A cross-platform catalogue of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines
Gene expression in lymphoblastoid cell lines was characterized in two independent datasets, one sample of 405 siblings using Affymetrix HG U133 Plus 2.0 chips and the other sample of 550 siblings using Illumina Human6V1 array. Among these individuals, 928 were also genotyped at >300,000 SNPs using the Illumina HumanHap300 arrays, with additional genotypes for 8 million SNPs in the 1000 Genomes Project filled in using imputation. This website provides genome-wide significant cis and trans association analysis results (FDR<5% account for all SNP-probe pairs).
To search significant eQTLs (FDR<5%) by gene or position and browse on UCSC genome browser
MRCA (Affymetrix Expression) search by gene/probeset names
MRCA (Affymetrix Expression) search by positions
MRCE (Illumina Expression) search by gene/probeset names
MRCE (Illumina Expression) search by positions
Flat files download:
MRCA eQTL database (Affymetrix expression array, n=405)
MRCE eQTL database (Illumina expression array,n=550)
Meta-analysis results (_A indicates results from Affymetrix expression dataset and _I indicates results from Illumina expression dataset)
Citation:
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Liming Liang, Nilesh Morar, Anna L Dixon, G Mark Lathrop, Goncalo R Abecasis, Miriam F Moffatt, William O C Cookson (2012) A cross-platform catalogue of 14,177 expression quantitative trait loci derived from lymphoblastoid cell lines.Genome Research doi:10.1101/gr.142521.112) |