MET Newsletter Spring 2023 | Department of Molecular Metabolism | Harvard T.H. Chan School of Public Health

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IL-6 promote tumor growth through immune evasion but is dispensable for cachexia

New study in EMBO Reports challenges conventional wisdom on cancer cachexia, finding that IL-6 and LIF are not as crucial as once thought.
Sustained hyperglycemia targets translation of mRNAs for insulin secretion

Research uncovered a translational regulatory circuit within pancreatic beta cells that plays a vital role in insulin secretion.
The CRTC-1 transcriptional domain is required for COMPASS complex-mediated ...

Mair Lab identifies that CRTC-1 in aging suppresses longevity when AMPK is activated while promoting longevity through epigenetic regulation.
Neuronal mTORC1 inhibition promotes longevity...

This work challenges previously held theories that anabolic trade-offs are required for mTORC1 longevity and highlights a critical role ...
Sympathetic tone dictates the impact of lipolysis on FABP4 secretion

Recent work by MET researchers demonstrates that secretion of FABP4 from adipocytes can be induced through sympathetic signaling
Unlocking cellular secrets to better treat diseases

Sophie Lockwood, PhD ’23, uncovered a complex biological mechanism that could potentially help in drug development

IL-6 promote tumor growth through immune evasion but is dispensable for cachexia