Events Calendar

Donald Jackson, Ph.D. Group Head of Precision Oncology Bioinformatics, Sanofi "Precision Oncology: Advancing Drug Discovery with Genomic Data" ABSTRACT: Continuing advances in genomics and bioinformatics are transforming drug discovery. At Sanofi Precision Oncology, we use genomics and bioinformatics to identify new targets, understand drug mechanism of action, select indications, identify biomarkers, and assess drug response. … Continue reading "Quantitative Issues in Cancer Research Working Seminar"

Malika Aid-Boudries, Ph.D. Instructor in Medicine, Center for Virology and Vaccine Research/Barouch Laboratory "Pre-vaccination Biomarkers of Vaccines Response Efficacy in SIV Infected NHP Model" ABSTRACT: In a previously published work by our group, using four independent cohorts of rhesus macaques vaccinated with different vaccine regimens then challenged with SIVmac251, we showed that animals required different … Continue reading "HIV Working Group"

Sahand Hormoz, Ph.D. Assistant Professor of Systems Biology, Harvard Medical School "What Can Single Cell Lineage Trees Tell Us About Blood Cancers?" ABSTRACT: I will talk about our recent efforts to determine when cancer first occurs and the dynamics of its expansion in individual patients with a type of blood cancer called myeloproliferative neoplasm. We … Continue reading "Quantitative Issues in Cancer Research Working Seminar"

Andy Shi Doctoral Student, Department of Biostatistics, Harvard University "Multiple Phenotype - Multiple Genotype Testing with Multidimensional Scan Statistics" ABSTRACT: The increasing popularity of large-scale genetic compendiums has driven a recent interest in (1) testing sets of genotypes against a single phenotype and (2) testing sets of phenotypes against a single genotype. Incorporating the information … Continue reading "Quantitative Issues in Cancer Research Working Seminar"

Lara Maleyeff Doctoral Student, Department of Biostatistics, Harvard University "Estimating and Testing Treatment Effect Heterogeneity in Stepped Wedge Cluster Randomized Trials with Binary Outcomes" ABSTRACT: Stepped wedge cluster randomized trials, which involve unidirectional crossover to treatment, are a vital tool in HIV research. Since clusters are followed over time with varying points of treatment initiation, … Continue reading "HIV Working Group"

Jane Liang Doctoral Student, Department of Biostatistics, Harvard University "Aggregating Across Genes and Cancers in Mendelian Risk Prediction Modeling" ABSTRACT: Identifying individuals whose risk of cancer is increased as a result of carrying heritable pathogenic mutations is important for clinical management and research. Using principles of Mendelian genetics, Bayesian probability theory, and mutation-specific knowledge, Mendelian … Continue reading "Quantitative Issues in Cancer Research Working Seminar"