosenberg E, Sabeti PC, Park DJ, Maclnnis BL.

medRxiv. 2020 Aug 25. PMID: 32869040


News

How to handle the next pandemic

Experts agree that it’s not “if” there will be another pandemic, but “when”—and that we should learn from our mistakes during the current one if we want to fare better next time.

What the U.S. did wrong with COVID-19

An article co-authored by Harvard Chan School researchers assessed federal missteps in responding to the COVID-19 pandemic that have led the U.S. to experience some of the most severe outcomes in the world.