COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma.
Tiwari A, Li J, Kho AT, Sun M, Lu Q, Weiss ST, Tantisira KG, McGeachie MJ.
J Allergy Clin Immunol. 2020 Dec 29. PMID: 33385444
Professor
Quan Lu
Other Positions
Faculty Affiliate in the Department of Molecular Metabolism
Molecular Metabolism
Harvard T.H. Chan School of Public Health
Overview
My laboratory studies molecular mechanisms underlying complex gene-environment interactions in multigenic human diseases such as asthma and neurodegeneration, focusing in part on the emerging role of extracellular vesicles in disease pathogenesis, prevention, and therapeutics. Research in my laboratory is supported by multiple NIH R01 grants and a Program Project grant as well as gifts from private companies and foundations. Here are some examples of our recent work.
Bibliography
Circulating MicroRNAs and Treatment Response in Childhood Asthma.
Li J, Panganiban R, Kho AT, McGeachie MJ, Farnam L, Chase RP, Weiss ST, Lu Q, Tantisira KG.
Am J Respir Crit Care Med. 2020 07 01. 202(1):65-72. PMID: 32272022
MicroRNA-124 Reduces Arsenic-induced Endoplasmic Reticulum Stress and Neurotoxicity and is Linked with Neurodevelopment in Children.
Park HR, Sun R, Panganiban RA, Christiani DC, Lu Q.
Sci Rep. 2020 04 03. 10(1):5934. PMID: 32246005
Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy.
McGeachie MJ, Sordillo JE, Dahlin A, Wang AL, Lutz SM, Tantisira KG, Panganiban R, Lu Q, Sajuthi S, Urbanek C, Kelly R, Saef B, Eng C, Oh SS, Kho AT, Croteau-Chonka DC, Weiss ST, Raby BA, Mak ACY, Rodriguez-Santana JR, Burchard EG, Seibold MA, Wu AC.
Respir Res. 2020 Jan 28. 21(1):31. PMID: 31992292
Hyperinsulinemia promotes heterologous desensitization of ß2 adrenergic receptor in airway smooth muscle in obesity.
Xu R, Gopireddy RR, Wu Y, Wu L, Tao X, Shao J, Wang W, Li L, Jovanovic A, Xu B, Kenyon NJ, Lu Q, Xiang YK, Fu Q.
FASEB J. 2020 03. 34(3):3996-4008. PMID: 31960515
Delayed administration of recombinant plasma gelsolin improves survival in a murine model of severe influenza.
Yang Z, Bedugnis A, Levinson S, DiNubile M, Stossel T, Lu Q, Kobzik L.
F1000Res. 2019. 8:1860. PMID: 31824672
Shared genetic and experimental links between obesity-related traits and asthma subtypes in UK Biobank.
Zhu Z, Guo Y, Shi H, Liu CL, Panganiban RA, Chung W, O'Connor LJ, Himes BE, Gazal S, Hasegawa K, Camargo CA, Qi L, Moffatt MF, Hu FB, Lu Q, Cookson WOC, Liang L.
J Allergy Clin Immunol. 2020 02. 145(2):537-549. PMID: 31669095
Delayed Administration of Recombinant Plasma Gelsolin Improves Survival in a Murine Model of Penicillin-Susceptible and Penicillin-Resistant Pneumococcal Pneumonia.
Yang Z, Bedugnis A, Levinson S, Dinubile M, Stossel T, Lu Q, Kobzik L.
J Infect Dis. 2019 09 26. 220(9):1498-1502. PMID: 31287867
Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis.
Panganiban RA, Park HR, Sun M, Shumyatcher M, Himes BE, Lu Q.
Proc Natl Acad Sci U S A. 2019 07 02. 116(27):13384-13393. PMID: 31213543
Transcriptomic response of primary human airway epithelial cells to flavoring chemicals in electronic cigarettes.
Park HR, O'Sullivan M, Vallarino J, Shumyatcher M, Himes BE, Park JA, Christiani DC, Allen J, Lu Q.
Sci Rep. 2019 02 01. 9(1):1400. PMID: 30710127
News
New Superfund Research Center will explore metals’ effects on cognitive health
March 6, 2020 – Harvard T.H. Chan School of Public Health has been awarded a five-year, multimillion-dollar federal grant to establish a Superfund Research Center to study the effects of metals and metal mixtures on cognitive health in…
Why is vaping sickening and killing people? Experts don’t know yet.
Scientists are scrambling to figure out more about the vaping illness that has sickened roughly 1,300 and killed at least 29 in the U.S. Some experts are looking to see whether oily chemicals added to vaping liquids are…
When cells reach their breaking point
For cells, effectively managing stress can be the difference between life and death. But why some cells master the art of stress management while others succumb to the pressure isn’t well understood. June 25, 2019—Researchers led by Quan…
Breakthrough brings targeted drug delivery within ARMM's reach
Scientists at Harvard T.H. Chan School of Public Health demonstrated a new vesicle-based system for delivering molecular cargo into cells—a discovery that may significantly improve targeted drug delivery.
Gene linked with lower asthma risk identified
Researchers from Harvard T.H. Chan School of Public Health have identified a gene associated with lower asthma risk and its role in the disease’s progression—findings that open a new potential pathway for treatment.
