Thursday, November 14, 2013
Joseph B. Martin Conference Center
3rd Floor Rotunda
8-8:30am Registration and Breakfast
8:30-8:35 Opening Remarks
SESSION I – CHROMATIN REGULATION IN DISEASES
8:35-9:15
Stephen Baylin – KEYNOTE SPEAKER
Johns Hopkins University
Dissecting Mechanisms Underlying and Translational Implications of the Cancer Epigenome
9:15-9:20 Questions and Discussion
9:20-9:45
Zhiping Weng
University of Massachusetts Medical School
Epigenomics of Human Prefrontal Cortex Neurons
9:45-9:50 Questions and Discussion
9:50-10:00
Eugenio Marco, Dana-Farber Cancer Institute | Abstract Winner Platform Talk
Hierarchical Annotation of Chromatin States in Stem Cells
10:00-10:05 Questions and Discussion
10:05-10:30 BREAK
10:30-10:55
William Noble
University of Washington
Virulence genes play an organizational role in the dynamic genome architecture of P. falciparum
10:55-11:00 Questions and Discussion
11:00-11:25
Leonid Mirny
Massachusetts Institute of Technology
Genome in 3D
11:25-11:30 Questions and Discussion
11:30-11:55
Or Gozani
Stanford University
Breaking Bad: Lysine Methyl Signaling in Chromatin and Disease Regulation
11:55-12:00 Questions and Discussion
12:00-1:15 LUNCH
SESSION II – EPIGENETICS OF GENETIC VARIANCE IN DISEASE
1:15-1:40
Matthew Freedman
Dana-Farber Cancer Institute
Charting the AR Cistrome in Human Prostate Tissue
1:40-1:45 Questions and Discussion
1:45-2:10
Peter Scacheri
Case Western Reserve University
Multiple Enhancer Variants in Common Disease
2:10-2:15 Questions and Discussion
2:15-2:40
Manolis Kellis
Massachusetts Institute of Technology
Regulatory and Systems Genomics of Complex Traits
2:40-2:45 Questions and Discussion
2:45-3:10 BREAK
3:10-3:35
Jason Lieb
Princeton University
Mutations in the H3K36 methyltransferase SETD2 link chromatin defects with aberrant RNA processing in human kidney cancer
3:35-3:40 Questions and Discussion
3:40-3:50
Maya Kasowski, Stanford University | Abstract Winner Platform Talk
Extensive Variation in Chromatin States Across Humans
3:50-3:55 Questions and Discussion
3:55-4:40
PANEL DISCUSSION
Functional implications of epigenetic changes – how to identify epigenetic drivers
Panelists:
Andrea Baccarelli, Harvard School of Public Health | Co-Leader
Guocheng Yuan, Harvard School of Public Health/DFCI | Co-Leader
Wei Li, Baylor College of Medicine
Jason Lieb, University of North Carolina at Chapel Hill
Mathieu Lupien, University of Toronto
Chris Mason, Cornell University
Peter Park, Harvard Medical School
Kimberly Siegmund, University of Southern California
4:40-4:45 Questions and Discussion
4:45-6:30 Poster Session and Reception (2nd floor lounge)
FRIDAY, NOVEMBER 15, 2013
Joseph B. Martin Conference Center
3rd Floor Rotunda
8-8:30am Breakfast
SESSION III – DNA METHYLATION, SOMATIC MUTATIONS, AND DISEASES
8:30-9:10
Rafael Irizarry – KEYNOTE SPEAKER
Harvard School of Public Health & Dana-Farber Cancer Institute
Parsing variability and detecting signal in disease epigenetic studies
9:10-9:15 Questions and Discussion
9:15-9:40
Ari Melnick
Weill Cornell Medical College
Epigenetic Mechanisms and Epigenetic Targeted Therapy for B-cell lymphomas
9:40-9:45 Questions and Discussion
9:45-9:55
Yaping Liu, USC Epigenome Center | Abstract Winner Platform Talk
Mapping nucleosome organization in cancer cells using NOMe-seq
9:55-10:00 Questions and Discussion
10:00-10:25 Break
10:25-10:50
Andrew Smith
University of Southern California
Examining the variation of intergenic hypomethylation in lung cancers
10:50-10:55 Questions and Discussion
10:55-11:20
Ben Berman
University of Southern California
Deciphering combinatorial epigenomic patterns using NOMe-seq
11:20-11:25 Questions and Discussion
11:25-11:50
Martin Hirst
University of British Columbia
Epigenetic Determinants of Mammary Gland Development
11:50-11:55 Questions and Discussion
11:55-12:00 Closing Remarks and Award Presentation
