We have been actively investigating the global trend of early-onset cancers (generally meaning adult cancers diagnosed before age 50) in many different organs.
In our analyses published in a review (Ugai T et al. Nat Rev Clin Oncol 2022; https://www.nature.com/articles/s41571-022-00672-8), early-onset cancers in the breast, colorectum, endometrium, esophagus, extrahepatic bile duct, gallbladder, head & neck, kidney, liver, bone marrow (multiple myeloma), pancreas, and stomach has exhibited rising incidence in multiple countries. Among those 12 cancer types, 8 relate to the digestive system, potentially implicating the important pathogenic role of diets and intestinal microbiome.
