Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion

In a paper published in JCI Insight, titled, “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”, a team of researchers from the Hotamışlıgil … Continue reading “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”

Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans

In a recent paper published in PLoS Genetics, Dr. Mair and his team led by Hannah Smith, demonstrated that selectively inhibiting mechanistic target of rapamycin complex 1 (mTORC1) in neurons … Continue reading “Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans”

Mitochondrial morphology controls fatty acid utilization by changing CPT1sensitivity to malonyl-CoA

In a paper published in the EMBO Journal in February, the Danial (Molecular Metabolism/ Dana Farber Cancer Institute) and Shirihai (UCLA) labs reported that fatty acid utilization is selectively coupled … Continue reading “Mitochondrial morphology controls fatty acid utilization by changing CPT1sensitivity to malonyl-CoA”