Key References on MPE

Below is a list of key references in molecular pathological epidemiology (MPE).


Introduction of MPE

Ogino S, et al.  Annu Rev Pathol 2019.

Ogino S, et al.  Epidemiology 2016;27:602-611.

Ogino S, et al.  Gut 2011 (GWAS-MPE approach)


Integration of microbiology, microbiomics, immunology, and immunomics into MPE

Inamura K, et al. Gut (online).

Ogino S, et al. Gut 2018.


Lifecourse MPE research (for early-onset cancer)

Ugai T, et al. Nat Rev Clin Oncol 2022 (early-onset cancers in many organs)

Akimoto N, et al. Nat Rev Clin Oncol 2021 (early-onset colorectal cancer)

Nishi A, et al. Am J Prev Med 2015.


Epidemiological paradox solving

Nishihara R, VanderWeele TJ, Shibuya K, Mittleman MA, Wang M, Field AE, Giovannucci E, Lochhead P, Ogino S.  Eur J Epidemiol 2015.


The unique disease principle, the fundamental theory behind MPE

Ogino S, et al.  Mod Pathol 2013

Ogino S, et al.  Expert Rev Mol Diagn 2012


The etiologic field effect model

Lochhead P, Chan AT, Nishihara R, Fuchs CS, Beck AH, Giovannucci E, Ogino S.


Papers (selected) on methods to investigate etiologic heterogeneity

Wang M, Spiegelman D, Kuchiba A, Lochhead P, Kim S, Chan AT, Poole EM, Tamimi R, Tworoger SS, Giovannucci E, Rosner B, Ogino S. Statistical methods for studying disease subtype heterogeneity. Stat Med 2016;35:782-800.

Wang M, Kuchiba A, Ogino S.  Am J Epidemiol 2015


Meeting and symposium proceedings related to MPE, including the International MPE Meeting Series

Ogino S, Campbell PT, Nishihara R, Phipps AI, Beck AH, Sherman ME, Chan AT, Troester MA, Bass AJ, Fitzgerald KC, Irizarry RA, Kelsey KT, Nan H, Peters U, Poole EM, Qian ZR, Tamimi RM, Tchetgen Tchetgen EJ, Tworoger SS, Zhang X, Giovannucci EL, van den Brandt PA, Rosner BA, Wang M, Chatterjee N, Begg CB.  Cancer Causes Cont 2015


Campbell PT, Rebbeck TR, Nishihara R, Beck AH, Begg CB, Bogdanov AA, Cao Y, Coleman HG, Freeman GJ, Heng YJ, Huttenhower C, Irizarry RA, Kip NS, Michor F, Nevo D, Peters U, Phipps AI, Poole EM, Qian ZR, Quackenbush J, Robins H, Rogan PK, Slattery ML, Smith-Warner SA, Song M, VanderWeele TJ, Xia D, Zabor EC, Zhang X, Wang M, Ogino S. Proceedings of the Third International Molecular Pathological Epidemiology (MPE) Meeting.  Cancer Causes Cont (in press).