Wildfire smoke may have contributed to thousands of extra COVID-19 cases and deaths in western U.S. in 2020

California wildfires

For immediate release: Friday, August 13, 2021

Boston, MA – Thousands of COVID-19 cases and deaths in California, Oregon, and Washington between March and December 2020 may be attributable to increases in fine particulate air pollution (PM2.5) from wildfire smoke, according to a new study co-authored by researchers at Harvard T.H. Chan School of Public Health.

The study is the first to quantify the degree to which increases in PM2.5 pollution during the wildfires contributed to excess COVID-19 cases and deaths in the U.S. It was  published online August 13, 2021, in Science Advances.

“The year 2020 brought unimaginable challenges in public health, with the convergence of the COVID-19 pandemic and wildfires across the western United States. In this study we are providing evidence that climate change—which increases the frequency and the intensity of wildfires—and the pandemic are a disastrous combination,” said Francesca Dominici, Clarence James Gamble Professor of Biostatistics, Population and Data Science at Harvard Chan School and senior author of the study.

In 2020, at the same time the nation was contending with the COVID-19 pandemic, huge wildfires swept across the western U.S., including some of the largest ever in California and Washington. Wildfires produce high levels of fine particulate matter (PM2.5), which has been linked with a host of negative health outcomes, including premature death, asthma, chronic obstructive pulmonary diseases (COPD), and other respiratory illnesses. In addition, recent studies have found a link between short- and long-term exposure to PM2.5 and COVID-19 cases and deaths.

The researchers—from Harvard Chan School, the John A. Paulson School of Engineering and Applied Sciences at Harvard University, and the Environmental Systems Research Institute in Redlands, Calif.—built and validated a statistical model to quantify the extent to which wildfire smoke may have contributed to excess COVID-19 cases and deaths in California, Oregon, and Washington, three states that bore the brunt of the 2020 wildfires. They looked at the connection between county- and daily-level data on PM2.5 air concentrations from monitoring data, wildfire days from satellite data, and the number of COVID-19 cases and deaths in 92 counties, which represented 95% of the population across the three states. The researchers accounted for factors such as weather, population size, and societal patterns of social distancing and mass gatherings.

The study found that from August 15 to October 15, 2020, when fire activity was greatest, daily levels of PM2.5 during wildfire days were significantly higher than on non-wildfire days, with a median of 31.2 micrograms per cubic meter of air (µg/m3) versus 6.4 (µg/m3). In some counties, the levels of PM2.5 on wildfire days reached extremely high levels. For instance, from September 14 to September 17, 2020, Mono County, Calif., experienced four days in a row with PM2.5 levels higher than 500 µg/m3 as a result of the Creek Fire. Such levels are deemed “hazardous” by the U.S. Environmental Protection Agency.

Wildfires amplified the effect of exposure to PM2.5 on COVID-19 cases and deaths, up to four weeks after the exposure, the study found. In some counties, the percentage of the total number of COVID-19 cases and deaths attributable to high PM2.5 levels was substantial.

On average across all counties, the study found that a daily increase of 10 µg/m3 in PM2.5 each day for 28 subsequent days was associated with an 11.7% increase in COVID-19 cases, and an 8.4% increase in COVID-19 deaths. The biggest effects for the COVID-19 cases were in the counties of Sonoma, Calif., and Whitman, Wash., with a 65.3% and 71.6% increase, respectively. The biggest effects for the COVID-19 deaths were in Calaveras, Calif., and San Bernardino, Calif., with a 52.8% and 65.9% increase, respectively.

Researchers also looked at individual wildfire days and at individual counties to determine the percentage increase in COVID-19 cases and deaths in 2020 compared with what would have been expected with lower levels of PM2.5. They found that Butte, Calif. and Whitman, Wash. had the highest percentage increases in cases (17.3% and 18.2%, respectively); and that Butte, Calif. and Calaveras, Calif. had the highest percentage increases in deaths (41% and 137.4%, respectively.) In Calaveras, roughly nine COVID-19 deaths would have been expected under lower PM2.5 levels, but the actual number was 22—which explains the high percentage increase.

Across the three states studied, the cumulative number of COVID-19 cases and deaths attributable to daily increases in PM2.5 from wildfires was, respectively, 19,700 and 750, the study found.

“Climate change will likely bring warmer and drier conditions to the West, providing more fuel for fires to consume and further enhancing fire activity. This study provides policymakers with key information regarding how the effects of one global crisis—climate change—can have cascading effects on concurrent global crises—in this case, the COVID-19 pandemic,” said Dominici.

Co-first authors of the study were Xiaodan Zhou of the Environmental Systems Research Institute and Kevin Josey from the Department of Biostatistics at Harvard Chan School. Leila Kamareddine of the Department of Biostatistics at Harvard Chan School also contributed, as did Miah C. Caine and Loretta J. Mickley from Harvard’s John A. Paulson School of Engineering and Applied Sciences, and Tianjia Liu from Harvard’s Department of Earth and Planetary Sciences.

Funding for the study came from the Environmental Protection Agency (grant 83587201-0), the National Institutes of Health (grants R01ES026217, R01MD012769, R01ES028033, 1R01AG060232-01A1, 1R01ES030616, 1R01AG066793-01R01, 1R01ES029950, and 5T32ES007142), the Alfred P. Sloan Foundation, and the Vice Provost for Research-Harvard University.

“Excess of COVID-19 Cases and Deaths due to Fine Particulate Matter Exposure During the 2020 Wildfires in the United States,” Xiaodan Zhou, Kevin Josey, Leila Kamareddine, Miah C. Caine, Tianjia Liu, Loretta J. Mickley, Matthew Cooper, and Francesca Dominici, Science Advances, online August 13, 2021, doi: 10.1126/sciadv.abi8789.

Photo: Brody Hessin/Wikimedia

*This release was updated on August 20, 2021.

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Harvard T.H. Chan School of Public Health brings together dedicated experts from many disciplines to educate new generations of global health leaders and produce powerful ideas that improve the lives and health of people everywhere. As a community of leading scientists, educators, and students, we work together to take innovative ideas from the laboratory to people’s lives—not only making scientific breakthroughs, but also working to change individual behaviors, public policies, and health care practices. Each year, more than 400 faculty members at Harvard Chan School teach 1,000-plus full-time students from around the world and train thousands more through online and executive education courses. Founded in 1913 as the Harvard-MIT School of Health Officers, the School is recognized as America’s oldest professional training program in public health.