Publications

View our published work below or visit Google Scholar.

Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 severity.
Zintis Inde, Ben A. Croker (co-first author), Clarence Yapp, Gaurav Joshi, Johan Spetz, Cameron Fraser, Xingping Qin, Le Xu, Brian Deskin, Elisa Ghelfi, Gabrielle Webb, Aaron F. Carlin, Yangfei Peipei Zhu, Sandra Leibel, Aaron F. Garretson, Alex E. Clark, Jason M. Duran, Victor Pretorius, Laura E. Crotty-Alexander, Chendi Li, Jamie Casey Lee, Chhinder Sodhi, David J. Hackam, Xin Sun, Aaron Hata, Lester Kobzik, Jeffrey Miller, Jin-Ah Park, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek.
Science Advances, August 18, 2021. PDF. PubMed.
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics.
Veerle W. Daniels, Jason J. Zoeller, Nick van Gastel, Kelley E. McQueeney, Salma Parvin, Danielle S. Potter, Geoffrey G. Fell, Vinícius G. Ferreira, Binyam Yilma, Rajat Gupta, Johan Spetz, Patrick D. Bhola, Jennifer E. Endress, Isaac S. Harris, Emanuel Carrilho, Kristopher Sarosiek, David T. Scadden, Joan S. Brugge, Anthony Letai
Science Signaling, 2021 June 8. PubMed.
Short-term exposure to ambient particle gamma radioactivity is associated with increased risk for all-cause non-accidental and cardiovascular mortality.
Shaodan Huang, Jianyin Xiong, Carolina LZ Vieira, Annelise J Blomberg, Diane R Gold, Brent A Coull, Kristopher Sarosiek, Joel D Schwartz, Jack M Wolfson, Jing Li, Petros Koutrakis.
Science of The Total Environment, 2020 June 15. PubMed.
Age-dependent regulation of SARS-CoV-2 cell entry genes and cell death programs correlates with COVID-19 disease severity (Preprint).
Zintis Inde, Clarence Yapp, Gaurav Joshi, Johan Spetz, Cameron Fraser, Brian Deskin, Elisa Ghelfi, Chhinder Sodhi, David J. Hackam, Lester Kobzik, Ben A. Croker, Douglas Brownfield, Hongpeng Jia, Kristopher A. Sarosiek.
BioRxiv, September 13, 2020. PDF. BioRxiv.
HSF1 phase transition mediates stress adaptation and cell fate decisions.
Giorgio Gaglia, Rumana Rashid, Clarence Yapp, Gaurav Joshi, Carmen G. Li, Susan L. Lindquist, Kristopher Sarosiek, Luke Whitesell, Peter K. Sorger & Sandro Santagata.
Nature Cell Biology, 2020 Feb 03. PubMed.
Safer-by-design Flame-Sprayed Silicon Dioxide Nanoparticles: The Role of Silanol Content on ROS Generation, Surface Activity and Cytotoxicity.
Laura Rubio, Georgios Pyrgiotakis, Juan Beltran-Huarac, Yipei Zhang, Gaurav Joshi, Glen Deloid, Anastasia Spyrogianni, Kristopher Sarosiek, Dhimiter Bello, Philip Demokritou.
Particle and Fibre Toxicology, 2019 Oct 29. PubMed.
Pooled genomic screens identify anti-apoptotic genes as targetable mediators of chemotherapy resistance in ovarian cancer.
Stover EH, Baco MB, Cohen O, Li YY, Christie EL, Bagul M, Goodale A, Lee Y, Pantel S, Rees MG, Wei G, Adam Presser, Gelbard MK, Zhang W, Zervantonakis IK, Bhola PD, Ryan J, Guerriero JL, Montero J, Liang FJ, Cherniack AD, Piccioni F, Matulonis UA, Bowtell DDL, Kristopher Sarosiek, Letai A, Garraway LA, Johannessen CM, Meyerson M.
Molecular Cancer Research, 2019 Aug 28. PubMed.
Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.
Chen Lossos, Yunpeng Liu, Kellie E. Kolb, Amanda L. Christie, Alexandria Van Scoyk, Sanjay M. Prakadan, Kay Shigemori, Kristen E. Stevenson, Sara Morrow, Olivia D. Plana, Cameron Fraser, Kristen L. Jones, Huiyun Liu, Christian P. Pallasch, Rebecca Modiste, Quang-De Nguyen, Jeffrey W. Craig, Elizabeth A. Morgan, Francisco Vega, Jon C. Aster, Kristopher A. Sarosiek, Alex K. Shalek, Michael T. Hemann and David M. Weinstock
Cancer Discovery, 2019 April 30. PubMed.

Clonal plasma cells in AL amyloidosis are dependent on pro survival BCL-2 family proteins and sensitive to BH3 mimetics (Preprint).
Cameron Fraser, Adam Presser, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A. Sarosiek.
BioRxiv, February 6 2019. PDF. BioRxiv.

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins (Review) (Featured on cover).
Rumani Singh, Anthony Letai, Kristopher A. Sarosiek.
Nature Reviews Molecular Cell Biology, 2019 Jan 17. PDF. PubMed.

BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies (Protocol).
Cameron Fraser, Jeremy Ryan, Kristopher A. Sarosiek.
Methods in Molecular Biology, January 2019;1877:61-76. PDF. PubMed.

Exploiting MCL-1 dependency with combination MEK + MCL-1 inhibitors leads to induction of apoptosis and tumor regression in KRAS mutant non-small cell lung cancer.
Varuna Nangia, Faria M Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A Ferris, Michael Lanuti, Cameron D Wright, Kevin A Raskin, Daniel P Cahill, John H Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G Azzoli, Justin F. Gainor, Kristopher Sarosiek, Sean P Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata.
Cancer Discovery, 2018 Sep 25. PubMed.
Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Kristopher Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Ryan E. Looper, Keith L. Ligon, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, Jr.
Cell, 2018 Sep 13. PubMed.
T Cells and Regulated Cell Death: Kill or Be Killed (Review).
Johan Spetz, Adam Presser, Kristopher A. Sarosiek.
International Review of Cell and Molecular Biology, 2018 September. PDF. PubMed.

Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment (Review).
Johan Spetz, Javid Moslehi, Kristopher A. Sarosiek.
Current Treatment Options in Cardiovascular Medicine, 2018 April (20:31). PDF. PubMed.

Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.
Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai & Derrick J. Rossi
Nature Cell Biology, 2018 Mar 12. PubMed.
BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
Sophie de Carné Trécesson, Frédérique Souazé, Agnès Basseville, Anne-Charlotte Bernard, Jessie Pécot, Jonathan Lopez, Margaux Bessou, Kristopher A. Sarosiek, Anthony Letai, Sophie Barillé-Nion, Isabelle Valo, Olivier Coqueret, Catherine Guette, Mario Campone, Fabien Gautier & Philippe Paul Juin
Nature Communications, 2017 Oct 24;8(1):1123. PubMed.
Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.
Viswanath Gunda, Kristopher A. Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parangi
Cancer Letters, 2017 Jun 1;395:1-10. PubMed.
Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics.
Kristopher A. Sarosiek, Cameron Fraser, Nathiya Muthalagu, Patrick D. Bhola, Weiting Chang, Samuel K. McBrayer, Adam Cantlon, Sudeshna Fisch, Gail Golomb-Mello, Jeremy M. Ryan, Jing Deng, Brian Jian, Chris Corbett, Marti Goldenberg, Joseph R. Madsen, Ronglih Liao, Dominic Walsh, John Sedivy, Daniel J. Murphy, Daniel Ruben Carrasco, Shenandoah Robinson, Javid Moslehi, Anthony G. Letai.
Cancer Cell, 2017 Jan 9: 31(1):142-156. PDF. Supplemental Data. PubMed.
CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
Shawn F. Johnson, Cristina Cruz, Ann Katrin Greifenberg, Sofia Dust, Daniel G. Stover, David Chi, Benjamin Primack, Shiliang Cao, Andrea J. Bernhardy, Rhiannon Coulson, Jean-Bernard Lazaro, Bose Kochupurakkal, Heather Sun, Christine Unitt, Lisa A. Moreau, Kristopher A. Sarosiek, Maurizio Scaltriti, Dejan Juric, Jose´ Baselga, Andrea L. Richardson, Scott J. Rodig, Alan D. D’Andrea, Judith Balmana, Neil Johnson, Matthias Geyer, Violeta Serra, Elgene Lim, and Geoffrey I. Shapiro.
Cell Reports, 2016 Nov 22: 17(9):2367-2381. PubMed.
Interleukin 21 – its potential role in the therapy of B-cell lymphomas (Review)
Shruti Bhatt, Kristopher Sarosiek, Izidore Lossos.
Leukemia & Lymphoma, 2016 Jul 13:1-13. PubMed.
Clonal evolution in patients with chronic lymphocytic leukemia developing resistance to BTK inhibition.
Jan A. Burger, Dan A. Landau, Amaro Taylor-Weiner, Ivana Bozic, Huidan Zhang, Kristopher A. Sarosiek, Lili Wang, Chip Stewart, Jean Fan, Julia Hoellenriegel, Mariela Sivina, Adrian M. Dubuc, Cameron Fraser, Yulong Han, Shuqiang Li, Kenneth J. Livak, Lihua Zou, Youzhong Wan, Sergej Konoplev, Carrie Sougnez, Lynne V. Abruzzo, Scott L. Carter, Michael J. Keating, Matthew S. Davids, William G. Wierda, Kristian Cibulskis, Thorsten Zenz, Lillian Werner, Paola Dal Cin, Peter Kharchencko, Donna Neuberg, Hagop Kantarjian, Eric Lander, Stacey Gabriel, Susan O’Brien, Anthony Letai, David A. Weitz, Martin A. Nowak, Gad Getz, Catherine J. Wu.
Nature Communications, 2016 May 20;7:11589. PubMed.
FebsDirectly targeting the mitochondrial pathway of apoptosis for cancer therapy: recent success, current challenges and future promise (Review) (Featured on cover).
Kristopher Sarosiek, Anthony Letai.
FEBS Journal, 2016 Mar 21. PDF. PubMed.

Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.
Janic Le Pen, Maillet Laurent, Kristopher A. Sarosiek, Céline Vuillier, Fabien Gautier, Sylvie Montessuit, Jean Claude Martinou, Anthony Letai, Frédérique Braun, Philippe P. Juin.
Cell Death and Disease, 4 Feb 2016. PubMed.
Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, Dekuang Zhao, Xiaoyu Jiang, Elif Isik, Anthony Letai, Izidore S. Lossos.
Blood, 24 Sep 2015. PubMed.
Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
Joan Montero, Kristopher A. Sarosiek, Joseph D. DeAngelo, Ophélia Maertens, Jeremy Ryan, Dalia Ercan, Huiying Piao, Neil S. Horowitz, Ross S. Berkowitz, Ursula Matulonis, Pasi A. Jänne, Philip C. Amrein, Karen Cichowski , Ronny Drapkin, Anthony Letai.
Cell, 26 Feb 2015, 6;160(5):977-89. PubMed.
Ras effector pathways drive resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
Peter S. Winter, Kristopher A. Sarosiek, Kevin H. Lin, Manja Meggendorfer, Susanne Schnittger, Anthony G. Letai, and Kris C. Wood.
Science Signaling, 23 Dec 2014. PubMed.
Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers
Aaron N. Hata, Alan Yeo, Anthony C. Faber, Eugene Lifshits, Zhao Chen, Katherine A. Cheng, Zandra Walton, Kristopher A. Sarosiek, Anthony Letai, Rebecca S. Heist, Mari Mino-Kenudson, Kwok-Kin Wong and Jeffrey A. Engelman.
Cancer Research, 2014, June 1. PubMed.
Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
Neil Johnson, Shawn F. Johnson, Wei Yao, Yu-Chen Li, Young-Eun Choi, Andrea J. Bernhardy, Yifan Wang, Marzia Capelletti, Kristopher A. Sarosiek, Lisa A. Moreau, et al.
Proceedings of the National Academy of Sciences USA, 2013, Oct 1. PubMed.
molcellBID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response.
Kristopher A. Sarosiek , Xiaoke Chi, John A. Bachman, Joshua J. Sims, Joan Montero, Luv Patel, Annabelle Flanagan, David W. Andrews, Peter Sorger, Anthony Letai.
Molecular Cell, 26 September 2013. PDF. PubMed.

TrendsMitochondria: gatekeepers of response to chemotherapy (Review).
Kristopher A. Sarosiek, Triona Ni Chonghaile, Anthony Letai.
Trends in Cell Biology, 23 September 2013. PDF. PubMed.

sciencePretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Triona Ni Chonghaile & Kristopher A. Sarosiek (co-first author), Thanh-Trang Vo, Jeremy Ryan, Anu Tammareddi, Victoria Del Gazio Moore, Jing Deng, Kenneth C. Anderson, Paul Richardson, Yu-Tzu Tai, Constantine S. Mitsiades, Ursula A. Matulonis, Ronny Drapkin, Richard Stone, Daniel J. DeAngelo, David J. McConkey, Stephen E. Sallan, Lewis Silverman, Michelle S. Hirsch, Daniel Ruben Carrasco, Anthony Letai.
Science, 25 November 2011. PDF. PubMed.

HGAL, a germinal center specific protein, regulates cell motility by modulation of the RhoA signaling pathway.
Xiaoyu Jiang, Xiaoqing Lu, George Mcnamara, Xiaofei Liu, Elena Cubedo, Kristopher A. Sarosiek, David M. Helfman, Izidore S. Lossos.
Blood, 2010 Sep 15. PubMed.
pnasEfficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.
Kristopher A. Sarosiek, Lucas Cavallin, Shruti Bhatt, Ngoc Toomey, Yasodha Natkunam, Wilfredo Blasini, Juan Ramos, Enrique Mesri, Izidore Lossos.
Proceedings of the National Academy of Sciences USA, 2010 Jul 20. PDF. PubMed.

bloodNovel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.
Kristopher A. Sarosiek, Raquel Malumbres, Hovav Nechushtan, Andrew J. Gentles, Eli Avisar, and Izidore S. Lossos.
Blood, 21 January 2010. PDF. PubMed.

bjhInterleukin-4 distinctively modifies responses of germinal center-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy.
Kristopher A. Sarosiek, Hovav Nechushtan, Xiaoqing Lu, Joseph D. Rosenblatt, Izidore S Lossos.
British Journal of Haematology., November 2009. PDF. PubMed.
Differentiation-stage-specific expression of microRNAs in B-lymphocytes and diffuse large B-cell lymphomas.
Raquel Malumbres, Kristopher A. Sarosiek, Elena Cubedo, Jose W Ruiz, Xiaoyu Jiang, Randy D Gascoyne, Robert Tibshirani, and Izidore S Lossos.
Blood, 16 April 2009. PubMed.
PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
Xiaoqing Lu, Raquel Malumbres, Benjamin Shields, Xiaoyu Jiang, Kristopher A. Sarosiek, Yasodha Natkunam, Tony Tiganis, and Izidore S. Lossos.
Blood, 15 November 2008. PubMed.
T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6.
Lu, Xiaoqing, Chen, Jun, Sasmono, R. Tedjo, Hsi, Eric D., Sarosiek, Kristopher A., Tiganis, Tony, Lossos, Izidore S.
Molecular and Cellular Biology. 2007. PubMed.