Publications

Publications from our core faculty laboratories:

Adaptive mutability of colorectal cancers in response to targeted therapies. Russo M, Crisafulli G, Sogari A, Reilly NM, Arena S, Lamba S, Bartolini A, Amodio V, Magrì A, Novara L, Sarotto I, Nagel ZD, Piett CG, Amatu A, Sartore-Bianchi A, Siena S, Bertotti A, Trusolino L, Corigliano M, Gherardi M, Lagomarsino MC, Di Nicolantonio F, Bardelli A. Science. 2019 Nov 7. pii: eaav4474. doi: 10.1126/science.aav4474. [Epub ahead of print]

Safer-by-design flame-sprayed silicon dioxide nanoparticles: the role of silanol content on ROS generation, surface activity and cytotoxicity. Rubio L, Pyrgiotakis G, Beltran-Huarac J, Zhang Y, Gaurav J, Deloid G, Spyrogianni A, Sarosiek KA, Bello D, Demokritou P. Part Fibre Toxicol. 2019 Oct 29;16(1):40. doi: 10.1186/s12989-019-0325-1.

Functional interplay between p53 and Δ133p53 in adaptive stress response. Gong L, Pan X, Abali GK, Little JB, Yuan ZM. Cell Death Differ. 2019 Oct 28. doi: 10.1038/s41418-019-0445-z. doi: 10.1038/s41418-019-0445-z. [Epub ahead of print]

Defective base excision repair in the response to DNA damaging agents in triple negative breast cancer. Lee KJ, Piett CG, Andrews JF, Mann E, Nagel ZD, Gassman NR. PLoS One. 2019 Oct 9;14(10):e0223725. doi: 10.1371/journal.pone.0223725. eCollection 2019.

Pooled Genomic Screens Identify Anti-apoptotic Genes as Targetable Mediators of Chemotherapy Resistance in Ovarian Cancer. Stover EH, Baco MB, Cohen O, Li YY, Christie EL, Bagul M, Goodale A, Lee Y, Pantel S, Rees MG, Wei G, Presser AG, Gelbard MK, Zhang W, Zervantonakis IK, Bhola PD, Ryan J, Guerriero JL, Montero J, Liang FJ, Cherniack AD, Piccioni F, Matulonis UA, Bowtell DDL, Sarosiek KA, Letai A, Garraway LA, Johannessen CM, Meyerson M. Mol Cancer Res. 2019 Nov;17(11):2281-2293. doi: 10.1158/1541-7786.MCR-18-1243. Epub 2019 Aug 28.

Epigenetic mechanisms behind cellular sensitivity to DNA damage. Williamson AK, Zhu Z, Yuan ZM. Cell Stress. 2018 Jun 12;2(7):176-180. doi: 10.15698/cst2018.07.145.

Sodium sulfide selectively induces oxidative stress, DNA damage, and mitochondrial dysfunction and radiosensitizes glioblastoma (GBM) cells. Xiao AY, Maynard MR, Piett CG, Nagel ZD, Alexander JS, Kevil CG, Berridge MV, Pattillo CB, Rosen LR, Miriyala S, Harrison L. Redox Biol. 2019 Sep;26:101220. doi: 10.1016/j.redox.2019.101220. Epub 2019 May 16.

Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents. Lossos C, Liu Y, Kolb KE, Christie AL, Van Scoyk A, Prakadan SM, Shigemori K, Stevenson KE, Morrow S, Plana OD, Fraser C, Jones KL, Liu H, Pallasch CP, Modiste R, Nguyen QD, Craig JW, Morgan EA, Vega F, Aster JC, Sarosiek KA, Shalek AK, Hemann MT, Weinstock DM. Cancer Discov. 2019 Jul;9(7):944-961. doi: 10.1158/2159-8290.CD-18-1393. Epub 2019 Apr 30.

WRN helicase is a synthetic lethal target in microsatellite unstable cancers. Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li T, Zhang Y, Bin Liu J, Lazaro JB, Gu P, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D’Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ. Nature. 2019 Apr;568(7753):551-556. doi: 10.1038/s41586-019-1102-x. Epub 2019 Apr 10.

Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells. Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD. PLoS One. 2019 Feb 27;14(2):e0208341. doi: 10.1371/journal.pone.0208341. eCollection 2019.

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Singh R, Letai A, Sarosiek K. Nat Rev Mol Cell Biol. 2019 Mar;20(3):175-193. doi: 10.1038/s41580-018-0089-8.

The CHD6 chromatin remodeler is an oxidative DNA damage response factor. Moore S, Berger ND, Luijsterburg MS, Piett CG, Stanley FKT, Schräder CU, Fang S, Chan JA, Schriemer DC, Nagel ZD, van Attikum H, Goodarzi AA. Nat Commun. 2019 Jan 16;10(1):241. doi: 10.1038/s41467-018-08111-y.

T Cells and Regulated Cell Death: Kill or Be Killed. Spetz J, Presser AG, Sarosiek KA. Int Rev Cell Mol Biol. 2019;342:27-71. doi: 10.1016/bs.ircmb.2018.07.004. Epub 2018 Aug 29.

BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies. Fraser C, Ryan J, Sarosiek K. Methods Mol Biol. 2019;1877:61-76. doi: 10.1007/978-1-4939-8861-7_4.

ZBTB7A governs estrogen receptor alpha expression in breast cancer. Molloy ME, Lewinska M, Williamson AK, Nguyen TT, Kuser-Abali G, Gong L, Yan J, Little JB, Pandolfi PP, Yuan ZM. J Mol Cell Biol. 2018 Aug 1;10(4):273-284. doi: 10.1093/jmcb/mjy020.

Exploiting MCL1 Dependency with Combination MEK + MCL1 Inhibitors Leads to Induction of Apoptosis and Tumor Regression in KRAS-Mutant Non-Small Cell Lung Cancer. Nangia V, Siddiqui FM, Caenepeel S, Timonina D, Bilton SJ, Phan N, Gomez-Caraballo M, Archibald HL, Li C, Fraser C, Rigas D, Vajda K, Ferris LA, Lanuti M, Wright CD, Raskin KA, Cahill DP, Shin JH, Keyes C, Sequist LV, Piotrowska Z, Farago AF, Azzoli CG, Gainor JF, Sarosiek KA, Brown SP, Coxon A, Benes CH, Hughes PE, Hata AN. Cancer Discov. 2018 Dec;8(12):1598-1613. doi: 10.1158/2159-8290.CD-18-0277. Epub 2018 Sep 25.

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG Jr. Cell. 2018 Sep 20;175(1):101-116.e25. doi: 10.1016/j.cell.2018.08.038. Epub 2018 Sep 13.

Nitric oxide induced S-nitrosation causes base excision repair imbalance. Parrish MC, Chaim IA, Nagel ZD, Tannenbaum SR, Samson LD, Engelward BP. DNA Repair (Amst). 2018 Aug;68:25-33. doi: 10.1016/j.dnarep.2018.04.008. Epub 2018 May 5.

Glycemic load is associated with diabetes and prediabetes among middle-aged and elderly adults in Guangzhou, China. He FY, Chen CG, Lin DZ, Li F, Lin XH, Yuan ZM, Yan L. Asia Pac J Clin Nutr. 2018;27(3):655-661. doi: 10.6133/apjcn.042017.05.

ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade. Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G. Nat Med. 2018 May;24(5):556-562. doi: 10.1038/s41591-018-0012-z. Epub 2018 May 7.

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment. Spetz J, Moslehi J, Sarosiek K. Curr Treat Options Cardiovasc Med. 2018 Mar 20;20(4):31. doi: 10.1007/s11936-018-0627-x.
An EZH2-mediated epigenetic mechanism behind p53-dependent tissue sensitivity to DNA damage. Kuser-Abali G, Gong L, Yan J, Liu Q, Zeng W, Williamson A, Lim CB, Molloy ME, Little JB, Huang L, Yuan ZM. Proc Natl Acad Sci U S A. 2018 Mar 27;115(13):3452-3457. doi: 10.1073/pnas.1719532115. Epub 2018 Mar 14.

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Gutierrez-Martinez P, Hogdal L, Nagai M, Kruta M, Singh R, Sarosiek K, Nussenzweig A, Beerman I, Letai A, Rossi DJ. Nat Cell Biol. 2018 Apr;20(4):413-421. doi: 10.1038/s41556-018-0054-y. Epub 2018 Mar 12.

A functional interplay between Δ133p53 and ΔNp63 in promoting glycolytic metabolism to fuel cancer cell proliferation. Gong L, Pan X, Lim CB, de Polo A, Little JB, Yuan ZM. Oncogene. 2018 Apr;37(16):2150-2164. doi: 10.1038/s41388-017-0117-8. Epub 2018 Jan 26.

In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities. Chaim IA, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10379-E10388. doi: 10.1073/pnas.1712032114. Epub 2017 Nov 9.

BCL-X(L) directly modulates RAS signalling to favour cancer cell stemness. Carné Trécesson S, Souazé F, Basseville A, Bernard AC, Pécot J, Lopez J, Bessou M, Sarosiek KA, Letai A, Barillé-Nion S, Valo I, Coqueret O, Guette C, Campone M, Gautier F, Juin PP. Nat Commun. 2017 Oct 24;8(1):1123. doi: 10.1038/s41467-017-01079-1.

Epigenetics make transient states of cancer therapy resistance permanent. Sarosiek K. Sci Transl Med. 2017 Jun 28;9(396). pii: eaan6729. doi: 10.1126/scitranslmed.aan6729.

Chemotherapy-treated cells go up in flames. Sarosiek K. Sci Transl Med. 2017 May 17;9(390). pii: eaan4289. doi: 10.1126/scitranslmed.aan4289.

Towards precision prevention: Technologies for identifying healthy individuals with high risk of disease. Nagel ZD, Engelward BP, Brenner DJ, Begley TJ, Sobol RW, Bielas JH, Stambrook PJ, Wei Q, Hu JJ, Terry MB, Dilworth C, McAllister KA, Reinlib L, Worth L, Shaughnessy DT. Mutat Res. 2017 Aug;800-802:14-28. doi: 10.1016/j.mrfmmm.2017.03.007. Epub 2017 Apr 6.

Double trouble for CML. Sarosiek K. Sci Transl Med. 2017 Apr 5;9(384). pii: e2773. doi: 10.1126/scitranslmed.aan2773.

Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis. Gunda V, Sarosiek KA, Brauner E, Kim YS, Amin S, Zhou Z, Letai A, Parangi S. Cancer Lett. 2017 Jun 1;395:1-10. doi: 10.1016/j.canlet.2017.02.028. Epub 2017 Mar 1.

Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics. Sarosiek KA, Fraser C, Muthalagu N, Bhola PD, Chang W, McBrayer SK, Cantlon A, Fisch S, Golomb-Mello G, Ryan JA, Deng J, Jian B, Corbett C, Goldenberg M, Madsen JR, Liao R, Walsh D, Sedivy J, Murphy DJ, Carrasco DR, Robinson S, Moslehi J, Letai A. Cancer Cell. 2017 Jan 9;31(1):142-156. doi: 10.1016/j.ccell.2016.11.011. Epub 2016 Dec 22.

Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance. Pécot J, Maillet L, Le Pen J, Vuillier C, Trécesson SC, Fétiveau A, Sarosiek KA, Bock FJ, Braun F, Letai A, Tait SWG, Gautier F, Juin PP. Cell Rep. 2016 Dec 20;17(12):3347-3358. doi: 10.1016/j.celrep.2016.11.064.

AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM. J Mol Cell Biol. 2017 Apr 1;9(2):154-165. doi: 10.1093/jmcb/mjw045.

MDMX under stress: the MDMX-MDM2 complex as stress signals hub. de Polo A, Vivekanandan V, Little JB, Yuan ZM. Transl Cancer Res. 2016 Dec;5(6):725-732. doi: 10.21037/tcr.2016.12.18.

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer. Johnson SF, Cruz C, Greifenberg AK, Dust S, Stover DG, Chi D, Primack B, Cao S, Bernhardy AJ, Coulson R, Lazaro JB, Kochupurakkal B, Sun H, Unitt C, Moreau LA, Sarosiek KA, Scaltriti M, Juric D, Baselga J, Richardson AL, Rodig SJ, D’Andrea AD, Balmaña J, Johnson N, Geyer M, Serra V, Lim E, Shapiro GI. Cell Rep. 2016 Nov 22;17(9):2367-2381. doi: 10.1016/j.celrep.2016.10.077.

DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme. Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD. Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151. Epub 2016 Oct 28.

Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. Gerarduzzi C, de Polo A, Liu XS, El Kharbili M, Little JB, Yuan ZM. J Biol Chem. 2016 Dec 9;291(50):25937-25949. doi: 10.1074/jbc.M116.752303. Epub 2016 Oct 24.

Musashi1 Impacts Radio-Resistance in Glioblastoma by Controlling DNA-Protein Kinase Catalytic Subunit. de Araujo PR, Gorthi A, da Silva AE, Tonapi SS, Vo DT, Burns SC, Qiao M, Uren PJ, Yuan ZM, Bishop AJ, Penalva LO. Am J Pathol. 2016 Sep;186(9):2271-8. doi: 10.1016/j.ajpath.2016.05.020. Epub 2016 Jul 25.

Interleukin 21 – its potential role in the therapy of B-cell lymphomas. Bhatt S, Sarosiek KA, Lossos IS. Leuk Lymphoma. 2017 Jan;58(1):17-29. doi: 10.1080/10428194.2016.1201568. Epub 2016 Jul 13.

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition. Burger JA, Landau DA, Taylor-Weiner A, Bozic I, Zhang H, Sarosiek K, Wang L, Stewart C, Fan J, Hoellenriegel J, Sivina M, Dubuc AM, Fraser C, Han Y, Li S, Livak KJ, Zou L, Wan Y, Konoplev S, Sougnez C, Brown JR, Abruzzo LV, Carter SL, Keating MJ, Davids MS, Wierda WG, Cibulskis K, Zenz T, Werner L, Dal Cin P, Kharchencko P, Neuberg D, Kantarjian H, Lander E, Gabriel S, O’Brien S, Letai A, Weitz DA, Nowak MA, Getz G, Wu CJ. Nat Commun. 2016 May 20;7:11589. doi: 10.1038/ncomms11589.

Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response. Beharry AA, Nagel ZD, Samson LD, Kool ET. PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684. eCollection 2016.

Directly targeting the mitochondrial pathway of apoptosis for cancer therapy using BH3 mimetics – recent successes, current challenges and future promise. Sarosiek KA, Letai A. FEBS J. 2016 Oct;283(19):3523-3533. doi: 10.1111/febs.13714.

Uranium biosorption from aqueous solution onto Eichhornia crassipes. Yi ZJ, Yao J, Chen HL, Wang F, Yuan ZM, Liu X. J Environ Radioact. 2016 Apr;154:43-51. doi: 10.1016/j.jenvrad.2016.01.012. Epub 2016 Feb 6.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, et al. Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.

p53 coordinates with Δ133p53 isoform to promote cell survival under low-level oxidative stress. Gong L, Pan X, Yuan ZM, Peng J, Chen J. J Mol Cell Biol. 2016 Feb;8(1):88-90. doi: 10.1093/jmcb/mjv069. Epub 2015 Dec 23.

p53-based strategy to reduce hematological toxicity of chemotherapy: A proof of principle study. Ha CS, Michalek JE, Elledge R, Kelly KR, Ganapathy S, Su H, Jenkins CA, Argiris A, Swords R, Eng TY, Karnad A, Crownover RL, Swanson GP, Goros M, Pollock BH, Yuan ZM. Mol Oncol. 2016 Jan;10(1):148-56. doi: 10.1016/j.molonc.2015.09.004. Epub 2015 Sep 18.

Removal of Pb(II) by adsorption onto Chinese walnut shell activated carbon. Yi ZJ, Yao J, Kuang YF, Chen HL, Wang F, Yuan ZM. Water Sci Technol. 2015;72(6):983-9. doi: 10.2166/wst.2015.305.

Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma. Bhatt S, Matthews J, Parvin S, Sarosiek KA, Zhao D, Jiang X, Isik E, Letai A, Lossos IS. Blood. 2015 Sep 24;126(13):1555-64. doi: 10.1182/blood-2015-01-624585. Epub 2015 Jul 20.

CRISPR-Cas9 systems: versatile cancer modelling platforms and promising therapeutic strategies. Wen WS, Yuan ZM, Ma SJ, Xu J, Yuan DT. Int J Cancer. 2016 Mar 15;138(6):1328-36. doi: 10.1002/ijc.29626. Epub 2015 Jun 19.

p53-Based Strategy for Protection of Bone Marrow From Y-90 Ibritumomab Tiuxetan. Su H, Ganapathy S, Li X, Yuan ZM, Ha CS. Int J Radiat Oncol Biol Phys. 2015 Aug 1;92(5):1116-1122. doi: 10.1016/j.ijrobp.2015.04.003. Epub 2015 Apr 8.

Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide. McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD. Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.

ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. Mol Cancer Res. 2015 Aug;13(8):1206-17. doi: 10.1158/1541-7786.MCR-15-0169. Epub 2015 May 20.

UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity. Qi M, Ganapathy S, Zeng W, Zhang J, Little JB, Yuan ZM. Oncotarget. 2015 Jul 10;6(19):17584-93. doi: 10.18632/oncotarget.3770.

Glycolytic metabolism influences global chromatin structure. Liu XS, Little JB, Yuan ZM. Oncotarget. 2015 Feb 28;6(6):4214-25. doi: 10.18632/oncotarget.2929.

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy. Montero J, Sarosiek KA, DeAngelo JD, Maertens O, Ryan J, Ercan D, Piao H, Horowitz NS, Berkowitz RS, Matulonis U, Jänne PA, Amrein PC, Cichowski K, Drapkin R, Letai A. Cell. 2015 Feb 26;160(5):977-989. doi: 10.1016/j.cell.2015.01.042.

RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis. Winter PS, Sarosiek KA, Lin KH, Meggendorfer M, Schnittger S, Letai A, Wood KC. Sci Signal. 2014 Dec 23;7(357):ra122. doi: 10.1126/scisignal.2005301.

ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. Genes Dev. 2014 Sep 1;28(17):1917-28. doi: 10.1101/gad.245910.114.

A phosphotyrosine switch determines the antitumor activity of ERβ. Yuan B, Cheng L, Chiang HC, Xu X, Han Y, Su H, Wang L, Zhang B, Lin J, Li X, Xie X, Wang T, Tekmal RR, Curiel TJ, Yuan ZM, Elledge R, Hu Y, Ye Q, Li R. J Clin Invest. 2014 Aug;124(8):3378-90. doi: 10.1172/JCI74085. Epub 2014 Jun 24.

Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research. Nagel ZD, Chaim IA, Samson LD. DNA Repair (Amst). 2014 Jul;19:199-213. doi: 10.1016/j.dnarep.2014.03.009. Epub 2014 Apr 26.

Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis. Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD. Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111. Epub 2014 Apr 22.

Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. Hata AN, Yeo A, Faber AC, Lifshits E, Chen Z, Cheng KA, Walton Z, Sarosiek KA, Letai A, Heist RS, Mino-Kenudson M, Wong KK, Engelman JA. Cancer Res. 2014 Jun 1;74(11):3146-56. doi: 10.1158/0008-5472.CAN-13-3728. Epub 2014 Mar 27.

A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. J Biol Chem. 2014 Feb 21;289(8):5340-7. doi: 10.1074/jbc.M113.531020. Epub 2014 Jan 3.

Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance. Johnson N, Johnson SF, Yao W, Li YC, Choi YE, Bernhardy AJ, Wang Y, Capelletti M, Sarosiek KA, Moreau LA, Chowdhury D, Wickramanayake A, Harrell MI, Liu JF, D’Andrea AD, Miron A, Swisher EM, Shapiro GI. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17041-6. doi: 10.1073/pnas.1305170110. Epub 2013 Oct 1.

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response. Sarosiek KA, Chi X, Bachman JA, Sims JJ, Montero J, Patel L, Flanagan A, Andrews DW, Sorger P, Letai A. Mol Cell. 2013 Sep 26;51(6):751-65. doi: 10.1016/j.molcel.2013.08.048.

Mitochondria: gatekeepers of response to chemotherapy. Sarosiek KA, Ni Chonghaile T, Letai A. Trends Cell Biol. 2013 Dec;23(12):612-9. doi: 10.1016/j.tcb.2013.08.003. Epub 2013 Sep 21.

Identification of a long-range protein network that modulates active site dynamics in extremophilic alcohol dehydrogenases. Nagel ZD, Cun S, Klinman JP. J Biol Chem. 2013 May 17;288(20):14087-97. doi: 10.1074/jbc.M113.453951. Epub 2013 Mar 22.

MDM2 and MDMX: Alone and together in regulation of p53. Shadfan M, Lopez-Pajares V, Yuan ZM. Transl Cancer Res. 2012 Aug;1(2):88-89.

Guidelines for the use and interpretation of assays for monitoring autophagy. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC Jr, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, et al. Autophagy. 2012 Apr;8(4):445-544. doi: 10.4161/auto.19496.

Active site hydrophobic residues impact hydrogen tunneling differently in a thermophilic alcohol dehydrogenase at optimal versus nonoptimal temperatures. Nagel ZD, Meadows CW, Dong M, Bahnson BJ, Klinman JP. Biochemistry. 2012 May 22;51(20):4147-56. doi: 10.1021/bi3001352. Epub 2012 May 8.

Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy. Ni Chonghaile T, Sarosiek KA, Vo TT, Ryan JA, Tammareddi A, Moore Vdel G, Deng J, Anderson KC, Richardson P, Tai YT, Mitsiades CS, Matulonis UA, Drapkin R, Stone R, Deangelo DJ, McConkey DJ, Sallan SE, Silverman L, Hirsch MS, Carrasco DR, Letai A. Science. 2011 Nov 25;334(6059):1129-33. doi: 10.1126/science.1206727. Epub 2011 Oct 27.

Modulation of autophagic activity by extracellular pH. Xu T, Su H, Ganapathy S, Yuan ZM. Autophagy. 2011 Nov;7(11):1316-22. doi: 10.4161/auto.7.11.17785. Epub 2011 Nov 1.

The p53 inhibitors MDM2/MDMX complex is required for control of p53 activity in vivo. Huang L, Yan Z, Liao X, Li Y, Yang J, Wang ZG, Zuo Y, Kawai H, Shadfan M, Ganapathy S, Yuan ZM. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12001-6. doi: 10.1073/pnas.1102309108. Epub 2011 Jul 5.

Impaired protein conformational landscapes as revealed in anomalous Arrhenius prefactors. Nagel ZD, Dong M, Bahnson BJ, Klinman JP. Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10520-5. doi: 10.1073/pnas.1104989108. Epub 2011 Jun 13.

Inhibition of p53 DNA binding function by the MDM2 protein acidic domain. Cross B, Chen L, Cheng Q, Li B, Yuan ZM, Chen J. J Biol Chem. 2011 May 6;286(18):16018-29. doi: 10.1074/jbc.M111.228981. Epub 2011 Mar 17.

Update 1 of: Tunneling and dynamics in enzymatic hydride transfer. Nagel ZD, Klinman JP. Chem Rev. 2010 Dec 8;110(12):PR41-67. doi: 10.1021/cr1001035.

HGAL, a germinal center specific protein, decreases lymphoma cell motility by modulation of the RhoA signaling pathway. Jiang X, Lu X, McNamara G, Liu X, Cubedo E, Sarosiek KA, Sánchez-García I, Helfman DM, Lossos IS. Blood. 2010 Dec 9;116(24):5217-27. doi: 10.1182/blood-2010-04-281568. Epub 2010 Sep 15.

Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma. Sarosiek KA, Cavallin LE, Bhatt S, Toomey NL, Natkunam Y, Blasini W, Gentles AJ, Ramos JC, Mesri EA, Lossos IS. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13069-74. doi: 10.1073/pnas.1002985107. Epub 2010 Jul 6.

MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output. Chen L, Li Z, Zwolinska AK, Smith MA, Cross B, Koomen J, Yuan ZM, Jenuwein T, Marine JC, Wright KL, Chen J. EMBO J. 2010 Aug 4;29(15):2538-52. doi: 10.1038/emboj.2010.140. Epub 2010 Jun 29.

Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Sarosiek KA, Malumbres R, Nechushtan H, Gentles AJ, Avisar E, Lossos IS. Blood. 2010 Jan 21;115(3):570-80. doi: 10.1182/blood-2009-08-239996. Epub 2009 Nov 20.

Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM. Radiat Res. 2009 Sep;172(3):306-13. doi: 10.1667/RR1764.1.

Interleukin-4 distinctively modifies responses of germinal centre-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy. Sarosiek KA, Nechushtan H, Lu X, Rosenblatt JD, Lossos IS. Br J Haematol. 2009 Nov;147(3):308-18. doi: 10.1111/j.1365-2141.2009.07851.x. Epub 2009 Aug 19.

A 21st century revisionist’s view at a turning point in enzymology. Nagel ZD, Klinman JP. Nat Chem Biol. 2009 Aug;5(8):543-50. doi: 10.1038/nchembio.204.

Multiple synostoses syndrome is due to a missense mutation in exon 2 of FGF9 gene. Wu XL, Gu MM, Huang L, Liu XS, Zhang HX, Ding XY, Xu JQ, Cui B, Wang L, Lu SY, Chen XY, Zhang HG, Huang W, Yuan WT, Yang JM, Gu Q, Fei J, Chen Z, Yuan ZM, Wang ZG. Am J Hum Genet. 2009 Jul;85(1):53-63. doi: 10.1016/j.ajhg.2009.06.007.

Stochastic modeling and simulation of the p53-MDM2/MDMX loop. Cai X, Yuan ZM. J Comput Biol. 2009 Jul;16(7):917-33. doi: 10.1089/cmb.2008.0231.

Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Malumbres R, Sarosiek KA, Cubedo E, Ruiz JW, Jiang X, Gascoyne RD, Tibshirani R, Lossos IS. Blood. 2009 Apr 16;113(16):3754-64. doi: 10.1182/blood-2008-10-184077. Epub 2008 Dec 1.

Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Cancer Res. 2008 Nov 15;68(22):9131-6. doi: 10.1158/0008-5472.CAN-08-3025.

PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. Lu X, Malumbres R, Shields B, Jiang X, Sarosiek KA, Natkunam Y, Tiganis T, Lossos IS. Blood. 2008 Nov 15;112(10):4098-108. doi: 10.1182/blood-2008-03-148726. Epub 2008 Aug 20.

S-state dependence of the calcium requirement and binding characteristics in the oxygen-evolving complex of photosystem II. Miqyass M, Marosvölgyi MA, Nagel Z, Yocum CF, van Gorkom HJ. Biochemistry. 2008 Jul 29;47(30):7915-24. doi: 10.1021/bi8006059. Epub 2008 Jul 2.

Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. Lopez-Pajares V, Kim MM, Yuan ZM. J Biol Chem. 2008 May 16;283(20):13707-13. doi: 10.1074/jbc.M710030200. Epub 2008 Mar 20.

RING domain-mediated interaction is a requirement for MDM2’s E3 ligase activity. Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan ZM. Cancer Res. 2007 Jul 1;67(13):6026-30. doi: 10.1158/0008-5472.CAN-07-1313.

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6. Lu X, Chen J, Sasmono RT, Hsi ED, Sarosiek KA, Tiganis T, Lossos IS. Mol Cell Biol. 2007 Mar;27(6):2166-79. doi: 10.1128/MCB.01234-06. Epub 2007 Jan 8.

Functional inactivation of P53 as a potential mechanism of MLL leukemogenesis. Wiederschain D, Yuan ZM. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct;31(5):617-20.

c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. Stuart JR, Gonzalez FH, Kawai H, Yuan ZM. J Biol Chem. 2006 Oct 20;281(42):31290-7. doi: 10.1074/jbc.M602389200. Epub 2006 Aug 9.

Tunneling and dynamics in enzymatic hydride transfer. Nagel ZD, Klinman JP. Chem Rev. 2006 Aug;106(8):3095-118. doi: 10.1021/cr050301x.

c-Abl regulates early growth response protein (EGR1) in response to oxidative stress. Stuart JR, Kawai H, Tsai KK, Chuang EY, Yuan ZM. Oncogene. 2005 Dec 8;24(55):8085-92. doi: 10.1038/sj.onc.1208953.

Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Tsai KK, Chuang EY, Little JB, Yuan ZM. Cancer Res. 2005 Aug 1;65(15):6734-44. doi: 10.1158/0008-5472.CAN-05-0703.

Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. Wiederschain D, Kawai H, Shilatifard A, Yuan ZM. J Biol Chem. 2005 Jul 1;280(26):24315-21. doi: 10.1074/jbc.M412237200. Epub 2005 Apr 25.

Transcription-independent suppression of DNA synthesis by p53 in sperm-irradiated mouse zygotes. Toyoshima M, Shimura T, Adiga SK, Taga M, Shiraishi K, Inoue M, Yuan ZM, Niwa O. Oncogene. 2005 May 5;24(20):3229-35. doi: 10.1038/sj.onc.1208514.

Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S. Nat Genet. 2004 Jan;36(1):55-62. doi: 10.1038/ng1279. Epub 2003 Dec 14.

DNA damage-induced MDMX degradation is mediated by MDM2. Kawai H, Wiederschain D, Kitao H, Stuart J, Tsai KK, Yuan ZM. J Biol Chem. 2003 Nov 14;278(46):45946-53. doi: 10.1074/jbc.M308295200. Epub 2003 Sep 8.

Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Kawai H, Wiederschain D, Yuan ZM. Mol Cell Biol. 2003 Jul;23(14):4939-47. doi: 10.1128/mcb.23.14.4939-4947.2003.

c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Tsai KK, Yuan ZM. Cancer Res. 2003 Jun 15;63(12):3418-24.

Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM. Mol Cell Biol. 2003 Jun;23(12):4230-46. doi: 10.1128/mcb.23.12.4230-4246.2003.

Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. Kitao H, Yuan ZM. J Biol Chem. 2002 Dec 13;277(50):48944-8. doi: 10.1074/jbc.M208151200. Epub 2002 Oct 11.

Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Kawai H, Nie L, Yuan ZM. Mol Cell Biol. 2002 Sep;22(17):6079-88. doi: 10.1128/mcb.22.17.6079-6088.2002.

Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. J Biol Chem. 2002 May 31;277(22):19251-4. doi: 10.1074/jbc.C200150200. Epub 2002 Apr 12.

p53-dependent S-phase damage checkpoint and pronuclear cross talk in mouse zygotes with X-irradiated sperm. Shimura T, Inoue M, Taga M, Shiraishi K, Uematsu N, Takei N, Yuan ZM, Shinohara T, Niwa O. Mol Cell Biol. 2002 Apr;22(7):2220-8. doi: 10.1128/mcb.22.7.2220-2228.2002.