With poignant lessons learned from the COVID-19 pandemic fresh in our minds, faculty member Laura Kubzansky, PhD, corresponding author on a Comment published in Nature Human Behavior, makes a strong case for why prosociality (defined as positive other-regarding behaviors and beliefs) should be more deeply explored—with a sense of urgency—as part of an ‘asset-based’ approach to address the rising rates of hopelessness, despair, and poor mental health in the U.S.