Publications

View our published work below or visit Google Scholar.

  • Giorgio Gaglia, Rumana Rashid, Clarence Yapp, Gaurav Joshi, Carmen G. Li, Susan L. Lindquist, Kristopher Sarosiek, Luke Whitesell, Peter K. Sorger & Sandro Santagata.
    HSF1 phase transition mediates stress adaptation and cell fate decisions.
    Nature Cell Biology, 2020 Feb 03. Pubmed.
  • Laura Rubio, Georgios Pyrgiotakis, Juan Beltran-Huarac, Yipei Zhang, Gaurav Joshi, Glen Deloid, Anastasia Spyrogianni, Kristopher Sarosiek, Dhimiter Bello, Philip Demokritou.
    Safer-by-design Flame-Sprayed Silicon Dioxide Nanoparticles: The Role of Silanol Content on ROS Generation, Surface Activity and Cytotoxicity.
    Particle and Fibre Toxicology, 2019 Oct 29. Pubmed.
  • Stover EH, Baco MB, Cohen O, Li YY, Christie EL, Bagul M, Goodale A, Lee Y, Pantel S, Rees MG, Wei G, Adam Presser, Gelbard MK, Zhang W, Zervantonakis IK, Bhola PD, Ryan J, Guerriero JL, Montero J, Liang FJ, Cherniack AD, Piccioni F, Matulonis UA, Bowtell DDL, Kristopher Sarosiek, Letai A, Garraway LA, Johannessen CM, Meyerson M.
    Pooled genomic screens identify anti-apoptotic genes as targetable mediators of chemotherapy resistance in ovarian cancer.
    Molecular Cancer Research, 2019 Aug 28. Pubmed.
  • Chen Lossos, Yunpeng Liu, Kellie E. Kolb, Amanda L. Christie, Alexandria Van Scoyk, Sanjay M. Prakadan, Kay Shigemori, Kristen E. Stevenson, Sara Morrow, Olivia D. Plana, Cameron Fraser, Kristen L. Jones, Huiyun Liu, Christian P. Pallasch, Rebecca Modiste, Quang-De Nguyen, Jeffrey W. Craig, Elizabeth A. Morgan, Francisco Vega, Jon C. Aster, Kristopher A. Sarosiek, Alex K. Shalek, Michael T. Hemann and David M. Weinstock
    Mechanisms of Lymphoma Clearance Induced by High-Dose Alkylating Agents.
    Cancer Discovery, 2019 April 30. Pubmed.
  • Cameron Fraser, Adam Presser, Vaishali Sanchorawala, Shayna Sarosiek, Kristopher A. Sarosiek.
    Clonal plasma cells in AL amyloidosis are dependent on pro survival BCL-2 family proteins and sensitive to BH3 mimetics (Preprint).
    BioRxiv, February 6 2019. PDF. BioRxiv.
  • Rumani Singh, Anthony Letai, Kristopher A. Sarosiek.
    Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins (Review) (Featured on cover).
    Nature Reviews Molecular Cell Biology, 2019 Jan 17. PDF. Pubmed.
  • Cameron Fraser, Jeremy Ryan, Kristopher A. Sarosiek.
    BH3 Profiling: A Functional Assay to Measure Apoptotic Priming and Dependencies (Protocol).
    Methods in Molecular Biology, January 2019;1877:61-76. PDF. Pubmed.
  • Varuna Nangia, Faria M Siddiqui, Sean Caenepeel, Daria Timonina, Samantha J Bilton, Nicole Phan, Maria Gomez-Caraballo, Hannah L Archibald, Chendi Li, Cameron Fraser, Diamanda Rigas, Kristof Vajda, Lorin A Ferris, Michael Lanuti, Cameron D Wright, Kevin A Raskin, Daniel P Cahill, John H Shin, Colleen Keyes, Lecia V. Sequist, Zofia Piotrowska, Anna F. Farago, Christopher G Azzoli, Justin F. Gainor, Kristopher Sarosiek, Sean P Brown, Angela Coxon, Cyril H. Benes, Paul E. Hughes and Aaron N. Hata.
    Exploiting MCL-1 dependency with combination MEK + MCL-1 inhibitors leads to induction of apoptosis and tumor regression in KRAS mutant non-small cell lung cancer.
    Cancer Discovery, 2018 Sep 25. Pubmed.
  • Samuel K. McBrayer, Jared R. Mayers, Gabriel J. DiNatale, Diana D. Shi, Januka Khanal, Kristopher Sarosiek, Kimberly J. Briggs, Alissa K. Robbins, Benjamin A. Olenchock, Seth J. Parker, Kensuke Tateishi, Ryan E. Looper, Keith L. Ligon, Daniel P. Cahill, John M. Asara, Christian M. Metallo, Neela H. Yennawar, Matthew G. Vander Heiden, William G. Kaelin, Jr.
    Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma.
    Cell, 2018 Sep 13. Pubmed.
  • Johan Spetz, Adam Presser, Kristopher A. Sarosiek.
    T Cells and Regulated Cell Death: Kill or Be Killed (Review).
    International Review of Cell and Molecular Biology, 2018 September. PDF. Pubmed.
  • Johan Spetz, Javid Moslehi, Kristopher A. Sarosiek.
    Radiation-Induced Cardiovascular Toxicity: Mechanisms, Prevention, and Treatment (Review).
    Current Treatment Options in Cardiovascular Medicine, 2018 April (20:31). PDF. Pubmed.
  • Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony Letai & Derrick J. Rossi
    Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage.
    Nature Cell Biology, 2018 Mar 12. Pubmed.
  • Sophie de Carné Trécesson, Frédérique Souazé, Agnès Basseville, Anne-Charlotte Bernard, Jessie Pécot, Jonathan Lopez, Margaux Bessou, Kristopher A. Sarosiek, Anthony Letai, Sophie Barillé-Nion, Isabelle Valo, Olivier Coqueret, Catherine Guette, Mario Campone, Fabien Gautier & Philippe Paul Juin
    BCL-XL directly modulates RAS signalling to favour cancer cell stemness.
    Nature Communications, 2017 Oct 24;8(1):1123. Pubmed.
  • Viswanath Gunda, Kristopher A. Sarosiek, Eran Brauner, Yon Seon Kim, Salma Amin, Zhiheng Zhou, Antony Letai, Sareh Parangi
    Inhibition of MAPKinase pathway sensitizes thyroid cancer cells to ABT-737 induced apoptosis.
    Cancer Letters, 2017 Jun 1;395:1-10. Pubmed.
  • Kristopher A. Sarosiek, Cameron Fraser, Nathiya Muthalagu, Patrick D. Bhola, Weiting Chang, Samuel K. McBrayer, Adam Cantlon, Sudeshna Fisch, Gail Golomb-Mello, Jeremy M. Ryan, Jing Deng, Brian Jian, Chris Corbett, Marti Goldenberg, Joseph R. Madsen, Ronglih Liao, Dominic Walsh, John Sedivy, Daniel J. Murphy, Daniel Ruben Carrasco, Shenandoah Robinson, Javid Moslehi, Anthony G. Letai.
    Developmental regulation of mitochondrial apoptosis by c-Myc governs age- and tissue-specific sensitivity to cancer therapeutics.
    Cancer Cell, 2017 Jan 9: 31(1):142-156. PDF. Supplemental Data. Pubmed.
  • Shawn F. Johnson, Cristina Cruz, Ann Katrin Greifenberg, Sofia Dust, Daniel G. Stover, David Chi, Benjamin Primack, Shiliang Cao, Andrea J. Bernhardy, Rhiannon Coulson, Jean-Bernard Lazaro, Bose Kochupurakkal, Heather Sun, Christine Unitt, Lisa A. Moreau, Kristopher A. Sarosiek, Maurizio Scaltriti, Dejan Juric, Jose´ Baselga, Andrea L. Richardson, Scott J. Rodig, Alan D. D’Andrea, Judith Balmana, Neil Johnson, Matthias Geyer, Violeta Serra, Elgene Lim, and Geoffrey I. Shapiro.
    CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer.
    Cell Reports, 2016 Nov 22: 17(9):2367-2381. Pubmed.
  • Shruti Bhatt, Kristopher Sarosiek, Izidore Lossos.
    Interleukin 21 – its potential role in the therapy of B-cell lymphomas (Review).
    Leukemia & Lymphoma, 2016 Jul 13:1-13. Pubmed.
  • Jan A. Burger, Dan A. Landau, Amaro Taylor-Weiner, Ivana Bozic, Huidan Zhang, Kristopher A. Sarosiek, Lili Wang, Chip Stewart, Jean Fan, Julia Hoellenriegel, Mariela Sivina, Adrian M. Dubuc, Cameron Fraser, Yulong Han, Shuqiang Li, Kenneth J. Livak, Lihua Zou, Youzhong Wan, Sergej Konoplev, Carrie Sougnez, Lynne V. Abruzzo, Scott L. Carter, Michael J. Keating, Matthew S. Davids, William G. Wierda, Kristian Cibulskis, Thorsten Zenz, Lillian Werner, Paola Dal Cin, Peter Kharchencko, Donna Neuberg, Hagop Kantarjian, Eric Lander, Stacey Gabriel, Susan O’Brien, Anthony Letai, David A. Weitz, Martin A. Nowak, Gad Getz, Catherine J. Wu.
    Clonal evolution in patients with chronic lymphocytic leukemia developing resistance to BTK inhibition.
    Nature Communications, 2016 May 20;7:11589. Pubmed.
  • FebsKristopher Sarosiek, Anthony Letai.
    Directly targeting the mitochondrial pathway of apoptosis for cancer therapy: recent success, current challenges and future promise (Review) (Featured on cover).
    FEBS Journal, 2016 Mar 21. PDF. Pubmed.
  • Janic Le Pen, Maillet Laurent, Kristopher A. Sarosiek, Céline Vuillier, Fabien Gautier, Sylvie Montessuit, Jean Claude Martinou, Anthony Letai, Frédérique Braun, Philippe P. Juin.
    Constitutive p53 heightens mitochondrial apoptotic priming and favors cell death induction by BH3 mimetic inhibitors of BCL-xL.
    Cell Death and Disease, 4 Feb 2016. Pubmed.
  • Shruti Bhatt, Julie Matthews, Salma Parvin, Kristopher A. Sarosiek, Dekuang Zhao, Xiaoyu Jiang, Elif Isik, Anthony Letai, Izidore S. Lossos.
    Direct and immune-mediated cytotoxicity of interleukin-21 contributes to antitumor effects in mantle cell lymphoma.
    Blood, 24 Sep 2015. Pubmed.
  • Joan Montero, Kristopher A. Sarosiek, Joseph D. DeAngelo, Ophélia Maertens, Jeremy Ryan, Dalia Ercan, Huiying Piao, Neil S. Horowitz, Ross S. Berkowitz, Ursula Matulonis, Pasi A. Jänne, Philip C. Amrein, Karen Cichowski , Ronny Drapkin, Anthony Letai.
    Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.
    Cell, 26 Feb 2015, 6;160(5):977-89. Pubmed.
  • Peter S. Winter, Kristopher A. Sarosiek, Kevin H. Lin, Manja Meggendorfer, Susanne Schnittger, Anthony G. Letai, and Kris C. Wood.
    Ras effector pathways drive resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
    Science Signaling, 23 Dec 2014. Pubmed.
  • Aaron N. Hata, Alan Yeo, Anthony C. Faber, Eugene Lifshits, Zhao Chen, Katherine A. Cheng, Zandra Walton, Kristopher A. Sarosiek, Anthony Letai, Rebecca S. Heist, Mari Mino-Kenudson, Kwok-Kin Wong and Jeffrey A. Engelman.
    Failure to Induce Apoptosis via BCL-2 Family Proteins Underlies Lack of Efficacy of Combined MEK and PI3K Inhibitors for KRAS-Mutant Lung Cancers.
    Cancer Research, 2014, June 1. Pubmed.
  • Neil Johnson, Shawn F. Johnson, Wei Yao, Yu-Chen Li, Young-Eun Choi, Andrea J. Bernhardy, Yifan Wang, Marzia Capelletti, Kristopher A. Sarosiek, Lisa A. Moreau, et al.
    Stabilization of mutant BRCA1 protein confers PARP inhibitor and platinum resistance.
    Proceedings of the National Academy of Sciences USA, 2013, Oct 1. Pubmed.
  • molcellKristopher A. Sarosiek , Xiaoke Chi, John A. Bachman, Joshua J. Sims, Joan Montero, Luv Patel, Annabelle Flanagan, David W. Andrews, Peter Sorger, Anthony Letai.
    BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response.
    Molecular Cell, 26 September 2013. PDF. Pubmed.
  • TrendsKristopher A. Sarosiek, Triona Ni Chonghaile, Anthony Letai.
    Mitochondria: gatekeepers of response to chemotherapy (Review).
    Trends in Cell Biology, 23 September 2013. PDF. Pubmed.
  • scienceTriona Ni Chonghaile & Kristopher A. Sarosiek (co-first author), Thanh-Trang Vo, Jeremy Ryan, Anu Tammareddi, Victoria Del Gazio Moore, Jing Deng, Kenneth C. Anderson, Paul Richardson, Yu-Tzu Tai, Constantine S. Mitsiades, Ursula A. Matulonis, Ronny Drapkin, Richard Stone, Daniel J. DeAngelo, David J. McConkey, Stephen E. Sallan, Lewis Silverman, Michelle S. Hirsch, Daniel Ruben Carrasco, Anthony Letai.
    Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
    Science, 25 November 2011. PDF. Pubmed.
  • Xiaoyu Jiang, Xiaoqing Lu, George Mcnamara, Xiaofei Liu, Elena Cubedo, Kristopher A. Sarosiek, David M. Helfman, Izidore S. Lossos.
    HGAL, a germinal center specific protein, regulates cell motility by modulation of the RhoA signaling pathway.
    Blood, 2010 Sep 15. Pubmed.
  • pnasKristopher A. Sarosiek, Lucas Cavallin, Shruti Bhatt, Ngoc Toomey, Yasodha Natkunam, Wilfredo Blasini, Juan Ramos, Enrique Mesri, Izidore Lossos.
    Efficacy of bortezomib in a direct xenograft model of primary effusion lymphoma.
    Proceedings of the National Academy of Sciences USA, 2010 Jul 20. PDF. Pubmed.
  • bloodKristopher A. Sarosiek, Raquel Malumbres, Hovav Nechushtan, Andrew J. Gentles, Eli Avisar, and Izidore S. Lossos.
    Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas.
    Blood, 21 January 2010. PDF. Pubmed.
  • bjhKristopher A. Sarosiek, Hovav Nechushtan, Xiaoqing Lu, Joseph D. Rosenblatt, Izidore S Lossos.
    Interleukin-4 distinctively modifies responses of germinal center-like and activated B-cell-like diffuse large B-cell lymphomas to immuno-chemotherapy.
    British Journal of Haematology., November 2009. PDF. Pubmed.
  • Raquel Malumbres, Kristopher A. Sarosiek, Elena Cubedo, Jose W Ruiz, Xiaoyu Jiang, Randy D Gascoyne, Robert Tibshirani, and Izidore S Lossos.
    Differentiation-stage-specific expression of microRNAs in B-lymphocytes and diffuse large B-cell lymphomas.
    Blood, 16 April 2009. Pubmed.
  • Xiaoqing Lu, Raquel Malumbres, Benjamin Shields, Xiaoyu Jiang, Kristopher A. Sarosiek, Yasodha Natkunam, Tony Tiganis, and Izidore S. Lossos.
    PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling.
    Blood, 15 November 2008. Pubmed.
  • Lu, Xiaoqing, Chen, Jun, Sasmono, R. Tedjo, Hsi, Eric D., Sarosiek, Kristopher A., Tiganis, Tony, Lossos, Izidore S.
    T-Cell Protein Tyrosine Phosphatase, Distinctively Expressed in Activated-B-Cell-Like Diffuse Large B-Cell Lymphomas, Is the Nuclear Phosphatase of STAT6.
    Molecular and Cellular Biology. 2007. Pubmed.