Caroline Heintz

Caroline

 

 

 

 

Senior Research Fellow

caheintz [at] hsph.harvard.edu

Fellowships:

  • Charles A. King Trust Postdoctoral Research Fellowship, The Medical Foundation, MA, USA (2017-2019)
  • AFR Postdoctoral Fellowship, Fonds National de la Recherche, Luxembourg (2015-2017)
  • Early Postdoc Mobility Fellowship, Swiss National Science Foundation (2014-2015)

Area of Interest/Research Focus:

(TBA)

Publications:

Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans
Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. G3 (Bethesda). 2019 Jul 9;9(7):2195-2198. doi: 10.1534/g3.119.400314.


Alternative splicing in aging and longevity
Bhadra M, Howell P,Dutta S, Heintz C, Mair WB. Hum Genet. 2020 Mar;139(3):357-369. doi: 10.1007/s00439-019-02094-6. Epub 2019 Dec 13.


Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.
Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB.
Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5.


Co-expression of phenylalanine hydroxylase variants and effects of interallelic complementation on in vitro enzyme activity and genotype-phenotype correlation.
Shen N, Heintz C, Thiel C, Okun JG, Hoffmann GF, Blau N.
Mol Genet Metab. 2016 Mar;117(3):328-35. doi: 10.1016/j.ymgme.2016.01.004. Epub 2016 Jan 12.


You are what you host: microbiome modulation of the aging process.
Heintz C, Mair W.
Cell. 2014 Jan 30;156(3):408-11. doi: 10.1016/j.cell.2014.01.025. Review.


Tetrahydrobiopterin, its mode of action on phenylalanine hydroxylase, and importance of genotypes for pharmacological therapy of phenylketonuria.
Heintz C, Cotton RG, Blau N.
Hum Mutat. 2013 Jul;34(7):927-36. doi: 10.1002/humu.22320. Epub 2013 May 1. Review.


Splicing of phenylalanine hydroxylase (PAH) exon 11 is vulnerable: molecular pathology of mutations in PAH exon 11.
Heintz C, Dobrowolski SF, Andersen HS, Demirkol M, Blau N, Andresen BS.
Mol Genet Metab. 2012 Aug;106(4):403-11. doi: 10.1016/j.ymgme.2012.05.013. Epub 2012 May 29.


Quantification of phenylalanine hydroxylase activity by isotope-dilution liquid chromatography-electrospray ionization tandem mass spectrometry.
Heintz C, Troxler H, Martinez A, Thöny B, Blau N.
Mol Genet Metab. 2012 Apr;105(4):559-65. doi: 10.1016/j.ymgme.2011.12.025. Epub 2012 Jan 12.


Molecular genetics and impact of residual in vitro phenylalanine hydroxylase activity on tetrahydrobiopterin responsiveness in Turkish PKU population.
Dobrowolski SF, Heintz C, Miller T, Ellingson C, Ellingson C, Ozer I, Gökçay G, Baykal T, Thöny B, Demirkol M, Blau N.
Mol Genet Metab. 2011 Feb;102(2):116-21. doi: 10.1016/j.ymgme.2010.11.158. Epub 2010 Nov 18.


Genotype-predicted tetrahydrobiopterin (BH4)-responsiveness and molecular genetics in Croatian patients with phenylalanine hydroxylase (PAH) deficiency.
Karacić I, Meili D, Sarnavka V, Heintz C, Thöny B, Ramadza DP, Fumić K, Mardesić D, Barić I, Blau N. Mol Genet Metab. 2009 Jul;97(3):165-71. doi: 10.1016/j.ymgme.2009.03.009. Epub 2009 Apr 1.


Tumor necrosis factor alpha inhibits erythroid differentiation in human erythropoietin-dependent cells involving p38 MAPK pathway, GATA-1 and FOG-1 downregulation and GATA-2 upregulation.
Buck I, Morceau F, Cristofanon S, Heintz C, Chateauvieux S, Reuter S, Dicato M, Diederich M. Biochem Pharmacol. 2008 Nov 15;76(10):1229-39. doi: 10.1016/j.bcp.2008.08.025. Epub 2008 Sep 2.


A simple selection strategy for evolving highly efficient enzymes.
Neuenschwander M, Butz M, Heintz C, Kast P, Hilvert D.
Nat Biotechnol. 2007 Oct;25(10):1145-7. Epub 2007 Sep 16.