Mitochondria are the main fuel producers in our cells, and exist as a dynamic network that can alternate between a fused and fragmented state depending upon age, nutrient conditions and damage. Growing evidence links the dynamic state of mitochondrial networks to metabolic efficiency. We have shown that neural CRTC-1 drives mitochondrial fission cell non autonomously in other tissues, inhibiting mitochondrial metabolism and modulating lifespan. Furthermore, we demonstrated a key ancestral role for the circadian regulator Bmal1/AHA-1 in C. elegans is promoting longevity via fusion of mitochondrial networks.
- Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling.
Weir HJ, Yao P, Huynh FK, Escoubas CC, Goncalves RL, Burkewitz K, Laboy R, Hirschey MD, Mair WB
Cell Metabolism.2017 Oct 23. pii: S1550-4131(17)30612-5. doi: 10.1016/j.cmet.2017.09.024. [Epub ahead of print]
- Neuronal CRTC-1 governs systemic mitochondrial metabolism and lifespan via a catecholamine signal.
Burkewitz K, Morantte I, Weir HJ, Yeo R, Zhang Y, Huynh FK, Ilkayeva OR, Hirschey MD, Grant AR, Mair WB.
Cell. 2015 Feb 26;160(5):842-55. doi: 10.1016/j.cell.2015.02.004.
- Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness.
Jacobi D, Liu S, Burkewitz K, Kory N, Knudsen NH, Alexander RK, Unluturk U, Li X, Kong X, Hyde AL, Gangl MR, Mair WB, Lee CH.
Cell Metab. 2015 Oct 6;22(4):709-20. doi: 10.1016/j.cmet.2015.08.006. Epub 2015 Sep 10.