We have been examining interactions of diet (nutrition), medication use, lifestyle variables, and tumor molecular, microbial, and immune characteristics in relation to incidence and mortality of colorectal carcinoma. Therefore, this “nutritional MPE” has close links to “pharmaco-MPE”, “microbial MPE” and “immuno-MPE”.
Some notable publications:
L Li et al. (Gastroenterology, online) have shown that inflammatory diets are associated with high risk of colorectal cancer that contains lower levels of intratumor periglandular (stromal) lymphocytes. This study also used the approach of “immuno-MPE“.
M Song et al. (JAMA Oncology 2016) have shown that marine omega-3 polyunsaturated fatty acid intake is associated with lower risk of colorectal cancer that contains abundant FOXP3+ Treg cells. This study also used the approach of “immuno-MPE”.
Dietary fiber, Prudent diet pattern
Mehta R et al. JAMA Oncol 2017. (Fusobacterium nucleatum in tumor tissue)
Song M et al. Gut 2016. (lymphocytic reaction to tumor)
One-carbon nutrients (folate, other vitamin B, alcohol)
Schernhammer E et al. Gastroenterology 2008. (TP53 expression by immunohistochemistry)
Schernhammer E et al. Cancer Epidemiol Biomarkers Prev 2008. (KRAS mutation, MSI status)
Schernhammer E et al. Gut 2010. (LINE-1 methylation)
Schernhammer E et al. PLoS ONE 2011. (CIMP, BRAF mutation)
Nishihara R et al. Am J Clin Nutr 2014. (IGF2 DMR0 methylation)
Lochhead P et al. Am J Clin Nutr 2015. (interactions with molecular markers in survival analysis)
Dietary glycemic and insulin scores
Keum N et al. Int J Cancer 2017. (interaction with tumor molecular features in survival analysis)