Marouen Ben Guebila Research Fellow Department of Biostatistics Multiclass network inference reveals distinct parameter regions in gene regulatory space Gene expression is controlled by complex regulatory processes that allow … Continue reading "PQG Working Group"
Haky Im Assistant Professor of Medicine and Human Genetics University of Chicago Polygenic Transcriptome Risk Scores Translate Polygenic Evidence Across Ancestries and Species Polygenic risk scores (PRS) are promising to … Continue reading "PQG Seminar"
Ayshwarya Subramanian Computational Biologist Broad Institute Comparative transcriptomics of mouse and human kidneys to study disease altered cell states Mouse models are a tool for studying the mechanisms underlying complex … Continue reading "PQG Working Group"
Alex Marson Professor, Director of the Gladstone-UCSF Institute of Genomic Immunology UCSF Decoding and Reprogramming T Cell Circuitry with CRISPR The goal of the Marson lab is to understand genetic … Continue reading "PQG Seminar"
Haoyu Zhang Postdoctoral Fellow Department of Biostatistics, Harvard T.H. Chan School of Public Health Methods for risk prediction using integrative multi-ethnic genetic and genomic datasets Polygenic risk scores (PRS) are … Continue reading "PQG Working Group"
Priya Moorjani Assistant Professor, Dept. of Molecular and Cell Biology UC Berkeley An evolutionary perspective on the human mutation rate Germline mutations are the source of all heritable variation. Understanding … Continue reading "PQG Seminar"
Martin Jinye Zhang Postdoctoral Researcher, Department of EpidemiologyHarvard T.H. Chan School of Public Health Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data Gene expression at the individual cell-level resolution, as quantified by single-cell RNA-sequencing (scRNA-seq), can provide unique insights into the pathology and cellular origin of diseases and complex traits. Here, we … Continue reading "PQG Working Group"
Melissa Gymrek Assistant Professor, Medicine UC San Diego Polymorphic short tandem repeats make widespread contributions to complex traits Recent studies have made substantial progress in identifying genetic variants associated with disease and molecular phenotypes in humans. However, these studies have primarily focused on single nucleotide polymorphisms (SNPs), ignoring more complex variants that have been shown … Continue reading "PQG Seminar"
Olivier Delaneau Professor, Systems and Population Genetics Group, Department of Computational Biology University of Lausanne Efficient imputation of low-coverage whole genome sequencing data Low-coverage whole-genome sequencing (LC-WGS) followed by imputation has been proposed as a cost-effective genotyping approach for disease and population genetics studies. In this seminar, we describe GLIMPSE, an efficient method for phasing … Continue reading "PQG Seminar"
Oliver Stegle Professor of Computational Genomics and Systems Genetics EMBL Heidelberg From genotype to phenotype with single-cell resolution The study of genetic effects on gene expression using bulk-RNA sequencing has … Continue reading "PQG Seminar"
