Key References on MPE

Below is a list of 22 references.  A shorter list of 10 essential references on MPE will appear at SERplaylists (SER = Society for Epidemiologic Research).


1.  Introduction of molecular pathological epidemiology (MPE)


Ogino S, Nishihara R, VanderWeele TJ, Wang M, Nishi A, Lochhead P, Qian ZR, Zhang X, Wu K, Nan H, Yoshida K, Milner DA, Chan AT, Field AE, Camargo CA, Williams MA, Giovannucci EL. The role of molecular pathological epidemiology in the study of neoplastic and non-neoplastic diseases in the era of precision medicine.  Epidemiology 2016;27:602-611.  (This paper introduced the disease continuum theory, and relevance and applicability of the MPE paradigm to all diseases.  In addition, this paper introduced the integrative fields of “pharmaco-MPE” and “immuno-MPE”.)


Ogino S, Chan AT, Fuchs CS, Giovannucci E.  Gut 2011

(this paper also explains the GWAS-MPE approach)



Field AE, Camargo CA Jr, Ogino S.  JAMA 2013


Nishihara R, VanderWeele TJ, Shibuya K, Mittleman MA, Wang M, Field AE, Giovannucci E, Lochhead P, Ogino S.  Eur J Epidemiol 2015

(This paper shows how simply the MPE approach can solve epidemiologic paradoxes.)


Ogino S, Stampfer M.  J Natl Cancer Inst 2010

(The term “molecular pathological epidemiology” appeared for the first time.  MPE appeared as a unique field.)


2.  The unique disease principle, the fundamental theory behind MPE, which goes along with the Precision Medicine Initiative of NIH.


Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, Giovannucci E.  Mod Pathol 2013


Please also read this paper on the Unique Tumor Principle, which led to the Unique Disease Principle.

Ogino S, Fuchs CS, Giovannucci E.  Expert Rev Mol Diagn 2012


3.  Papers (selected) on methods to investigate etiologic heterogeneity


Wang M, Spiegelman D, Kuchiba A, Lochhead P, Kim S, Chan AT, Poole EM, Tamimi R, Tworoger SS, Giovannucci E, Rosner B, Ogino S. Statistical methods for studying disease subtype heterogeneity. Stat Med 2016;35:782-800.

(We developed and compiled methods of examining subtype heterogeneity in various settings of MPE research.)


Wang M, Kuchiba A, Ogino S.  Am J Epidemiol 2015


4.  Integrative education in pathology and epidemiology for 21st century public health


Ogino S, King EE, Beck AH, Sherman ME, Milner DA, Giovannucci E.



5.  Meeting and symposium proceedings related to MPE, including the International MPE Meeting Series


Ogino S, Campbell PT, Nishihara R, Phipps AI, Beck AH, Sherman ME, Chan AT, Troester MA, Bass AJ, Fitzgerald KC, Irizarry RA, Kelsey KT, Nan H, Peters U, Poole EM, Qian ZR, Tamimi RM, Tchetgen Tchetgen EJ, Tworoger SS, Zhang X, Giovannucci EL, van den Brandt PA, Rosner BA, Wang M, Chatterjee N, Begg CB.  Cancer Causes Cont 2015


Campbell PT, Rebbeck TR, Nishihara R, Beck AH, Begg CB, Bogdanov AA, Cao Y, Coleman HG, Freeman GJ, Heng YJ, Huttenhower C, Irizarry RA, Kip NS, Michor F, Nevo D, Peters U, Phipps AI, Poole EM, Qian ZR, Quackenbush J, Robins H, Rogan PK, Slattery ML, Smith-Warner SA, Song M, VanderWeele TJ, Xia D, Zabor EC, Zhang X, Wang M, Ogino S. Proceedings of the Third International Molecular Pathological Epidemiology (MPE) Meeting.  Cancer Causes Cont (in press).


7.  The etiologic field effect model, which emerged as MPE is integrated into the conventional field effect model.


Lochhead P, Chan AT, Nishihara R, Fuchs CS, Beck AH, Giovannucci E, Ogino S.


8.  The integrative lifecourse-MPE model (lifecourse epidemiology – MPE)


Nishi A, Kawachi I, Koenen KC, Wu K, Nishihara R, Ogino S. (full text freely available at Pubmed Central in December 2015)