Recent Selection of Publications

Silva-García, C.G., Láscarez-Lagunas, L.I., Papsdorf, K. et al. The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegansNat Aging 3, 1358–1371 (2023). https://doi.org/10.1038/s43587-023-00517-8

Smith HJ, Lanjuin A, Sharma A, Prabhakar A, Nowak E, Stine PG, et al. (2023) Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in Celegans. PLoS Genet 19(9): e1010938. https://doi.org/10.1371/journal.pgen.1010938

Inouye KE, Prentice KJ, Lee A, Wang ZB, Dominguez-Gonzalez C, Chen MX, Riveros JK, Burak MF, Lee GY, Hotamışlıgil GS. Endothelial-derived FABP4 constitutes the majority of basal circulating hormone and regulates lipolysis-driven insulin secretion. JCI Insight. 2023 Jul 24;8(14):e164642. doi: 10.1172/jci.insight.164642. PMID: 37279064; PMCID: PMC10443803.

Prentice KJ, Lee A, Cedillo P, Inouye KE, Ertunc ME, Riveros JK, Lee GY, Hotamisligil GS. Sympathetic tone dictates the impact of lipolysis on FABP4 secretion. J Lipid Res. 2023 Jun;64(6):100386. doi: 10.1016/j.jlr.2023.100386. Epub 2023 May 10. PMID: 37172691; PMCID: PMC10248869.

Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN, Shirihai OS. Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA. EMBO J. 2023 Jun 1;42(11):e111901. doi: 10.15252/embj.2022111901. Epub 2023 Mar 14. PMID: 36917141; PMCID: PMC10233380.

Hosios AM, Wilkinson ME, McNamara MC, Kalafut KC, Torrence ME, Asara JM, Manning BD. mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022 Dec;4(12):1792-1811. doi: 10.1038/s42255-022-00706-6. Epub 2022 Dec 19. PMID: 36536136; PMCID: PMC9799240.

McNamara MC, Hosios AM, Torrence ME, Zhao T, Fraser C, Wilkinson M, Kwiatkowski DJ, Henske EP, Wu CL, Sarosiek KA, Valvezan AJ, Manning BD. Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex. iScience. 2022 Oct 28;25(11):105458. doi: 10.1016/j.isci.2022.105458. PMID: 36388985; PMCID: PMC9663903.

Schrötter S, Yuskaitis CJ, MacArthur MR, Mitchell SJ, Hosios AM, Osipovich M, Torrence ME, Mitchell JR, Hoxhaj G, Sahin M, Manning BD. The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth. Cell Rep. 2022 May 17;39(7):110824. doi: 10.1016/j.celrep.2022.110824. PMID: 35584673.

Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O’Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G. Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nat Commun. 2022 May 16;13(1):2698. doi: 10.1038/s41467-022-30362-z. PMID: 35577785; PMCID: PMC9110385.

Parlakgül G, Arruda AP, Pang S, Cagampan E, Min N, Güney E, Lee GY, Inouye K, Hess HF, Xu CS, Hotamışlıgil GS. Regulation of liver subcellular architecture controls metabolic homeostasis. Nature. 2022 Mar;603(7902):736-742. doi: 10.1038/s41586-022-04488-5. Epub 2022 Mar 9. PMID: 35264794; PMCID: PMC9014868.

Liou YH, Personnaz J, Jacobi D, Knudsen NH, Chalom MM, Starost KA, Nnah IC, Lee CH. Hepatic Fis1 regulates mitochondrial integrated stress response and improves metabolic homeostasis. JCI Insight. 2022 Feb 22;7(4):e150041. doi: 10.1172/jci.insight.150041. PMID: 35015731; PMCID: PMC8876406.

Prentice KJ, Saksi J, Robertson LT, Lee GY, Inouye KE, Eguchi K, Lee A, Cakici O, Otterbeck E, Cedillo P, Achenbach P, Ziegler AG, Calay ES, Engin F, Hotamisligil GS. A hormone complex of FABP4 and nucleoside kinases regulates islet function. Nature. 2021 Dec;600(7890):720-726. doi: 10.1038/s41586-021-04137-3. Epub 2021 Dec 8. PMID: 34880500; PMCID: PMC8983123.

Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 Nov 23;37(8):110037. doi: 10.1016/j.celrep.2021.110037. PMID: 34818536; PMCID: PMC8720303.

Byles V, Cormerais Y, Kalafut K, Barrera V, Hughes Hallett JE, Sui SH, Asara JM, Adams CM, Hoxhaj G, Ben-Sahra I, Manning BD. Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Mol Metab. 2021 Nov;53:101309. doi: 10.1016/j.molmet.2021.101309. Epub 2021 Jul 23. PMID: 34303878; PMCID: PMC8368025.

Torrence ME, MacArthur MR, Hosios AM, Valvezan AJ, Asara JM, Mitchell JR, Manning BD. The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 2021 Mar 1;10:e63326. doi: 10.7554/eLife.63326. PMID: 33646118; PMCID: PMC7997658.

Ristow M, Lee CH, De Bock K, Gladyshev VN, Hotamisligil GS, Manning BD. James R. Mitchell (1971-2020). Cell Metab. 2021 Mar 2;33(3):458-461. doi: 10.1016/j.cmet.2021.02.009. PMID: 33657387.

Hui S, Cowan AJ, Zeng X, Yang L, TeSlaa T, Li X, Bartman C, Zhang Z, Jang C, Wang L, Lu W, Rojas J, Baur J, Rabinowitz JD. Quantitative Fluxomics of Circulating Metabolites. Cell Metab. 2020 Oct 6;32(4):676-688.e4. doi: 10.1016/j.cmet.2020.07.013. Epub 2020 Aug 12. PMID: 32791100; PMCID: PMC7544659.

Burkewitz K, Feng G, Dutta S, Kelley CA, Steinbaugh M, Cram EJ, Mair WB. Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis. Cell Rep. 2020 Sep 8;32(10):108125. doi: 10.1016/j.celrep.2020.108125. PMID: 32905769; PMCID: PMC8030272.

Knudsen NH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Starost KA, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, Narkar VA, Ortlund EA, Kim JH, Paton CM, Cooper JA, Lee CH. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science. 2020 May 1;368(6490):eaat3987. doi: 10.1126/science.aat3987. Epub 2020 Apr 30. PMID: 32355002; PMCID: PMC7549736.

Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN. Glucose-dependent partitioning of arginine to the urea cycle protects β-cells from inflammation. Nat Metab. 2020 May;2(5):432-446. doi: 10.1038/s42255-020-0199-4. Epub 2020 May 11. PMID: 32694660; PMCID: PMC7568475.

Zhang Y, Lanjuin A, Chowdhury SR, Mistry M, Silva-García CG, Weir HJ, Lee CL, Escoubas CC, Tabakovic E, Mair WB. Neuronal TORC1 modulates longevity via AMPK and cell nonautonomous regulation of mitochondrial dynamics in C. elegans. Elife. 2019 Aug 14;8:e49158. doi: 10.7554/eLife.49158. PMID: 31411562; PMCID: PMC6713509.

Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP. Mol Cell. 2019 Jul 25;75(2):357-371.e7. doi: 10.1016/j.molcel.2019.05.019. Epub 2019 Jun 18. PMID: 31227231; PMCID: PMC6744259.