Mair Lab

Carlos Giovanni Silva-García

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Postdoc

cgsilva [at] hsph.harvard.edu

Fellowships:

  • Harvard Yerby Fellowship Program
  • Aramont Fellowship Fund
  • K99/R00 NIH/NIA Pathway to Independence Award

Area of Interest/Research Focus:

My broad scientific interests lie in understanding genetic and non-genetic mechanisms that regulate aging and aging-related diseases. In particular, I am interested to study how molecular and cellular mechanisms of external signals that promote longevity regulate epigenetic and metabolic changes; how it impacts the age-related diseases, and whether these conditions (positive or negative) can be transmitted to next generations. In the Mair lab, I study how epigenetic marks reprogram transcriptional networks to promote longevity using cutting-edge techniques such as CRISPR to develop novel approaches to study the aging process.

Publications:

Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans
Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. G3 (Bethesda). 2019 Jul 9;9(7):2195-2198. doi: 10.1534/g3.119.400314.

Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans.
Zhang Y, Lanjuin A, Chowdhury SR, Mistry M, Silva-García CG, Weir HJ, Lee CL, Escoubas CC, Tabakovic E, Mair WB. Elife. 2019 Aug 14;8:e49158. doi: 10.7554/eLife.49158.

Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Han S, Schroeder EA, Silva-García CG, Hebestreit K, Mair WB, Brunet A.
Nature. 2017 Apr 13;544(7649):185-190. doi: 10.1038/nature21686. Epub 2017 Apr 5.

Deregulation of CRTCs in Aging and Age-Related Disease Risk.
Escoubas CC, Silva-García CG, Mair WB.
Trends Genet. 2017 May;33(5):303-321. doi: 10.1016/j.tig.2017.03.002. Epub 2017 Mar 30. Review.

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.

Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB.
Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5.

The Stress Granule RNA-Binding Protein TIAR-1 Protects Female Germ Cells from Heat Shock in Caenorhabditis elegans.

Huelgas-Morales G, Silva-García CG, Salinas LS, Greenstein D, Navarro RE.
G3 (Bethesda). 2016 Apr 7;6(4):1031-47. doi: 10.1534/g3.115.026815.

LIN-35/Rb causes starvation-induced germ cell apoptosis via CED-9/Bcl2 downregulation in Caenorhabditis elegans.
Láscarez-Lagunas LI, Silva-García CG, Dinkova TD, Navarro RE.
Mol Cell Biol. 2014 Jul;34(13):2499-516. doi: 10.1128/MCB.01532-13. Epub 2014 Apr 21.

The C. elegans TIA-1/TIAR homolog TIAR-1 is required to induce germ cell apoptosis.
Silva-García CG, Estela Navarro R.
Genesis. 2013 Oct;51(10):690-707. doi: 10.1002/dvg.22418. Epub 2013 Aug 30.

Germ granules: Vehicles for germ cell Determination.
Maldonado E, Barbosa V, Bezares-Calderón LA, Castillo-Robles J, Franco-Cea A, Hansberg V, Láscarez-Lagunas LI, Paz-Gómez D, Salinas LS, Silva-García CG and Navarro RE. Topics in Animal and Plant Development: From Cell Differentiation to Morphogenesis. 2011 ISBN: 978-81-7895-506-3 Editor: Chimal-Monroy J.