Novel Integrative Paradigms and Concepts

Since 2010, I have created a number of new integrative concepts and paradigms, which are listed below.

Molecular pathological epidemiology (MPE).  MPE was first described in S Ogino, M Stampfer. J Natl Cancer Inst 2010.

http://jnci.oxfordjournals.org/content/102/6/365.full

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841039/

http://en.wikipedia.org/wiki/Molecular_pathological_epidemiology

 

Immunology-MPE (including immuno-genomics)

Immunology-MPE (molecular pathological epidemiology) is an integrative field of immunology and MPE for prevention and treatment of many diseases.  ​We utilize our MPE analytical strategy to investigate the combined role of exposures and immunity in carcinogenesis and tumor progression.  The concept of immuno-MPE has been described in Ogino S et al. Epidemiology 2016 (https://www.ncbi.nlm.nih.gov/pubmed/26928707); Hamada T et al. J Gastroenterol (online https://www.ncbi.nlm.nih.gov/pubmed/27738762).  The latter also describe the concept of “microbial MPE (molecular pathological epidemiology)“.  Please see some highlights from our immuno-MPE and microbial MPE research!

 

M Song et al. Gut 2016, “Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status”).  gut.bmj.com/content/early/2015/01/13/gutjnl-2014-308852.abstract

M Song et al. (JAMA Oncology 2016) have shown that marine omega-3 polyunsaturated fatty acid intake is associated with lower risk of colorectal cancer that contains abundant FOXP3+ Treg cells.  www.ncbi.nlm.nih.gov/pubmed/27148825

Y Cao et al. (Gastroenterology 2016) have shown that regular aspirin use is associated with lower risk of colorectal cancer with low-level tumor-infiltrating lymphocytes (TILs).  www.ncbi.nlm.nih.gov/pubmed/27475305

M Giannakis et al. (Cell Reports 2016) have shown a positive correlation between neoantigen load (derived from whole exome sequencing data) and T lymphocytic infiltrates.  www.ncbi.nlm.nih.gov/pubmed/27149842

Y Masugi et al. (Gut 2016 online) have shown an inverse association between tumor CD274 (PD-L1) expression and FOXP3+ Treg cell density in colorectal cancer, implying mutually alternative mechanisms of immunosuppression.  This is one of the largest study on CD274 (PD-L1) expression in colorectal carcinoma.  www.ncbi.nlm.nih.gov/pubmed/27196573

R Mehta et al. (JAMA Oncology online) have shown the association of prudent diets with a lower risk of colorectal cancer subtype with PCR-detectable Fusobacterium nucleatum. https://www.ncbi.nlm.nih.gov/pubmed/28125762

 

Pharmaco-MPE

See https://www.hsph.harvard.edu/shuji-ogino/pharmaco-mpe/

 

The GWAS-MPE approach.  GWAS-MPE, which stands for genome-wide association study-MPE, was first described in S Ogino et al. Gut 2011 (published online in 2010).

http://gut.bmj.com/content/60/3/397.abstract

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040598/

The colorectal continuum model.  This model was first described in M Yamauchi et al. Gut 2012.

http://gut.bmj.com/content/early/2012/04/04/gutjnl-2012-302014.extract (the short concept paper which introduced the term “colorectal continuum”.)

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3345045/ (full text in Pubmed Central.)

http://gut.bmj.com/content/61/6/847.long (this is the original article by M Yamauchi et al. Gut 2012, which tested the colorectal continuum hypothesis.)

The Unique Tumor Principle (UTP).  This principle was first described in S Ogino et al. Expert Rev Mol Diagn 2012, and S Ogino, E Giovannucci. Int J Epidemiol 2012.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3492839/ (the concept paper which introduced the unique tumor principle)

http://ije.oxfordjournals.org/content/41/4/1072.full (this editorial first appeared in the literature with the unique tumour principle in its title)

The Unique Disease Principle (UDP).  This principle was first described in S Ogino et al. Mod Pathol 2013.

http://www.nature.com/modpathol/journal/v26/n4/full/modpathol2012214a.html

The Etiologic Field Effect model.  This model was first described in P Lochhead et al. Mod Pathol 2015 (published online in 2014).

http://www.nature.com/modpathol/journal/v28/n1/full/modpathol201481a.html

The lifecourse MPE model.  This model was first described in A Nishi et al. Am J Prev Med 2015 (published online in 2014).

http://www.ajpmonline.org/article/S0749-3797(14)00568-6/abstract

 

The integrative field of Social MPE.   This was first described in A Nishi et al. Expert Rev Mol Diagn 2016 (published online in 2015).

http://www.tandfonline.com/doi/full/10.1586/14737159.2016.1115346