Cancer cachexia, a debilitating syndrome characterized by systemic wasting in cancer patients, has long confounded researchers seeking to identify its underlying mechanisms. A recent study published in EMBO Reports sheds … Continue reading “IL-6 promotes tumor growth through immune evasion but is dispensable for cachexia”
In a recent publication in The Journal of Clinical Investigation, Abigael Cheruiyot, PhD, of the Schaffer Lab, led the research that uncovered a translational regulatory circuit within pancreatic beta cells that plays a vital … Continue reading “Sustained hyperglycemia specifically targets translation of mRNAs for insulin secretion”
There was a new printer installed in the SPH2-first floor kitchen last week. For those of you who use this device, I have included below a few instructions for you to … Continue reading “New Printer in SPH2-104 Kitchen: Instructions”
Hi MET Colleagues, It was nice to see many of you at our invited speaker seminar yesterday. We have an outstanding line up of speakers that come in once per … Continue reading “Dr. Manning Note Regarding MET Seminars”
Dear friends and colleagues, The Departments of Immunology and Infectious Diseases and Molecular Metabolism announce the appointment of Professor Barbara Burleigh as Professor Emeritus in the faculty of the Harvard … Continue reading “Announcing the appointment of Barbara Burleigh as Professor Emeritus”
Aging is a natural process, yet it can be accelerated or delayed by internal and external factors. In particular, CREB-regulated transcriptional coactivators (CRTCs) have emerged as novel modulators of aging … Continue reading “The CRTC-1 transcriptional domain is required for COMPASS complex-mediated longevity in C. elegans”
In a paper recently published in the Journal of Lipid Research, Kacey Prentice and a group of scientists from Hotamışlıgil Lab at the Sabri Ülker Center demonstrated that secretion of fatty acid … Continue reading “Sympathetic tone dictates the impact of lipolysis on FABP4 secretion”
In a paper published in JCI Insight, titled, “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”, a team of researchers from the Hotamışlıgil … Continue reading “Endothelial FABP4 constitutes the majority of basal circulating hormone levels and regulates lipolysis-driven insulin secretion”
In a recent paper published in PLoS Genetics, Dr. Mair and his team led by Hannah Smith, demonstrated that selectively inhibiting mechanistic target of rapamycin complex 1 (mTORC1) in neurons … Continue reading “Neuronal mTORC1 inhibition promotes longevity without suppressing anabolic growth and reproduction in C. elegans”
In a paper published in the Journal of Lipid Research, Kacey Prentice, PhD, and a group of scientists from the Hotamışlıgil Lab at the Sabri Ülker Center demonstrated that secretion … Continue reading “Sympathetic tone dictates the impact of lipolysis on FABP4 secretion”
In a paper published in the EMBO Journal in February, the Danial (Molecular Metabolism/ Dana Farber Cancer Institute) and Shirihai (UCLA) labs reported that fatty acid utilization is selectively coupled … Continue reading “Mitochondrial morphology controls fatty acid utilization by changing CPT1sensitivity to malonyl-CoA”
We are pleased to announce that Dr. Marie Sabatier has received an Institut Servier fellowship to provide support for her training in the Ubellacker Lab. Institut Servier offers grants to promote the opportunity … Continue reading “Dr. Marie Sabatier has received an Institut Servier fellowship”
In a recent paper published in Nature Metabolism mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species, Department of Molecular Metabolism postdoctoral fellow Aaron Hosios and other colleagues in … Continue reading “mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species”
In a paper published in iScience, Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex, from the Laboratory of Professor Brendan Manning, MollyMcNamara Goodrich … Continue reading “Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex”
Dear MET Colleagues, I am excited to welcome you all to Thompson Island for the 2022 Department of Molecular Metabolism Retreat. We are long overdue for a department-wide day of … Continue reading “MET Department Retreat to Thompson Island”
Armen H. Tashjian, Jr., M.D. Dr. Tashjian, Professor of Toxicology, Emeritus, in the Department of Genetics and Complex Diseases at the Harvard T.H. Chan School of Public Health, led the … Continue reading “2024 Tashjian Award Program”
In a paper published in Cell Reports, Schrötter and colleagues describe a mouse knockout model of TBC1D7, a core component of the complex disrupted in a genetic tumor and neurological … Continue reading “The non-essential TSC complex component TBC1D7 restricts tissue mTORC1 signaling and brain and neuron growth”
-Written by Noel Jackson | NSF GRFP 2021 Fellow | BBS PhD Candidate – Mair Lab | Department of Molecular Metabolism Two hundred and fifty years ago an obscure man … Continue reading “Understanding of the macromolecular building blocks, with Dr. Marie Maynard Daly”
Dear Colleagues, I am writing to share that EH&S and HUHS are revising the Harvard University On-Campus Activity Guidance in response to the surge of COVID-19 cases in our community … Continue reading “January 12, 2022 – Covid Update From Katrina Soriano”
Sponsored by the Department of Molecular Metabolism Harvard T.H. Chan School of Public Health May 3 @ 12 PM EST The Inaugural Professor Marianne Wessling-Resnick Distinguished Lecturer Peter Tontonoz, MD, PhD … Continue reading “Professor Marianne Wessling-Resnick Distinguished Lecture”
The mission of the Biddinger Lab is to improve the lives of patients with diabetes. We leverage bioinformatic, biochemical, genetic, and physiological studies to enable new diagnostics and treatments. We … Continue reading “Post-Doctoral Fellowship in Diabetes at Boston Children’s Hospital”
