Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles.
Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q.
Sci Adv. 2023 01 27. 9(4):eade2708. PMID: 36706192
Primary Faculty
Quan Lu
Cecil K. and Philip Drinker Professor of Environmental Physiology
Environmental Health
Other Positions
Faculty Affiliate in the Department of Molecular Metabolism
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Overview
My laboratory studies molecular mechanisms underlying complex gene-environment interactions in multigenic human diseases such as asthma and neurodegeneration, focusing in part on the emerging role of extracellular vesicles in disease pathogenesis, prevention, and therapeutics. Research in my laboratory is supported by multiple NIH R01 grants and a Program Project grant as well as gifts from private companies and foundations. Here are some examples of our recent work.
Bibliography
Antagonizing cholecystokinin A receptor in the lung attenuates obesity-induced airway hyperresponsiveness.
Panganiban RAM, Yang Z, Sun M, Park CY, Kasahara DI, Schaible N, Krishnan R, Kho AT, Israel E, Hershenson MB, Weiss ST, Himes BE, Fredberg JJ, Tantisira KG, Shore SA, Lu Q.
Nat Commun. 2023 01 04. 14(1):47. PMID: 36599824
Guidelines for the prevention and management of children and adolescents with COVID-19.
Liu E, Smyth RL, Li Q, Qaseem A, Florez ID, Mathew JL, Amer YS, Estill J, Lu Q, Fu Z, Lu X, Chan ES, Schwarze J, Wong GW, Fukuoka T, Ahn HS, Lee MS, Nurdiati D, Cao B, Tu W, Qian Y, Zhao S, Dong X, Luo X, Chen Z, Li G, Zhang X, Zhao X, Xu H, Xu F, Shi Y, Zhao R, Zhao Y, Lei J, Zheng X, Wang M, Yang S, Feng X, Wu L, He Z, Liu S, Wang Q, Song Y, Luo Z, Zhou Q, Guyatt G, Chen Y, Li Q.
Eur J Pediatr. 2022 Dec. 181(12):4019-4037. PMID: 36109390
CEBPD modulates the airway smooth muscle transcriptomic response to glucocorticoids.
Kan M, Sun M, Jiang X, Diwadkar AR, Parikh V, Cao G, Gebski E, Jester W, Lan B, Panettieri RA, Koziol-White C, Lu Q, Himes BE.
Respir Res. 2022 Jul 28. 23(1):193. PMID: 35902923
Methodology and experiences of rapid advice guideline development for children with COVID-19: responding to the COVID-19 outbreak quickly and efficiently.
Zhou Q, Li Q, Estill J, Wang Q, Wang Z, Shi Q, Zhang J, Zhang X, Mathew JL, Smyth RL, Nurdiati D, Fu Z, Xu H, Zheng X, Zhao X, Lu Q, Liu H, Xun Y, Li W, Yang S, Feng X, Wang M, Lei J, Luo X, Wu L, Lu X, Lee MS, Zhao S, Chan ES, Qian Y, Tu W, Dong X, Li G, Zhao R, He Z, Zhao S, Liu X, Li Q, Yang K, Luo Z, Liu E, Chen Y.
BMC Med Res Methodol. 2022 04 03. 22(1):89. PMID: 35369859
A Long Noncoding RNA "lnc"ed to Asthma Genetics.
Panganiban RA, Lu Q.
Am J Respir Cell Mol Biol. 2022 03. 66(3):243-244. PMID: 35030310
Electronic cigarette smoke reduces ribosomal protein gene expression to impair protein synthesis in primary human airway epithelial cells.
Park HR, Vallarino J, O'Sullivan M, Wirth C, Panganiban RA, Webb G, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q.
Sci Rep. 2021 09 01. 11(1):17517. PMID: 34471210
Release of particulate matter from nano-enabled building materials (NEBMs) across their lifecycle: Potential occupational health and safety implications.
Singh D, Marrocco A, Wohlleben W, Park HR, Diwadkar AR, Himes BE, Lu Q, Christiani DC, Demokritou P.
J Hazard Mater. 2022 01 15. 422:126771. PMID: 34391975
Drug Repurposing to Treat Glucocorticoid Resistance in Asthma.
Wang AL, Panganiban R, Qiu W, Kho AT, Chupp G, Meyers DA, Bleecker ER, Weiss ST, Lu Q, Tantisira KG.
J Pers Med. 2021 Mar 03. 11(3). PMID: 33802355
COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma.
Tiwari A, Li J, Kho AT, Sun M, Lu Q, Weiss ST, Tantisira KG, McGeachie MJ.
J Allergy Clin Immunol. 2021 06. 147(6):2181-2190. PMID: 33385444
News
New vaccine platform could aid in fight against deadly viruses
Researchers at Harvard Chan School have developed a new, highly adaptable vaccine platform that could potentially be a powerful tool in the fight against viral pathogens including influenza, HIV, and SARS-CoV-2.
Mechanism behind obesity-related asthma identified
Ronald Panganiban, research scientist in the Department of Environmental Health at Harvard T.H. Chan School of Public Health, discusses a recent paper he co-authored with Quan Lu, Cecil K and Philip Drinker Professor of Environmental Physiology, and other…
New Superfund Research Center will explore metals’ effects on cognitive health
March 6, 2020 – Harvard T.H. Chan School of Public Health has been awarded a five-year, multimillion-dollar federal grant to establish a Superfund Research Center to study the effects of metals and metal mixtures on cognitive health in…
Why is vaping sickening and killing people? Experts don’t know yet.
Scientists are scrambling to figure out more about the vaping illness that has sickened roughly 1,300 and killed at least 29 in the U.S. Some experts are looking to see whether oily chemicals added to vaping liquids are…
When cells reach their breaking point
For cells, effectively managing stress can be the difference between life and death. But why some cells master the art of stress management while others succumb to the pressure isn’t well understood. June 25, 2019—Researchers led by Quan…
