Dr. Linda Harrison, PhD Research Scientist, Harvard T.H. Chan School of Public Health, Department of Biostatistics An Evaluation of Confidence Intervals for a Cumulative Proportion to Enable Decisions at Interim Reviews of Single Arm Clinical Trials Abstract: Clinical trials often include interim analyses of the proportion of participants experiencing an event by a fixed time … Continue reading "HIV Working Group Seminar"
Jinghui Zhang Endowed Chair in Bioinformatics St. Jude Children’s Research Hospital Therapy-related clonal evolution driven by mutations and structural alterations of pediatric cancers and long-term survivors
Sajia Darwish Doctoral Student, Department of Biostatistics, Harvard University Theory-driven statistical estimation of racism-related themes in the medical literature Abstract: The scientific study of racism as a root cause of health inequities has been hampered by the policies and practices of medical journals. Monitoring the discourse around racism and health inequities in scientific publications is … Continue reading "Quantitative Issues in Cancer Research Working Group Seminar"
Eric Van Buren Postdoctoral Fellow in Biostatistics & Statistical Genetics Harvard T.H. Chan School of Public Health cellSTAAR: Incorporating single-cell-sequencing-based functional data to boost power in rare variant association testing of non-coding regions Whole genome sequencing studies have identified hundreds of millions of rare variants, the majority of which are in non-coding regions and of … Continue reading "PQG Seminar"
Carmen Rodriguez Cabrera Doctoral Student, Department of Biostatistics, Harvard T.H. Chan School of Public Health Abstract: Personalized medicine has become very popular because it recognizes that individuals may respond differently to the same treatment due to differences in their underlying biology. With the emergence of large amounts of data coming from electronic health records linked with … Continue reading "Quantitative Issues in Cancer Research Working Seminar"
Keith Barnatchez PhD Student, Harvard T.H. Chan School of Public Health, Department of Biostatistics "Estimating Causal Effects with Error-Prone Exposures Using Control Variates" Abstract: Exposure measurement error poses a common challenge to performing causal inference in observational studies. Despite the growing body of work at the intersection of causal inference and measurement error, there remains a … Continue reading "HIV Working Group Seminar"
Shamil Sunyaev Professor of Biomedical Informatics, Harvard Medical School Professor of Medicine, Brigham and Women’s Hospital The puzzling variation of complex traits
Rong Ma Assistant Professor, Department of Biostatistics, Harvard T.H. Chan School of Public Health A Spectral Approach to Assessing and Combining Multiple Data Embeddings Abstract: Dimension reduction is an indispensable part of modern data science, and many algorithms have been developed. However, different algorithms have their own strengths and weaknesses, making it important to evaluate their … Continue reading "Quantitative Issues in Cancer Research Working Group Seminar"
Kaia Mattioli Postdoctoral Research Fellow Brigham and Women’s Hospital Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms Transcription factors (TFs) control gene expression by interacting with DNA and cofactors to regulate transcription. Human TF genes produce multiple protein isoforms with altered DNA binding domains, effector domains, and other protein regions. The … Continue reading "PQG Working Group"
Daniel Schwartz Postdoctoral Research Fellow, Department of Biostatistics, Harvard T.H. Chan School of Public Health Treatment Effect Estimation in Multisite Trials with Endogenous Design: Old Estimators, New Results Abstract: In large-scale multisite randomized trials, key design features such as the sample size at each site often arise from an unpredictable social process. As a result, … Continue reading "Quantitative Issues in Cancer Research Working Group Seminar"
