WELCOME AND INTRODUCTIONS

John B. Little, M.D.

Harvard School of Public Health

 Bruce Demple, Ph.D.

Harvard School of Public Health

John B. Little Award Lecture given by Dr. James E. Cleaver

University of California at San Francisco

“Xeroderma Pigmentosum – Cancer and Neurodegeneration; Prevention and Therapies”

DISCUSSION LEADER: Simon N. Powell, Ph.D.

Massachusetts General Hospital

Stephen Elledge, Ph.D.

Harvard Medical School

“Sensing and Responding to DNA Damage”

Sara A. Courtneidge, Ph.D.

Van Andel Research Institute

“The Roles of Src and its Substrate Fish in Tumorigenesis“

Nikki J. Holbrook, Ph.D.

Yale New Haven Hospital

“Factors Contributing to Declines in Stress Tolerance with Aging“

Ronald DePinho, M.D.

Dana-Farber Cancer Institute, Harvard Medical School

“Modeling Cancer and Cancer Genomes in the Mouse“

DISCUSSION LEADER: Andrew Grosovky, Ph.D.

University of California, Riverside

Leonard Guarente, Ph.D.

Massachusetts Institute of Technology

“SIR2 Longevity Gene as Mediator of Calorie Restriction in Yeast and Mammals“

Tomas A. Prolla, Ph.D.

University of Wisconsin

“The Gene Expression Profile Associated with the Aging Process”

Judith Campisi, Ph.D.

Lawrence Berkeley National Laboratory

“Cancer, Aging, and Protecting the Genome”  

Gary Ruvkun, Ph.D.

Massachusetts General Hospital

“Mitochondria and Metabolism Involvement in C. elegans Lifespan”

SESSION III: MECHANISMS OF GENETICS STABILITY

DISCUSSION LEADER: Amin I. Kassis, Ph.D.

Harvard Medical School 

Amato J. Giaccia, Ph.D.

Stanford University School of Medicine

“Regulation of Cell Differentiation by Hypoxia“

Samuel H. Wilson, M.D.

National Institutes of Health, National Institute of Environmental Health Sciences

“Multiple Roles of Base Excision Repair in Mammalian Cells”

Scott W. Lowe, Ph.D.

Cold Spring Harbor Laboratory

“Apoptosis and Senescence in Cancer Development and Therapy”