James Stevens Simmons Professor of Genetics and Metabolism
Molecular Metabolism
Faculty Affiliate in the Department of Nutrition
Nutrition
Harvard T.H. Chan School of Public Health
The major interest of my laboratory is to study the regulatory pathways, which control glucose and lipid metabolism. Our biochemical and genetic studies focus on signal transduction using cultured mammalian cells as well as transgenic animals to identify specific abnormalities in these pathways, which are involved in human metabolic and inflammatory diseases including obesity, diabetes, fatty liver disease, atherosclerosis, and asthma.
Tirosh A, Calay ES, Tuncman G, Claiborn KC, Inouye KE, Eguchi K, Alcala M, Rathaus M, Hollander KS, Ron I, Livne R, Heianza Y, Qi L, Shai I, Garg R, Hotamisligil GS.
Sci Transl Med. 2019 04 24. 11(489). PMID: 31019023
Prentice KJ, Saksi J, Hotamisligil GS.
J Lipid Res. 2019 04. 60(4):734-740. PMID: 30705117
Hotamisligil GS.
Immunity. 2017 09 19. 47(3):406-420. PMID: 28930657
Yu CW, Liang X, Lipsky S, Karaaslan C, Kozakewich H, Hotamisligil GS, Bischoff J, Cataltepe S.
Angiogenesis. 2016 Jan. 19(1):95-106. PMID: 26625874
Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP.
Cell Metab. 2015 Dec 01. 22(6):1045-58. PMID: 26481668
Saint-Geniez M, Ghelfi E, Liang X, Yu C, Spencer C, Abend S, Hotamisligil G, Cataltepe S.
PLoS One. 2014. 9(5):e96253. PMID: 24802082
Yalcin A, Hotamisligil GS.
Diabetes. 2013 Mar. 62(3):691-3. PMID: 23431011
Mozaffarian D, de Oliveira Otto MC, Lemaitre RN, Fretts AM, Hotamisligil G, Tsai MY, Siscovick DS, Nettleton JA.
Am J Clin Nutr. 2013 Apr. 97(4):854-61. PMID: 23407305
Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S.
Angiogenesis. 2012 Sep. 15(3):457-68. PMID: 22562362
Hotamisligil GS.
Nat Med. 2010 Apr. 16(4):396-9. PMID: 20376052