Alkes Price

Professor of Statistical Genetics

Department of Epidemiology

Department of Biostatistics

665 Huntington Avenue
Building 2, Room 211
Boston, Massachusetts 02115
Phone: 617.432.2262
aprice@hsph.harvard.edu

I am a professor in the Program in Genetic Epidemiology and Statistical Genetics in the Department of Epidemiology at HSPH, with a secondary appointment in the Department of Biostatistics.  I am an associate member of the Program in Medical and Population Genetics at the Broad Institute, and a member of the Program in Quantitative Genomics at HSPH. I am the recipient of the 2017 Harvard Chan Outstanding Postdoctoral Mentor Award. Our research focuses on the development of statistical methods for uncovering the genetic basis of human disease, and on the population genetics underlying these methods. Areas of interest include functional components of heritability, common vs. rare variant architectures, and disease mapping in structured populations.

Liability threshold modeling of family history paper (Hujoel et al. 2020) and LT-FH software
TF binding heritability paper (van de Geijn et al. 2020)
Deep learning heritability paper (Dey et al. 2020)

Functionally informed GWAS paper (Kichaev et al. 2019) and FINDOR software
Cross-population genetic correlation paper (Galinsky et al. 2019)
MAF-dependent architecture paper (Schoech et al. 2019)
Regulatory element evolution paper (Hujoel et al. 2019) (slides of ASHG 2018 talk)
Gene network connectivity paper (Kim et al. 2019)
Reconciling S-LDSC and LDAK paper (Gazal et al. 2019) and LD Score software
Polygenicity paper (O’Connor et al. 2019) and S-LD4M software
Transposable element heritability paper (Hormozdiari et al. 2019)

TWAS of schizophrenia and chromatin activity paper (Gusev et al. 2018) (slides of ASHG 2016 talk)
Heritability enrichment of specifically expressed genes paper (Finucane et al. 2018) and LD Score software (Research Highlight)
UK Biobank BOLT-LMM paper (Loh et al. 2018) and BOLT-LMM software
Heritability enrichment of molecular QTL paper (Hormozdiari et al. 2018) (slides of ASHG 2017 talk) and MaxCPP annotations
Mosaicism paper (Loh et al. 2018) (slides of ASHG 2017 talk) (News release)
ASMC paper (Palamara et al. 2018) and ASMC software (slides of ASHG 2017 talk)
Signed LD profile regression paper (Reshef et al. 2018) and SLDP software (slides of ASHG 2017 talk)
Low-frequency variant functional enrichment paper (Gazal et al. 2018) and LD Score software
Latent Causal Variable (LCV) causal inference paper (O’Connor et al. 2018) and LCV software (slides of ASHG 2017 talk)

LT-Fam paper (Hayeck et al. 2017) (slides of 2015 ASHG talk) and LTSOFT software
Summary statistics review paper (Pasaniuc & Price 2017)
Functional heritability of gene expression paper (Liu et al. 2017) and LD Score software
LD-dependent architecture paper (Gazal et al. 2017) (slides of GCD 2016 talk) and LD Score software
Multi-ethnic risk prediction paper (Marquez-Luna et al. 2017)

FastPCA selection paper (Galinsky et al. 2016) (slides of ASHG 2015 talk) and EIGENSOFT software
TWAS from summary statistics paper (Gusev et al. 2016) (slides of ASHG 2015 talk) (Research Highlight)
Prostate cancer functional heritability paper (Gusev et al. 2016)
Long-range phasing paper (Loh et al. 2016) and Eagle software
Reference-based phasing paper (Loh et al. 2016) and Eagle software
UK Biobank selection paper (Galinsky et al. 2016) (slides of ASHG 2016 talk) and EIGENSOFT software

 

List of all publications

“Everything should be made as simple as possible, but no simpler” – Albert Einstein