Ron Do Associate Professor of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai Advances in Mendelian Randomization: Robust Causal Inference and Identification of Risk Factors for Coronary … Continue reading "PQG Seminar"
Wenhan Lu Analytic and Translational Genetics Unit HMS, MGH, Broad Institute Quantifying the extent of pleiotropy using rare variant association data in 394,841 human exomes Genome-wide association studies (GWAS) and … Continue reading "PQG Working Group"
Karl Tayeb PhD Candidate University of Chicago Integrating functional annotations to estimate variant effect sizes from GWAS The distribution of causal variants-- both their distribution throughout the genome, as well as the magnitude of their effects-- is a fundamental quantity that underpins many key questions in genetics. Knowledge of this distribution can be used … Continue reading "PQG Working Group"
Yu Chen Analytic and Translational Genetics Unit HMS, MGH, Broad Institute Enhanced Interpretation of Schizophrenia GWAS of Diverse Ancestry with Brain Regulatory Architecture of Matched Population Previous genetic studies of … Continue reading "PQG Working Group"
Molly Schumer Assistant Professor in Biology Stanford University The evolution of reproductive isolation: insights from swordtail fish Hybridization, or the exchange of genes between different species, is much more common than previously recognized. In the past decade, the genome sequencing revolution has allowed us to peer into the evolutionary histories of myriad species. This has … Continue reading "PQG Seminar"
Saori Sakaue Postdoctoral Research Fellow HMS A scalable approach to use single-cell multimodal data to fine-map disease causal variants and links them to target genes After 20 years of genome-wide association study (GWAS), rarely have we identified causal variants or genes. Translating GWAS loci into causal variants and genes requires accurate cell-type-specific enhancer-gene maps from … Continue reading "PQG Working Group"
Joshua Popp PhD Candidate Johns Hopkins University Investigating dynamic genetic regulation in diverse cell types and differentiation trajectories Large-scale efforts to identify genetic variants associated with nearby gene expression levels (cis expression quantitative trait loci, or cis-eQTLs) have focused primarily on healthy adult tissues, potentially overlooking effects specific to transient cell states such as those … Continue reading "PQG Working Group"
Longzhi Tan Assistant Professor of Neurobiology Stanford University Probing the single-cell 3D genome architectural basis of neurodevelopment and aging in vivo How do cells in our nervous system develop highly specialized functions despite having (approximately) the same genome? An emerging mechanism is 3D genome architecture: the folding of our 2-meter-long genome into each 10-micron cell nucleus. … Continue reading "PQG Seminar"
Martin Zhang Postdoctoral Research Fellow Harvard T.H. Chan School of Public Health Quantifying and partitioning SNP effect correlation across UK Biobank traits While traditional heritability estimation methods such as … Continue reading "PQG Working Group"
Ying Wang Research Fellow HMS, MGH, Broad Institute Challenges and opportunities for developing more generalizable polygenic risk scores Polygenic risk scores (PRS) estimate an individual’s genetic likelihood of complex … Continue reading "PQG Working Group"
