New insights into mechanism behind tuberous sclerosis complex tumors

Findings by Harvard School of Public Health’s Brendan Manning, professor of genetics and complex diseases, are providing new insights into tuberous sclerosis complex (TSC) — a rare genetic disease that causes the widespread growth of benign tumors — and may ultimately lead to treatment. His work characterizes the molecular mechanisms involved with the functional loss in one of two genes that ultimately leads to TSC tumors.

Manning’s research, which was funded by the U.S. Department of Defense Tuberous Sclerosis Complex Research Program, was highlighted on the Congressionally Directed Medical Research Programs website on November 12, 2014.

Defining the Balance between Protein Synthesis and Degradation by mTORC1 in Tuberous Sclerosis Complex (Congressionally Directed Medical Research Programs)