Sneha Dutta

Graduate Student

snehadutta [at]

Area of Interest/Research Focus:

My research is driven towards understanding the role of RNA homeostasis in the process of aging. Combining C. elegans and mammalian cell culture studies, I am trying to unravel interesting links between various metabolic pathways implicated in longevity and the components of the RNA splicing machinery.


Atf-6Regulates Lifespan through ER-MitochondrialCalcium Homeostasis
Burkewitz K, Dutta S, Kelley CA, Steinbaugh M, Cram E, Mair WB.  Cell Reports, 2020 Cell Rep. 2020 Sep 8;32(10):108125. doi: 10.1016/j.celrep.2020.108125.

Alternative splicing in aging and longevity.

Bhadra M, Howell P, Dutta S, Heintz C, Mair WB. Hum Genet. 2020 Mar;139(3):357-369. doi: 10.1007/s00439-019-02094-6. Epub 2019 Dec 13.

Single-Copy Knock-In Loci for Defined Gene Expression in Caenorhabditis elegans.

Silva-García CG, Lanjuin A, Heintz C, Dutta S, Clark NM, Mair WB. G3 (Bethesda). 2019 Jul 9;9(7):2195-2198. doi: 10.1534/g3.119.400314.

Strain-transcending neutralization of malaria parasite by antibodies against Plasmodium falciparum enolase.
Dutta S, Tewari A, Balaji C, Verma R, Moitra A, Yadav M, Agrawal P, Sahal D, Jarori GK.
Malar J. 2018 Aug 20;17(1):304. doi: 10.1186/s12936-018-2455-6.

Functions of tryptophan residues in EWGWS insert of Plasmodium falciparum enolase.
Dutta S, Moitra A, Mukherjee D, Jarori GK.
FEBS Open Bio. 2017 Jun 5;7(7):892-904. doi: 10.1002/2211-5463.12242. eCollection 2017 Jul.

Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans.
Heintz C, Doktor TK, Lanjuin A, Escoubas C, Zhang Y, Weir HJ, Dutta S, Silva-García CG, Bruun GH, Morantte I, Hoxhaj G, Manning BD, Andresen BS, Mair WB.
Nature. 2017 Jan 5;541(7635):102-106. doi: 10.1038/nature20789. Epub 2016 Dec 5.

Immunogenicity and protective potential of a Plasmodium spp. enolase peptide displayed on archaeal gas vesicle nanoparticles.
Dutta S, DasSarma P, DasSarma S, Jarori GK.
Malar J. 2015 Oct 14;14:406. doi: 10.1186/s12936-015-0914-x.

Cloning, expression, purification and characterization of Plasmodium spp. glyceraldehyde-3-phosphate dehydrogenase.
Sangolgi PB, Balaji C, Dutta S, Jindal N, Jarori GK.
Protein Expr Purif. 2016 Jan;117:17-25. doi: 10.1016/j.pep.2015.08.028. Epub 2015 Sep 1.

Replacement of Ser108 in Plasmodium falciparum enolase results in weak Mg(II) binding: role of a parasite-specific pentapeptide insert in stabilizing the active conformation of the enzyme.
Dutta S, Mukherjee D, Jarori GK.
FEBS J. 2015 Jun;282(12):2296-308. doi: 10.1111/febs.13272. Epub 2015 Apr 11.

Food vacuole associated enolase in plasmodium undergoes multiple post-translational modifications: evidence for atypical ubiquitination.
Shevade S, Jindal N, Dutta S, Jarori GK.
PLoS One. 2013 Aug 23;8(8):e72687. doi: 10.1371/journal.pone.0072687. eCollection 2013.