Fine-mapping causal tissues and genes at disease-associated loci.
Strober BJ, Zhang MJ, Amariuta T, Rossen J, Price AL.
medRxiv. 2024 Jun 17. PMID: 37961337
Overview
I am a professor in the Program in Genetic Epidemiology and Statistical Genetics in the Department of Epidemiology at HSPH, with a secondary appointment in the Department of Biostatistics. I am an associate member of the Program in Medical and Population Genetics at the Broad Institute, and a member of the Program in Quantitative Genomics at HSPH. I am the recipient of the 2017 Harvard Chan Outstanding Postdoctoral Mentor Award. Our research focuses on the development of statistical methods for uncovering the genetic basis of human disease, and on the population genetics underlying these methods. Areas of interest include functional components of heritability, common vs. rare variant architectures, and disease mapping in structured populations.
[b]"Everything should be made as simple as possible, but no simpler" - Albert Einstein[/b]
Bibliography
Linking regulatory variants to target genes by integrating single-cell multiome methods and genomic distance.
Dorans E, Jagadeesh K, Dey K, Price AL.
medRxiv. 2024 May 25. PMID: 38826240
Genome-wide association studies in a large Korean cohort identify novel quantitative trait loci for 36 traits and illuminates their genetic architectures.
Jee YH, Wang Y, Jung KJ, Lee JY, Kimm H, Duan R, Price AL, Martin AR, Kraft P.
medRxiv. 2024 May 18. PMID: 38798434
MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data.
Rossen J, Shi H, Strober BJ, Zhang MJ, Kanai M, McCaw ZR, Liang L, Weissbrod O, Price AL.
medRxiv. 2024 May 13. PMID: 38798542
Distinct explanations underlie gene-environment interactions in the UK Biobank.
Durvasula A, Price AL.
medRxiv. 2024 Apr 18. PMID: 37790574
Tissue-specific enhancer-gene maps from multimodal single-cell data identify causal disease alleles.
Sakaue S, Weinand K, Isaac S, Dey KK, Jagadeesh K, Kanai M, Watts GFM, Zhu Z, Brenner MB, McDavid A, Donlin LT, Wei K, Price AL, Raychaudhuri S.
Nat Genet. 2024 Apr. 56(4):615-626. PMID: 38594305
Distinguishing different psychiatric disorders using DDx-PRS.
Peyrot WJ, Panagiotaropoulou G, Olde Loohuis LM, Adams MJ, Awasthi S, Ge T, McIntosh AM, Mitchell BL, Mullins N, O'Connell KS, Penninx BWJH, Posthuma D, Ripke S, Ruderfer DM, Uffelmann E, Vilhjalmsson BJ, Zhu Z, Smoller JW, Price AL.
medRxiv. 2024 Feb 04. PMID: 38352307
Leveraging single-cell ATAC-seq and RNA-seq to identify disease-critical fetal and adult brain cell types.
Kim SS, Truong B, Jagadeesh K, Dey KK, Shen AZ, Raychaudhuri S, Kellis M, Price AL.
Nat Commun. 2024 Jan 17. 15(1):563. PMID: 38233398
Estimating Disorder Probability Based on Polygenic Prediction Using the BPC Approach.
Uffelmann E, Price AL, Posthuma D, Peyrot WJ.
medRxiv. 2024 Jan 13. PMID: 38260678
Pervasive correlations between causal disease effects of proximal SNPs vary with functional annotations and implicate stabilizing selection.
Zhang MJ, Durvasula A, Chiang C, Koch EM, Strober BJ, Shi H, Barton AR, Kim SS, Weissbrod O, Loh PR, Gazal S, Sunyaev S, Price AL.
Res Sq. 2023 Dec 15. PMID: 38168385
News
At 170th Cutter Lecture, James Robins discusses the 'causal revolution'
At 170th Cutter Lecture, James Robins, Mitchell L. and Robin LaFoley Dong Professor of Epidemiology, discusses the "causal revolution."
New insights on genes and diseases
A person who is genetically at increased risk for developing the eating disorder anorexia appears to also have a slightly increased genetic risk for schizophrenia, but a slightly decreased genetic risk for obesity, according to a new genetic…
Probing genes for disease risk
December 5, 2014 -- New research by Alkes Price, associate professor of statistical genetics at Harvard School of Public Health, and colleagues focuses on new approaches to characterizing and identifying genetic factors in complex disease. What’s the basic…
HSPH, Dana-Farber host sixth annual quantitative genomics conference
November 27, 2012 -- What does genome-wide analysis reveal about complex human traits? What’s the best way to design and analyze gene-sequencing studies? These were some of the questions addressed at the sixth annual PQG (Program in Quantitative…
HSPH study suggests natural selection at work in certain disease-related genes
September 29, 2011 A new study led by Harvard School of Public Health (HSPH) researchers implies that, among three closely related African-ancestry populations, natural selection is at work in genes related to malaria and bladder and gastric cancers.…
