Associate Professor of Medicine, Harvard Medical School
Co-Director, Epidemiology and Genetics Core, Boston Nutrition Obesity Research Center
M.D., National University of Colombia
Sc.M. (Epidemiology), Harvard School of Public Health
Sc.D. (Nutrition and Epidemiology), Harvard School of Public Health
My research focuses on investigating the role of nutritional factors in the pathogenesis of diseases affecting reproductive and hormone sensitive organs currently focusing on two main areas.
First, I am investigating the role of diet on human fertility. I use data from population-based cohorts and from studies of couples undergoing treatment for infertility to analyze the relationship between dietary factors and female reproductive potential at multiple points (ovulation, early embryonic development, implantation, early embryonic survival) as well as with conditions associated with infertility (e.g. ovulation disorders, endometriosis). In addition, I am currently investigating how different dietary factors are related to semen quality parameters and other biomarkers of male fertility in both clinical and population-based studies. The overarching goal of these projects is to identify modifiable lifestyle factors associated with fertility in humans and to estimate the burden of infertility attributable to them.
Another area of research is the investigation of nutritional and metabolic factors in the development and progression of prostate cancer. Using data from ongoing cohort studies, I study the relationships of dietary fatty acid intakes and biomarkers of fatty acid intake and metabolism with prostate cancer risk and survival.
In addition to these research areas, I am currently leading an effort to establish an internet-based cohort of young health professional women (www.nhs3.org). This study will evaluate the role of diet, lifestyle and biological factors on various aspects of women’s health including a strong emphasis on reproductive outcomes in the early years of the cohort. Ultimately, the goal of this study is to build a resource that can allow the investigation of how lifestyle factors during adolescence and early adulthood contribute to the etiology of chronic diseases later in life.
Selected Professional Affiliations
Society for Epidemiologic Research
American Society for Reproductive Medicine
American Association for Cancer Research