Stephanie Smith-Warner
Lecturer

Stephanie Smith-Warner

Senior Lecturer

Nutrition

swarner@hsph.harvard.edu

Other Positions

Faculty Affiliate in the Department of Epidemiology

Epidemiology

Harvard T.H. Chan School of Public Health


Overview

My research has primarily focused on nutrition and cancer epidemiology. Main themes of my research have been determination of the role of plant-based diets, particularly fruit and vegetable intake, alcohol consumption, and more recently, vitamin D in the development of both common and less common cancers. Much of my research has been conducted in two international consortia that I have been leading/co-leading for over 16 years: the Pooling Project of Prospective Studies of Diet and Cancer (DCPP) and the Circulating Biomarkers and Breast and Colorectal Cancer Consortium (BBC3). Additionally, I have participated in several analyses of dietary factors including dietary patterns, anthropometric factors, and biomarkers within the Nurses' Health Study, Nurses' Health Study II, and Health Professionals Follow-Up Study, three large prospective cohort studies.

The Pooling Project of Prospective Studies of Diet and Cancer (DCPP) is an international consortium that was established in 1993 to examine associations between dietary and anthropometric factors and breast cancer risk. Since then, we have also evaluated associations with several other cancers including lung, colorectal, renal cell, ovarian, pancreatic, and prostate cancer, as well as amyotrophic lateral sclerosis and coronary heart disease. It provides a large collection of prospective data from which large-scale, comprehensive assessments of the role of nutrition (nutrients, foods, and anthropometry) in the risk of several cancers and other chronic diseases have been investigated. The consortium now includes over 35 cohort studies with over 2.5 million participants from 16 countries.

The Circulating Biomarkers and Breast and Colorectal Cancer Consortium (BBC3) was established in 2010 to examine associations between circulating 25(OH)D and risk of breast and colorectal cancers, overall and by tumor subtype and population subgroup. These initial analyses included 21 cohorts from North America, Europe, and Asia. The consortium is currently being expanded to examine additional biomarkers for these two cancers.

For both consortia, participant level data on the exposures of interest, confounding variables, and outcomes from each study have been centralized and harmonized and analyses have been conducted using standardized criteria across studies.


Bibliography

Corrigendum to 'Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer': [Annals of Oncology Volume 31, Issue 1, January 2020, Pages 103-114].

Genkinger JM, Wu K, Wang M, Albanes D, Black A, van den Brandt PA, Burke KA, Cook MB, Gapstur SM, Giles GG, Giovannucci E, Goodman GG, Goodman PJ, Håkansson N, Key TJ, Männistö S, Le Marchand L, Liao LM, MacInnis RJ, Neuhouser ML, Platz EA, Sawada N, Schenk JM, Stevens VL, Travis RC, Tsugane S, Visvanathan K, Wilkens LR, Wolk A, Smith-Warner SA.

Ann Oncol. 2021 Jul 06. PMID: 34244036

Recommended Definitions of Aggressive Prostate Cancer for Etiologic Epidemiologic Research.

Hurwitz LM, Agalliu I, Albanes D, Barry KH, Berndt SI, Cai Q, Chen C, Cheng I, Genkinger JM, Giles GG, Huang J, Joshu CE, Key TJ, Knutsen S, Koutros S, Langseth H, Li SX, MacInnis RJ, Markt SC, Penney KL, Perez-Cornago A, Rohan TE, Smith-Warner SA, Stampfer MJ, Stopsack KH, Tangen CM, Travis RC, Weinstein SJ, Lang PhD W, Jacobs EJ, Mucci LA, Platz EA, Cook MB.

J Natl Cancer Inst. 2021 Jun 01. 113(6):727-734. PMID: 33010161

Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies.

Wu Y, Huang R, Wang M, Bernstein L, Bethea TN, Chen C, Chen Y, Eliassen AH, Freedman ND, Gaudet MM, Gierach GL, Giles GG, Krogh V, Larsson SC, Liao LM, McCullough ML, Miller AB, Milne RL, Monroe KR, Neuhouser ML, Palmer JR, Prizment A, Reynolds P, Robien K, Rohan TE, Sandin S, Sawada N, Sieri S, Sinha R, Stolzenberg-Solomon RZ, Tsugane S, van den Brandt PA, Visvanathan K, Weiderpass E, Wilkens LR, Willett WC, Wolk A, Zeleniuch-Jacquotte A, Ziegler RG, Smith-Warner SA.

Am J Clin Nutr. 2021 May 08. PMID: 33964859


News

Higher vitamin D levels may lower colorectal cancer risk

Higher blood concentrations of vitamin D are linked to a lower risk of colorectal cancer, especially in women, according to a large new study from researchers at Harvard T.H. Chan School of Public Health, the National Cancer Institute,…