Assistant Professor of Environmental Epigenetics
Ph.D., 2007, Harvard University
Finding the genome-environment balance
The relevance of environmental context to the expression of the genome is unequivocal. Environmental perturbations reshape biological networks, alter regulatory responses, and modulate the emergence of phenotypic variation and disease risk. Our laboratory pursues research themes in epigenetics that are inherently interdisciplinary: the long-term goal is to enhance genotype-phenotype maps.
In particular, three complementary sets of research themes are being pursued. One set is centered on Y-chromosome heterochromatin: its genetic and epigenetic variation, and manifold functional consequences. Another set of questions is centered on the systems biology of regulatory variation, epigenetic networks, and the dynamics of genotype-by-environmental interaction. A third set of questions addresses individual responses to the environment and the mechanisms through which environmental stress creates epi-alleles that are stable across generations.
We approach our research questions through careful genomic experimentation and integrative computational analyses. These are blended with rigorous genetic manipulations within meaningful environmental contexts. One area of interest has been on developing novel models to understand environmentally modulated human disease risk.
Branco AT, Hartl DL, Lemos B. 2013. Chromatin-associated proteins HP1 and Mod(mdg4) modify Y-linked regulatory variation in the Drosophila testis. Genetics 194(3):609-18
Reis AH, Vargas FR, Lemos B. 2012. More epigenetic hits than meets the eye: microRNAs and genes associated with the tumorigenesis of retinoblastoma. Frontiers in Genetics 3:284-
Sackton TB, Montenegro H, Hartl DL, Lemos B. 2011. Interspecific Y chromosome introgressions disrupt testis-specific gene expression and male reproductive phenotypes in Drosophila. Proceedings of the National Academy of Sciences 108(41):17046-17051.
Paredes S, Branco AT, Hartl DL, Maggert K, Lemos B. 2011. Ribosomal DNA deletions modulate genome-wide gene expression: “rDNA-sensitive” genes and natural variation. PLoS Genetics 7(4):e1001376.
Jiang PP, Hartl DL, Lemos B. 2010. Y not a dead end: Epistatic interactions between Y-linked regulatory polymorphisms and genetic background affect global gene expression in Drosophila melanogaster. Genetics 186:109-118.
Lemos B, Branco AT, Hartl DL. 2010. Epigenetic effects of polymorphic Y chromosomes modulate chromatin components, immune response, and sexual conflict. Proceedings of the National Academy of Sciences 107(36):15826-15831.
Lemos B, Araripe LO, Hartl DL. 2008. Polymorphic Y chromosomes harbor cryptic variation with manifold functional consequences. Science 319:91-93.
Lemos B. 2007. The opossum genome reveals further evidence for regulatory evolution in mammalian diversification. Genome Biology 8:223-226.
Landry¶ CR, Lemos¶ B, Rifkin SA, Dickinson WJ, Hartl DL. 2007. Genetic properties influencing the evolvability of gene expression. Science 317:118-121. ¶first two authors contributed equally