Microbiology-MPE (Microbiomic MPE)

Much beyond traditional paradigms of immunology and microbiology, we have been developing scientific fields, including “immunology-MPE (molecular pathological epidemiology)” and “microbiology-MPE (molecular pathological epidemiology)”.  Microbiology and immunology are closely related.  We integrate diverse fields including immunology, microbiology, molecular pathology, and epidemiology, to create new ways of research.
We investigate complex inter-relationships between diet, lifestyle, environmental factors, microorganisms (microbiota), host immunity (including immune response to tumor), molecular pathology, and tumor development and progression in large human populations.

We have published this concept paper “Integration of microbiology, molecular pathology, and epidemiology: a new paradigm to explore the pathogenesis of microbiome‐driven neoplasm” in J Pathol (onlinelibrary.wiley.com/doi/abs/10.1002/path.5236).

Recent highlights include a study on diet and incidence of colorectal carcinoma subtypes classified by tissue Fusobacterium nucleatum (Mehta R et al. JAMA Oncology 2017).  Our study showed the association of prudent diets with a lower risk of colorectal cancer subtype with PCR-detectable Fusobacterium nucleatum.  www.ncbi.nlm.nih.gov/pubmed/28125762