Experimental Ebola vaccine found highly effective in trial

An experimental Ebola vaccine tested in a trial of more than 4,000 people in Guinea has shown a high level of effectiveness, according a new study in The Lancet.

In the trial, experts used a “ring vaccination” strategy—the same strategy used to help eradicate smallpox—which involved inoculating clusters of adults who had come into contact with Ebola patients, and contacts around those contacts, such as neighbors, classmates, or extended family. Some of the clusters inoculated were whole villages, some were sections of towns or cities. In each experimental cluster, some people were vaccinated immediately, while others were vaccinated after 21 days, the maximum incubation period for the Ebola virus.

Researchers found that, in those inoculated immediately (4,123 people), there were no new cases of Ebola at least 10 days afterwards. Among those inoculated after 21 days (3,528 people), there were 16 cases of Ebola. Including all the adults in the study, researchers estimated that the vaccine was more than 75% effective.

The clinical trial in Guinea “has been more successful than we almost could have hoped for,” said one of the study’s senior authors, John-Arne Rottingen, adjunct professor of global health and population at Harvard T. H. Chan School of Public Health and head of infectious disease control at the Norwegian Institute of Public Health, in a July 31, 2015 New York Times article.

A large team including scientists, physicians, epidemiologists and experts from the World Health Organization, Norway, Canada, Guinea, Doctors Without Borders, Universities of Florida, Maryland and Bern, and the London School of Hygiene & Tropical Medicine were also involved in the study, in which a vaccine was developed and brought to clinical trial in just 12 months—record time for a vaccine trial, which usually take years.

Read the New York Times article: Experimental Ebola Vaccine Tested in Guinea Shows Promise, Report Says

Read a press release about the study: New Vaccine is Effective against Ebola in Large Trial in Guinea

Read The Lancet study: Efficacy and effectiveness of an rVSV-vectored vaccine expressing Ebola surface glycoprotein: interim results from the Guinea ring vaccination cluster-randomised trial

Learn more

Ebola in the news (Harvard Chan School news)