Molecular Metabolism Faculty

Barbara Burleigh
Professor of Molecular Metabolism
Professor of Immunology and Infectious Diseases

The Burleigh lab focuses on lipid metabolism at the host-pathogen interface and its role in Chagas disease cardiomyopathy as well as understanding the impact of metabolic microenvironment in treatment failure of Chagas disease.

Robert V. Farese, Jr.
Professor of Molecular Metabolism
Chair, Department of Molecular Metabolism

The Farese/Walther lab studies lipid and energy metabolism in cells. We seek to understand how lipids macromolecules are generated, stored, and metabolized, and how lipid processes function in membrane biology and cell physiology. We focus on disorders such as obesity, type 2 diabetes, and neurobiological diseases such as frontotemporal dementia (FTD).

Wendy Garrett
Professor of Molecular Metabolism
Professor of Immunology and Infectious Diseases

My lab studies the interplay between the gastrointestinal immune system and the gut microbiome. We explore how the gut microbiota influence both innate (myeloid cell) and adaptive (T cell) immunity, and how these processes contribute to immune homeostasis and disease.

Gökhan S. Hotamışlıgil
James Stevens Simmons Professor of Genetics and Metabolism
Director, Sabri Ülker Center for Nutrient, Genetic and Metabolic Research

The Hotamışlıgil Lab at the Sabri Ülker Center studies innate adaptive pathways involved in metabolic health and diseases such as obesity, diabetes, and cardiovascular disease. For the past 25 years, our lab has made important contributions to the burgeoning field of “immunometabolism”, studying the interactions between metabolic and immune responses as critical drivers of numerous chronic diseases. In the last decade, we have approached immunometabolism in these two paths: organelle homeostasis and lipid metabolism. Using biochemical, genetic, and physiological studies, we aim to find novel pathways and preventive, therapeutic solutions to today’s greatest threats to global human health.

Chih-Hao Lee
Professor of Molecular Metabolism

The main research interest of the lab is to understand bioenergetic controls of physiological processes that impact metabolic health. We use a variety of tools in molecular/cell biology, biochemistry and metabolomics as well as mouse models of obesity and related metabolic diseases to explore these questions.

Sheng (Tony) Hui
Assistant Professor of Molecular Metabolism

My laboratory studies mammalian energy metabolism, including how dietary intake and energy expenditure synergize physiologically, and how disruptions of this balance cause disease.

Quan Lu
Associate Professor of Molecular Metabolism
Associate Professor of Environmental Genetics and Pathophysiology

My research is focused on the mechanistic understanding of how the environment contributes to human health and disease. We combine the power for functional genetics and genomics, mechanistic studies, and human epidemiology to tackle important public health problems.

William Mair
Associate Professor of Molecular Metabolism

Our lab studies the basic biology of the aging process, driven by the central question: Why are we more likely to get chronic diseases when we are old than when we are young? What goes wrong in cells and tissues to increase overall disease risk, and is this decline inevitable, or can we reverse it to bring healthy years to the elderly?

Brendan D. Manning
Professor of Molecular Metabolism

The Manning lab investigates the regulation and function of the PI3K-mTOR signaling network under physiological and pathological settings.  Our lab employs hypothesis-driven approaches utilizing genetics, biochemistry, cell biology, and animal models combined with unbiased systems-level tools like genomics, proteomics, metabolomics, and bioinformatics. Our premise is that delineating the complex circuitry of signaling networks within cells will shed light on how best to directly stimulate or inhibit these pathways in order to prevent or treat human diseases like cancer and Type II diabetes.

Frank Sacks
Professor of Molecular Metabolism
Professor of Cardiovascular Disease Prevention

Dr. Sacks’s research program combines laboratory research on human lipoprotein metabolism with clinical trials in nutrition and cardiovascular disease. His lab investigates the acute and chronic effects of diet on the function of lipoproteins in humans. He also studies the biochemical epidemiology of lipoprotein particle types. Finally, his clinical trials group runs multi-center clinical trials that investigate the effects of various dietary regimens on cardiovascular disease, dementia, insulin resistance, and weight loss.

Tobias Walther
Professor of Molecular Metabolism
Executive Director, Harvard T.H. Chan School of Public Health Analytics Center
Director, Center on Causes and Prevention of Cardiovascular Disease

The Farese/Walther lab studies lipid and energy metabolism in cells. We seek to understand how lipid macromolecules are generated, stored, and metabolized, and how lipid processes function in membrane biology and cell physiology. We focus on disorders such as obesity, type 2 diabetes, and neurobiological diseases such as frontotemporal dementia (FTD).

Adjunct Faculty

James R. Mitchell
Adjunct Professor of Molecular Metabolism

My lab studies the mechanisms underlying beneficial effects on lifespan, healthspan and stress resistance imparted by dietary restriction using rodent models. We are also exploring practical ways to apply dietary restriction to address clinical problems including metabolic syndrome and surgical complications.