Biostatistics Journal Club with Andrea Foulkes – 5/1

Biostatistics Journal Club with Andrea Foulkes flyer

Biostatistics Journal Club: Defining Long COVID Without a Gold Standa

Moderate to severe post-acute sequelae of SARS-CoV-2 infection (PASC), also called long COVID, is estimated to impact as many as 10% of SARS-CoV-2 infected individuals, representing a chronic condition with a substantial global public health burden. An expansive literature has identified over 200 long-term and persistent symptoms associated with a history of SARS-CoV-2 infection; yet there remains to be a clear consensus on a syndrome definition. Such a definition is a critical first step in future studies of risk and resiliency factors, mechanisms of disease, and interventions for both treatment and prevention.

Register here.

Andrea Foulkes, ScD, of Massachusetts General Hospital, recently applied a strategy for defining PASC based on a least absolute shrinkage operator model which leverages information on history of SARS-CoV-2 infection. This talk will present a formalization and evaluation of this approach with theoretical derivations and simulation studies, including a demonstration that it appropriately a) selects symptoms that associate with PASC and b) results in a score that has high discriminatory power for detecting PASC. An application to data on 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) in the RECOVER (Researching COVID to Enhance Recovery) Adult Cohort is presented to illustrate the findings.

Suggested Reading:

Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection